Differential Ontogenesis of Three DOI-Induced Behaviors in Mice

Darmani, Nissar A.; Shaddy, James H.; Gerdes, C

doi:10.1016/s0031-9384(96)00323-x

Cited by 50 publications

(41 citation statements)

References 29 publications

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“…Epidemiological data indicate that human adolescents are more involved in reckless behaviors such as hazardous driving, unprotected sex, and substance use, compared to adults (Spear, 2000), and low levels of harm avoidance and anxiety are associated with these behaviors (Arnett, 1992;Maggs, Almeida, & Galambos, 1995). Adolescent rats and mice, at approximately PD 28-42, are often hyperactive and exhibit greater exploration in novel environments than younger or older animals (Darmani, Shaddy, & Gerdes, 1996;Spear, Shalaby, & Brick, 1980). These behavioral tendencies may be associated with developmental alterations in anxiety.…”

Section: Discussionmentioning

confidence: 99%

Effects of early weaning on anxiety and prefrontal cortical and hippocampal myelination in male and female wistar rats

Kodama

Kikusui

Takeuchi

et al. 2008

Developmental Psychobiology

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We investigated developmental changes in myelin formation in the prefrontal cortex and the hippocampus, and behavioral effects of early weaning in Wistar rats. Early-weaned rats showed decreased numbers of open-arm entries in an elevated plus-maze in both sexes at 4 weeks old; this effect persisted in males, but ceased in females after this age. Expression of myelin basic protein (MBP) showed both age-dependent increases and sex differences; 4-week-old males exhibited higher MBP levels in the hippocampus, whereas 7-week-old males showed lower MBP levels in the prefrontal cortex compared to females of the same age. There was a tendency for group differences from weaning for the 21.5-kDa isoform in the prefrontal cortex. Although these results suggest that male rats are more vulnerable than females to early-weaning effects on anxiety-related behaviors, further detailed analysis is needed to clarify the functional relationship between myelination and anxiety-related behaviors.

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Section: Discussionmentioning

confidence: 99%

Effects of early weaning on anxiety and prefrontal cortical and hippocampal myelination in male and female wistar rats

Kodama

Kikusui

Takeuchi

et al. 2008

Developmental Psychobiology

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“…And indeed, adolescents of other species also seem to seek out novel and potentially risky aspects of their environment. Adolescent mice are hyperactive in a novel environment [114], and exhibit higher levels of novelty seeking than their adult counterparts [4]. Rats in the age range from around P28-42 are often hyperactive and exhibit greater exploration in novel situations than other aged rats (e.g.…”

Section: Risk Takingmentioning

confidence: 99%

“…For instance, Darmani and colleagues [114] examined ontogeny of psychopharmacological sensitivity to the 5HT 2A agonist, (^)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) in mice and observed that DOI-induced head twitches and ear scratching increased developmentally to peak at P28 and between P22 and P35, respectively, with the incidence of both behaviors declining thereafter; DOIinduced increases in locomotor activity were only evident in mice up to 28 days of age and not thereafter. Serotonergic innervation of basal forebrain in rats also shows considerably ontogenetic change, with the number of serotonergic synapses reaching adult levels by P14 prior to dropping to levels considerably below adult levels by weaning at P21 [135]; unfortunately no ages were examined between weaning and adulthood, and hence the relevance of these changes in basal forebrain 5HT systems for adolescent neurobehavioral function are unknown.…”

Section: Serotonergic Alterations During Adolescencementioning

confidence: 99%

The adolescent brain and age-related behavioral manifestations

Spear

2000

Neuroscience & Biobehavioral Reviews

4,699

111

4,363

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To successfully negotiate the developmental transition between youth and adulthood, adolescents must maneuver this often stressful period while acquiring skills necessary for independence. Certain behavioral features, including age-related increases in social behavior and risk-taking/novelty-seeking, are common among adolescents of diverse mammalian species and may aid in this process. Reduced positive incentive values from stimuli may lead adolescents to pursue new appetitive reinforcers through drug use and other risk-taking behaviors, with their relative insensitivity to drugs supporting comparatively greater per occasion use. Pubertal increases in gonadal hormones are a hallmark of adolescence, although there is little evidence for a simple association of these hormones with behavioral change during adolescence. Prominent developmental transformations are seen in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems. Developmental changes in these stressor-sensitive regions, which are critical for attributing incentive salience to drugs and other stimuli, likely contribute to the unique characteristics of adolescence. ᭧

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“…According to some studies, by the time adolescents reach their senior year of high school, approximately 50% have used marijuana/hashish, 65% have smoked cigarettes, and 82% have tried alcohol (cited in Spear, 2000). Although animal models suggest that elevated risk taking during this age period may actually be adaptive with evolutionary antecedents (Darmani, Shaddy, & Gerdes, 1996;Galef, 1981;Gardner, 1993), for humans, risk taking carries with it a potential for long-lasting consequences, including alcohol and drug dependence, legal problems, and an escalation of a deviant lifestyle into adulthood (Lerner & Galambos, 1998;Spear, 2000). Adolescents engaged in alcohol and drug use report more delinquent activity and are more likely to have been arrested than other youths (Braithwaite, Conerly, Robillard, Stephens, & Woodring, 2003).…”

mentioning

confidence: 99%

Cognitive Markers of Adolescent Risk Taking: A Correlate of Drug Abuse in At-Risk Individuals

2005

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Behavioral traits associated with adolescent risk taking may be correlated with maturational events occurring in the brain. Adolescent brains are less developed than previously believed, particularly in prefrontal cortex, a region implicated in moderating behavior related to drug use. One indictor used to assess frontal lobe functioning is the Tower of Hanoi. The authors compared substance-involved adolescents with a control group of resilient youth on their Tower of Hanoi performance and detected significantly different error patterns across the two groups. Resilient youths made fewer moves and spent more time per move; their substance-involved counterparts made more moves and spent less time per move, a strategy that could be construed as impulsive.

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Differential Ontogenesis of Three DOI-Induced Behaviors in Mice

Cited by 50 publications

References 29 publications

Effects of early weaning on anxiety and prefrontal cortical and hippocampal myelination in male and female wistar rats

Effects of early weaning on anxiety and prefrontal cortical and hippocampal myelination in male and female wistar rats

The adolescent brain and age-related behavioral manifestations

Cognitive Markers of Adolescent Risk Taking: A Correlate of Drug Abuse in At-Risk Individuals

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