Differential patterns of psychomotor functioning in unmedicated melancholic and nonmelancholic depressed patients

Pier, M.P.B.I.; Hulstijn, Wouter; Sabbe, Bernard

doi:10.1016/j.jpsychires.2003.11.008

Cited by 73 publications

(50 citation statements)

References 38 publications

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“…On the other hand, although all included patients in our analysis continued with exactly the same benzodiazepine concentrations in the AD-free period before stimulation, the use of benzodiazepines in our sample might have been a confounding variable. (Pier et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…As psychomotor retardation is one of the key features of this type of depression (Sobin and Sackeim, 1997;Gold and Chrousos, 2002;Pier et al, 2004), this group should be in particular suitable to evaluate psychomotor changes in rTMS paradigms. Because a higher level of psychomotor retardation has been associated with reduced metabolic activities in the left dorsolateral prefrontal cortex (DLPFC) -suggesting an important role of this cortical area on psychomotor functioning (Schrijvers et al, 2008) -we targeted this prefrontal cortical area under MRI guidance.…”

Section: Introductionmentioning

confidence: 99%

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HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression

Baeken¹,

Raedt²,

Santermans³

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression

Baeken¹,

Raedt²,

Santermans³

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…This psychomotor change symptom cluster has an important clinical, diagnostic, pathophysiological, and therapeutic significance in the clinical and scientific approach of Major Depressive Disorder (MDD) (4)(5)(6)(7)(8). Psychomotor retardation (PR) has repeatedly been denoted as an important marker of the melancholia subtype of depression (5,(9)(10)(11), and as a predictor for treatment response to several types of antidepressant treatment (5). Since psychomotor functioning is the only factor of depression that does not correlate with severity of depression and since it is not predictive for clinical outcome, it is thought to be a dimension defining a separate type (3), though not exclusively the melancholic subtype of depression.…”

Section: Introductionmentioning

confidence: 99%

Cognitive and psychomotor effects of three months of escitalopram treatment in elderly patients with major depressive disorder

Beheydt

Schrijvers

Docx

et al. 2015

Journal of Affective Disorders

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Please be advised that this information was generated on 2018-05-09 and may be subject to change. Background: Psychomotor retardation (PR) is one of the core features in depression according to DSM V (1), but also aging in itself causes cognitive and psychomotor slowing. This is the first study investigating PR in relation to cognitive functioning and to the concomitant effect of depression and aging in a geriatric population ruling out contending effects of psychotropic medication. PSYCHIATRY ORIGINAL RESEARCH ARTICLE Methods:A group of 28 non-demented depressed elderly is compared to a matched control group of 20 healthy elderly. All participants underwent a test battery containing clinical depression measures, cognitive measures of processing speed, executive function and memory, clinical ratings of PR, and objective computerized fine motor skill-tests. Statistical analysis consisted of a General Linear Method multivariate analysis of variance to compare the clinical, cognitive, and psychomotor outcomes of the two groups. Results:Patients performed worse on all clinical, cognitive, and PR measures. Both groups showed an effect of cognitive load on fine motor function but the influence was significantly larger for patients than for healthy elderly except for the initiation time.Limitations: Due to the restrictive inclusion criteria, only a relatively limited sample size could be obtained. Conclusion:With a medication free sample, an additive effect of depression and aging on cognition and PR in geriatric patients was found. As this effect was independent of demand of effort (by varying the cognitive load), it was apparently not a motivational slowing effect of depression.

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“…This computerized task is an objective and reliable method to assess fine motor activity, and is generally considered to be a rater-independent and more objective measurement method than the more subjective rating scales [9]. The Fitts’ task has been widely used in the research into psychomotor symptoms in MDD [17,18,19]. This fine motor task requires a precise sensorimotor programming, initiation and execution of the muscle commands [17,18,19].…”

Section: Introductionmentioning

confidence: 99%

“…The Fitts’ task has been widely used in the research into psychomotor symptoms in MDD [17,18,19]. This fine motor task requires a precise sensorimotor programming, initiation and execution of the muscle commands [17,18,19]. One HF-rTMS session with parameters comparable to rTMS treatment for depression has been reported to affect this psychomotor functioning in healthy subjects [20].…”

Section: Introductionmentioning

confidence: 99%

The Impact of High-Frequency Repetitive Transcranial Magnetic Stimulation on Fine Motor Functions in Medication-Resistant Major Depression

Schrijvers

Baeken²,

Raedt

et al. 2012

Neuropsychobiology

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Objectives: Although high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been reported to improve mood symptoms in major depressive disorder (MDD), research on its impact on psychomotor symptoms is scarce. This study assessed the psychomotor effects of 1 and 10 sessions, respectively, of HF-rTMS over the left DLPFC. Methods: Ten HF-rTMS sessions were applied in 21 medication-free MDD patients over a 2-week period. At the beginning, one placebo (sham)-controlled rTMS session was also applied in a cross-over, single-blind design. Psychomotor variables were digitally recorded during completion of a Fitts’ task, at baseline, after the first and second real/sham session and at the end point. Results: The total 10-session treatment period resulted in a decrease of depression severity. One HF-rTMS session resulted in improvements on the Fitts’ task, without a difference between active and sham stimulation, however. No further improvements occurred from session 2 to session 10. Conclusions: No evidence was provided to link the observed psychomotor improvements to HF-rTMS stimulation, as a practice effect could have impacted the significant psychomotor outcomes.

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Differential patterns of psychomotor functioning in unmedicated melancholic and nonmelancholic depressed patients

Cited by 73 publications

References 38 publications

HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression

HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression

Cognitive and psychomotor effects of three months of escitalopram treatment in elderly patients with major depressive disorder

The Impact of High-Frequency Repetitive Transcranial Magnetic Stimulation on Fine Motor Functions in Medication-Resistant Major Depression

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