Differential neural responding to affective stimuli in 6- to 8-year old children at high familial risk for depression: Associations with behavioral reward seeking

Morgan, Judith K.; Silk, Jennifer S.; Woods, Brittany K.; Forbes, Erika E.

doi:10.1016/j.jad.2019.06.058

Cited by 20 publications

(8 citation statements)

References 52 publications

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“…However, there is some agreement across studies on functional reward processing. Consistent reports of reduced striatal activation during reward anticipation appear in FHR children and adolescents ( Gotlib et al, 2010 , Morgan et al, 2019 , Olino et al, 2015 , Sharp et al, 2014 , Wiggins et al, 2017 ). This is concordant with the reduced striatal activation associated with increased depression severity and the altered activation that is common in adults with depression ( Arrondo et al, 2015 , Segarra et al, 2016 , Zhang et al, 2018 ).…”

Section: Discussionmentioning

confidence: 59%

“…The three studies investigating reward-task functional connectivity in young offspring of depressed mothers focused on the neural response elicited by gaining a reward. Overall, two out of the three studies detected hypoactivation of the striatum, with another reported hypoactivation of the dorsolateral PFC and parahippocampal gyri ( Luking et al, 2016 , Morgan et al, 2019 , Wiggins et al, 2017 ). Furthermore, one of those studies observed that hypoactivation of the striatum was associated with reduced reward-seeking behavior in FHR children ( Morgan et al, 2019 ).…”

Section: Resultsmentioning

confidence: 88%

See 1 more Smart Citation

Neural markers of familial risk for depression – A systematic review

Nazarova

Schmidt

Cookey

et al. 2022

Developmental Cognitive Neuroscience

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Section: Discussionmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 88%

Neural markers of familial risk for depression – A systematic review

Nazarova

Schmidt

Cookey

et al. 2022

Developmental Cognitive Neuroscience

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“…A diminished ability to respond adaptively to negative feedback may reflect children's emerging depression risk. Morgan et al (2019) study of never-depressed 6-to 8-year-olds at high familial risk for depression found lower DS activity during rewarding social stimuli was associated with decreased reward-seeking activity. Although we did not measure reward-processing or goal-directed behavior in the current study, our findings complement these studies, suggesting that diminished DS activity in the context of depression risk may be related to decreases in goal-directed behavior.…”

Section: Discussionmentioning

confidence: 91%

Children’s neural reactivity to maternal praise and criticism: Associations with early depressive symptoms and maternal depression

Vandermeer

Liu²,

Ali³

et al. 2022

Dev Psychopathol

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Caregiving experiences are implicated in children’s depression risk; however, children’s neural reactivity to positive and negative feedback from mothers, a potential mediator of depression risk, is poorly understood. In a sample of 81 children (Mage = 11.12 years, SDage = 0.63), some of whom were recruited based on a maternal history of depression (n = 29), we used fMRI to characterize children’s neural responses to maternal praise and criticism. Maternal history of depression was unrelated to children’s brain activity during both the praise and criticism conditions; however, ROI analyses showed that children’s self-reported depressive symptoms were negatively associated with functional activity in the left anterior insula and right putamen while hearing maternal criticism. Whole-brain analyses showed that children’s depressive symptoms were positively associated with left inferior frontal gyrus activity while listening to maternal praise. These findings complement past work implicating these brain regions in the processing of emotionally salient stimuli, reward processing, and internal speech. Given associations between early depressive symptoms and later disorder, findings suggest that maladaptive neural processing of maternal feedback may contribute to children’s early emerging risk for depression.

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“…Our results may reflect a diminished ability to respond adaptively to negative feedback that ultimately increases children's depression risk. Morgan, Silk, Woods, & Forbes' (2019) study of never-depressed 6-to 8-yearolds at high familial risk for depression found lower DS activity during rewarding social stimuli was associated with decreased reward-seeking activity. While we did not measure reward processing in the current study, our findings complement this work showing that diminished DS activity in the context of depression risk is related to decreases in goal-directed behaviour.…”

Section: Discussionmentioning

confidence: 91%

Children’s Neural Reactivity to Maternal Praise and Criticism: Associations with Early Depressive Symptoms and Maternal Depression

Vandermeer¹,

P²,

Om³

et al. 2021

Preprint

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Maladaptive responses to early caregiving are implicated in depression; however, children’s neural reactivity to positive and negative feedback from mothers is poorly understood. We used fMRI to characterize 81 never-depressed children’s (Mage = 11.12 years, SDage = .63) neural responses to hearing their mothers’ praise and criticism. Maternal history of depression was unrelated to children’s brain activity during both the praise and criticism conditions; however, ROI analyses showed that children’s self-reported depressive symptoms were negatively associated with functional activity in the left anterior insula and right putamen while hearing maternal criticism. Whole-brain analyses showed that children’s depressive symptoms were positively associated with left inferior frontal gyrus activity while listening to maternal praise. These findings complement past work implicating these brain regions in emotional salience, reward processing, and internal speech, respectively. Findings further suggest that maladaptive neural processing of maternal feedback may contribute to children’s early emerging depressive symptoms.

show abstract

Differential neural responding to affective stimuli in 6- to 8-year old children at high familial risk for depression: Associations with behavioral reward seeking

Cited by 20 publications

References 52 publications

Neural markers of familial risk for depression – A systematic review

Neural markers of familial risk for depression – A systematic review

Children’s neural reactivity to maternal praise and criticism: Associations with early depressive symptoms and maternal depression

Children’s Neural Reactivity to Maternal Praise and Criticism: Associations with Early Depressive Symptoms and Maternal Depression

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