Differential navigational strategies during spatial learning in a new modified version of the Oasis maze

Alzheimer’s Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent

“…The Oasis maze—a dry version of the classical Morris water maze memory task—was used to evaluate the hippocampal-dependent spatial memory of rats, as previously described ( 39 – 41 ). Animal behavior was recorded with a video camera installed in the zenithal position, and video recordings were analyzed using the Virtual Dub software (Microsoft Windows, Microsoft Corporation, Redmond, WA).…”

“…The Oasis maze-a dry version of the classical Morris water maze memory task-was used to evaluate the hippocampaldependent spatial memory of rats, as previously described (39)(40)(41).…”

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

“…Non-transgenic animal models of AD are also available for the study of AD. Bilateral stereotaxic injection of Aβ(1–42) oligomers into the hippocampus of Sprague–Dawley rats induces memory deficits and histopathological alterations in the brains of animals ( More et al, 2018 ; Concha-Miranda et al, 2020 ). In this animal model the administration of intraperitoneal nicotinamide for 7 days was associated with downregulation of the elevated levels of PARP-1, as well as of NF-κB, p53, Bax and oxidative stress parameters ( Turunc Bayrakdar et al, 2014 ).…”