Differential of Frequency and Duration Mismatch Negativity and Theta Power Deficits in First-Episode and Chronic Schizophrenia

Xiong, Yongqian; Bo, Qijing; Wang, Changming; Tian, Qing; Liu, Yi; Wang, Chuanyue

doi:10.3389/fnbeh.2019.00037

Cited by 25 publications

(29 citation statements)

References 50 publications

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“…These MMN effects were concurrent with ketamine-induced disruptions in evoked theta power and theta phase locking and are consistent with findings linking MMN dysfunction in chronic and first episode schizophrenia primarily to an impaired theta frequency response (Todd et al, 2008; Bishop and Hardiman, 2010; Moran and Hong, 2011; Choi et al, 2013; Hermann et al, 2014; Xiong et al, 2019). It has been suggested that by diminished theta power modulation and phase resetting in response to speech stimuli, may contribute to cognitive dysfunction in schizophrenia, and may be linked to the impaired interplay between cortical pyramidal neurons and circuit SST-type GABAergic interneurons (Javitt et al, 2018).…”

Section: Discussionsupporting

confidence: 85%

NMDA Receptor Antagonist Effects on Speech-Related Mismatch Negativity and Its Underlying Oscillatory and Source Activity in Healthy Humans

et al. 2019

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Background: Previous studies in schizophrenia have consistently shown that deficits in the generation of the auditory mismatch negativity (MMN)-a pre-attentive, eventrelated potential (ERP) typically elicited by changes to simple sound features-are linked to N-methyl-D-aspartate (NMDA) receptor hypofunction. Concomitant with extensive language dysfunction in schizophrenia, patients also exhibit MMN deficits to changes in speech but their relationship to NMDA-mediated neurotransmission is not clear. Accordingly, our study aimed to investigate speech MMNs in healthy humans and their underlying electrophysiological mechanisms in response to NMDA antagonist treatment. We also evaluated the relationship between baseline MMN/electrocortical activity and emergent schizophrenia-like symptoms associated with NMDA receptor blockade. Methods: In a sample of 18 healthy volunteers, a multi-feature Finnish language paradigm incorporating changes in syllables, vowels and consonant stimuli was used to assess the acute effects of the NMDA receptor antagonist ketamine and placebo on the MMN. Further, measures of underlying neural activity, including evoked theta power, theta phase locking and source-localized current density in cortical regions of interest were assessed. Subjective symptoms were assessed with the Clinician Administered Dissociative States Scale (CADSS). Results: Participants exhibited significant ketamine-induced increases in psychosislike symptoms and depending on temporal or frontal recording region, co-occurred with reductions in MMN generation in response to syllable frequency/intensity, vowel duration, across vowel and consonant deviants. MMN attenuation was associated with decreases in evoked theta power, theta phase locking and diminished current density in auditory and inferior frontal (language-related cortical) regions. Baseline (placebo) MMN and underlying electrophysiological features associated with the processing of changes in syllable intensity correlated with the degree of psychotomimetic response to ketamine.

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Section: Discussionsupporting

confidence: 85%

NMDA Receptor Antagonist Effects on Speech-Related Mismatch Negativity and Its Underlying Oscillatory and Source Activity in Healthy Humans

et al. 2019

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“…Discrepant findings have been reported with the regard to the dMMN amplitude. In particular, some studies found a reduction of dMMN amplitude in FEP ( 66 , 151 , 188 – 191 ) and FES subjects ( 65 , 95 , 181 , 182 , 190 , 192 – 196 ) as compared to HCs, while other studies did not find any abnormality in dMMN amplitude in FEP and FES subjects ( 183 , 197 – 200 ). Furthermore, a study, involving ML to distinguish FES from HCs with dMMN measures in addition to other neuroimaging and clinical evaluations, highlighted that this EEG-index did not contribute significantly to the discriminant ML-model ( 158 ).…”

Section: Resultsmentioning

confidence: 95%

“…Abnormalities in theta activity were reported also during task performance ( 83 , 88 , 94 – 96 ). In particular, task-related abnormal theta activity was detected during a processing speed ( 94 ), an arithmetic ( 88 ) or an auditory task ( 95 ) in FES ( 88 , 95 ) and FEP subjects ( 94 ). In addition, two studies highlighted brain network dysfunctions in theta band in FES as compared to HCs, as suggested by abnormalities in neuronal information transmission during an executive functioning task ( 83 ) and a reduction of the “small-world network” index ( 96 ), a parameter assessing cerebral networks topology and the efficiency of neuronal signaling processing.…”

