Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease

Hirschmann, Jan V.; Özkurt, Tolga Esat; Butz, Markus; Homburger, M.; Elben, Saskia; Hartmann, Christian; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons

doi:10.1016/j.neuroimage.2012.11.036

Cited by 106 publications

(121 citation statements)

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“…Another MEG-LFP study, analyzing resting state data, observed beta coherence between STN and ipsilateral sensorimotor and premotor regions, and alpha coherence between STN and temporal regions (Hirschmann et al, 2011). This group later reported that the beta range coherence was reduced by movement, but the superior temporal gyrus-STN alpha band coherence was modulated neither by movement nor by medication (Hirschmann et al, 2013). Using a directed transfer function to calculate bidirectional information flow in EEG and STN-LFP data sets, a different study found beta frequency coherence was greater between cortex and STN at rest than during movement, and gamma coherence was greater in the medication on state compared with the off state (Lalo et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Task specific inter-hemispheric coupling in human subthalamic nuclei

Darvas

Hebb

2014

Front. Hum. Neurosci.

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Cortical networks and quantitative measures of connectivity are integral to the study of brain function. Despite lack of direct connections between left and right subthalamic nuclei (STN), there are apparent physiological connections. During clinical examination of patients with Parkinson’s disease (PD), this connectivity is exploited to enhance signs of PD, yet our understanding of this connectivity is limited. We hypothesized that movement leads to synchronization of neural oscillations in bilateral STN, and we implemented phase coherence, a measure of phase-locking between cortical sites in a narrow frequency band, to demonstrate this synchronization. We analyzed task specific phase synchronization and causality between left and right STN local field potentials (LFPs) recorded from both hemispheres simultaneously during a cued movement task in four subjects with PD who underwent Deep Brain Stimulation (DBS) surgery. We used a data driven approach to determine inter-hemispheric channel pairs and frequencies with a task specific increase in phase locking.We found significant phase locking between hemispheres in alpha frequency (8–12 Hz) in all subjects concurrent with movement of either hand. In all subjects, phase synchronization increased over baseline upon or prior to hand movement onset and lasted until the motion ceased. Left and right hand movement showed similar patterns. Granger causality (GC) at the phase-locking frequencies between synchronized electrodes revealed a unidirectional causality from right to left STN regardless of which side was moved.Phase synchronization across hemispheres between basal ganglia supports existence of a bilateral network having lateralized regions of specialization for motor processing. Our results suggest this bilateral network is activated by a unilateral motor program. Understanding phase synchronization in natural brain functions is critical to development of future DBS systems that augment goal directed behavioral function.

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Section: Discussionmentioning

confidence: 99%

Task specific inter-hemispheric coupling in human subthalamic nuclei

Darvas

Hebb

2014

Front. Hum. Neurosci.

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“…Put together, these two cases suggest that acute OCD symptoms may be related to abnormally high oscillatory activity in the STN, particularly in the left hemisphere and in the delta-alpha (1e12 Hz) frequency range. In PD, increased corticosubthalamic oscillatory activity in the alpha-beta bands (8e30 Hz) correlates with akinesia (Hirschmann et al, 2013). In OCD, increased oscillatory activity has also been observed in the STN and was found to correlate with the severity of OCD (Welter et al, 2011).…”

Section: Patient Laterality Dbs Contactmentioning

confidence: 99%

Changes of oscillatory activity in the subthalamic nucleus during obsessive-compulsive disorder symptoms: Two case reports

