Differential mortality and lesion responses to reticuloendotheliosis virus infection in Marek's disease-resistant and susceptible chicken lines

Scofield, Virginia L.; Spence, Jean L.; Briles, W. E.; Bose, Henry R.

doi:10.1007/bf01844003

Cited by 7 publications

(2 citation statements)

References 19 publications

(13 reference statements)

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“…Further, differences between chicken lines in mortality and lesion responses, induced presumably by defective REV strain T, have been described (Scofield et al, 1978). However, resistance of chicken lines to REV infection or REV-induced bursa-associated lymphomas has not been documented.…”

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confidence: 98%

“…Differences between chicken lines in susceptibility to ALV-induced lymphomas have been described (Crittenden et al, 1972;Purchase and Gilmour, 1975;Baba and Humpheries, 1984). Further, differences between chicken lines in mortality and lesion responses, induced presumably by defective REV strain T, have been described (Scofield et al, 1978). However, resistance of chicken lines to REV infection or REV-induced bursa-associated lymphomas has not been documented.…”

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Resistance of line 6₃ chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas

Fadly

Witter

1986

Intl Journal of Cancer

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Chickens of lines 6(3) and 151(5) X 7(1) were inoculated with the chick syncytial strain of reticuloendotheliosis virus (REV) or with the Rous-associated virus-I of avian leukosis virus (ALV) at hatching. At 4, 10, 16, and 36 weeks post inoculation (PI), chickens were tested for REV- and ALV-induced viremia and antibody. The incidence of REV- or ALV-induced bursa-associated lymphomas in line 6(3) chickens was compared with that in line 151(5) X 7(1) chickens. Inoculation of REV at hatching resulted in immunological tolerance to the virus in line 6(3) but not in line 151(5) X 7(1) chickens. Between 70% and 100% of line 6(3) chickens remained viremic and lacked REV antibody throughout the experimental period of 36 weeks. In contrast, ALV-inoculated chickens of both lines had antibody by 16 weeks PI. The frequencies of REV- and ALV-induced bursa-associated lymphomas in line 6(3) chickens were significantly lower than in line 151(5) X 7(1) chickens. Further, the incidence of bursa-associated lymphomas induced by REV in line 151(5) X 7(1) chickens was significantly lower than that induced by ALV. These results suggest that: (1) the genetic constitution of the host may influence the immunological response to REV infection; (2) chickens resistant to ALV-induced bursa-associated lymphomas are equally resistant to such lymphomas induced by another unrelated avian retrovirus, REV; and (3) ALV is a more potent inducer of bursa-associated lymphomas than REV.

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confidence: 98%

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Resistance of line 6₃ chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas

Fadly

Witter

1986

Intl Journal of Cancer

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Neoplastic Diseases

Nair¹,

Gimeno²,

Dunn³

et al. 2019

Diseases of Poultry

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Neoplastic Diseases

2013

Diseases of Poultry

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Differential mortality and lesion responses to reticuloendotheliosis virus infection in Marek's disease-resistant and susceptible chicken lines

Cited by 7 publications

References 19 publications

Resistance of line 6₃ chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas

Resistance of line 6₃ chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas

Neoplastic Diseases

Neoplastic Diseases

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Differential mortality and lesion responses to reticuloendotheliosis virus infection in Marek's disease-resistant and susceptible chicken lines

Cited by 7 publications

References 19 publications

Resistance of line 63 chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas

Resistance of line 63 chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas

Neoplastic Diseases

Neoplastic Diseases

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Resistance of line 6₃ chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas

Resistance of line 6₃ chickens to reticuloendotheliosis‐virus‐induced bursa‐associated lymphomas