Section: Resultsmentioning

confidence: 99%

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

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Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have been largely reported. In the last decades, research has shifted to the identification of electrophysiological alterations in the prodromal and early phases of the disorder, focusing on the prediction of clinical and functional outcome. The identification of neuronal aberrations in subjects with a first episode of psychosis (FEP) and in those at ultra high-risk (UHR) or clinical high-risk (CHR) to develop a psychosis is crucial to implement adequate interventions, reduce the rate of transition to psychosis, as well as the risk of irreversible functioning impairment. The aim of the review is to provide an up-to-date synthesis of the electrophysiological findings in the at-risk mental state and early stages of schizophrenia.Methods: A systematic review of English articles using Pubmed, Scopus, and PsychINFO was undertaken in July 2020. Additional studies were identified by hand-search. Electrophysiological studies that included at least one group of FEP or subjects at risk to develop psychosis, compared to healthy controls (HCs), were considered. The heterogeneity of the studies prevented a quantitative synthesis.Results: Out of 319 records screened, 133 studies were included in a final qualitative synthesis. Included studies were mainly carried out using frequency analysis, microstates and event-related potentials. The most common findings included an increase in delta and gamma power, an impairment in sensory gating assessed through P50 and N100 and a reduction of Mismatch Negativity and P300 amplitude in at-risk mental state and early stages of schizophrenia. Progressive changes in some of these electrophysiological measures were associated with transition to psychosis and disease course. Heterogeneous data have been reported for indices evaluating synchrony, connectivity, and evoked-responses in different frequency bands.Conclusions: Multiple EEG-indices were altered during at-risk mental state and early stages of schizophrenia, supporting the hypothesis that cerebral network dysfunctions appear already before the onset of the disorder. Some of these alterations demonstrated association with transition to psychosis or poor functional outcome. However, heterogeneity in subjects' inclusion criteria, clinical measures and electrophysiological methods prevents drawing solid conclusions. Large prospective studies are needed to consolidate findings concerning electrophysiological markers of clinical and functional outcome.

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“…Such deficits during tone matching have been shown to predict higher-order impairments in working memory, reading, and emotion recognition ( 102 ). Moreover, theta band abnormalities underlying auditory MMN deficits, which have been shown to be modulated by glutamatergic NMDAR drug manipulations in schizophrenia ( 103 , 104 ), are correlated with executive functions, including working memory ( 100 , 105 ), as well as non-verbal memory and social cognition ( 100 ) in patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia

et al. 2020

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Long-term potentiation (LTP) is a form of experience-dependent synaptic plasticity mediated by glutamatergic transmission at N-methyl-D-aspartate receptors (NMDARs). Impaired neuroplasticity has been implicated in the pathophysiology of schizophrenia, possibly due to underlying NMDAR hypofunction. Analogous to the high frequency electrical stimulation used to induce LTP in vitro and in vivo in animal models, repeated high frequency presentation of a visual stimulus in humans in vivo has been shown to induce enduring LTP-like neuroplastic changes in electroencephalography (EEG)-based visual evoked potentials (VEPs) elicited by the stimulus. Using this LTP-like visual plasticity paradigm, we previously showed that visual high-frequency stimulation (VHFS) induced sustained changes in VEP amplitudes in healthy controls, but not in patients with schizophrenia. Here, we extend this prior work by re-analyzing the EEG data underlying the VEPs, focusing on neuroplastic changes in stimulus-evoked EEG oscillatory activity following VHFS. EEG data were recorded from 19 patients with schizophrenia and 21 healthy controls during the visual plasticity paradigm. Event-related EEG oscillations (total power, intertrial phase coherence; ITC) elicited by a standard black and white checkerboard stimulus (~0.83 Hz, several 2-min blocks) were assessed before and after exposure to VHFS with the same stimulus (~8.9 Hz, 2 min). A cluster-based permutation testing approach was applied to time-frequency data to examine LTP-like plasticity effects following VHFS. VHFS enhanced theta band total power and ITC in healthy controls but not in patients with schizophrenia. The magnitude and phase synchrony of theta oscillations in response to a visual stimulus were enhanced for at least 22 min following VHFS, a frequency domain manifestation of LTP-like visual cortical plasticity. These theta oscillation changes are deficient in patients with schizophrenia, consistent with hypothesized NMDA receptor dysfunction.

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Differential of Frequency and Duration Mismatch Negativity and Theta Power Deficits in First-Episode and Chronic Schizophrenia

Cited by 25 publications

References 50 publications

NMDA Receptor Antagonist Effects on Speech-Related Mismatch Negativity and Its Underlying Oscillatory and Source Activity in Healthy Humans

NMDA Receptor Antagonist Effects on Speech-Related Mismatch Negativity and Its Underlying Oscillatory and Source Activity in Healthy Humans

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia

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