Bastin

Polosan

Piallat

et al. 2014

Cortex

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Deep brain stimulation a b s t r a c tDeep brain stimulation (DBS) of the subthalamic nucleus (STN) has positive and negative effects on mood and cognition, as shown in patients suffering from Parkinson's disease (PD) and severe obsessive-compulsive disorders (OCD). Such behavioural and clinical effects suggest that the STN has an important function in limbic circuitry, which still needs to be clarified from electrophysiological recordings. Here we report two exceptional cases of OCD patients in whom local field potentials (LFP) of the anterior STN were directly recorded during acute obsessive-compulsive symptoms. We found significant symptomrelated changes in different frequency bands, with no clear preferential oscillatory pattern. The overall modified STN activity during OCD symptoms suggests a mixture of both pathological and compensatory mechanisms that would reflect the maintenance of an over stable motor/cognitive/emotional set. Whether this activity propagates throughout the entire cognitive-limbic loops that are impaired in OCD is an interesting question for future research in larger series of patients.ª 2013 Elsevier Ltd. All rights reserved. Research in how the brain processes information is important for understanding obsessive-compulsive disorder (OCD).Beyond factors such as attention, learning, memory that are known to be involved in OCD psychopathology, emotional processing, namely affective and reward processing, depends on the involvement of specific neural networks within and beyond the cortico-striato-thalamo-cortical circuits in the context of specific cognitive-affective paradigms (Becker et al., 2013;Cannistraro et al., 2004;Fitzgerald et al., 2005; van den Heuvel et al., 2005;Milad et al., 2013).Recently it has been shown that severe refractory OCD symptoms can be improved by high frequency stimulation of the subthalamic nucleus (STN) (Chabardè s et al., 2012;Fontaine et al., 2004;Mallet et al., 2008). The STN is a key * Corresponding author. Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini e Bâ t EJ Safra e CHU, 38700 La Tronche, France.E-mail address: julien.bastin@ujf-grenoble.fr (J. Bastin).Available online at www.sciencedirect.com ScienceDirectJournal homepage: www.elsevier.com/locate/cortex c o r t e x 6 0 ( 2 0 1 4 ) 1 4 5 e1 5 0 0010-9452/$ e see front matter ª

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“…PD patients without DBS would have had to endure a full night and half a day off dopaminergic medication, which would have been a challenging task for these patients (matched on disease progression with the DBS cohort), compared to which patients in our cohort had to endure ~2 hours in the completely untreated condition under the supervision of a movement disorders specialist. One alternative to complete withdrawal overnight for PD patients without DBS would have been to keep the patients under subcutaneous medication (apomorphine) (Hirschmann et al, 2011(Hirschmann et al, , 2013 for 12-24 hours prior to the experiment, but this would still have been a drastic intervention in the patients' well-being when they would "merely" serve as control patients.…”

Section: Control Groupmentioning

confidence: 99%

“…There is substantial work on the mechanism of DBS and the possible neural networks and circuits that DBS influences using animal studies (Chomiak and Hu, 2007;Li et al, 2007;Gradinaru et al, 2009) as well as intra-operative and post-operative human studies (Airaksinen et al, 2011;Hirschmann et al, 2011Hirschmann et al, , 2013Walker et al, 2012;de Hemptinne et al, 2015).…”

Section: Effect-mechanisms Of Dbsmentioning

confidence: 99%

“…They have showed varied effects of treatments (Abbruzzese and Berardelli, 2003;Conte et al, 2013;Patel et al, 2014), triggering electrophysiological investigations on changes in the cortical and sub-cortical structures during motor tasks (Salenius et al, 2002;Brücke et al, 2008;Hirschmann et al, 2011Hirschmann et al, , 2013 Introduction Introduction suffers from methodological issues (Salenius et al, 2002;Park et al, 2009;Hirschmann et al, 2013;Airaksinen et al, 2015;Cao et al, 2015Cao et al, , 2017Oswal et al, 2016). …”

Section: Chapter -1 Introductionmentioning

confidence: 99%

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Neuromagnetic investigations of mechanisms and effects of STN-DBS and medication in Parkinson's disease

Sridharan¹

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Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease

Cited by 106 publications

References 58 publications

Task specific inter-hemispheric coupling in human subthalamic nuclei

Task specific inter-hemispheric coupling in human subthalamic nuclei

Changes of oscillatory activity in the subthalamic nucleus during obsessive-compulsive disorder symptoms: Two case reports

Neuromagnetic investigations of mechanisms and effects of STN-DBS and medication in Parkinson's disease

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