Differential modulation of sensory response dynamics by cilia structure and intraflagellar transport within and across chemosensory neurons
Alison Philbrook,
Michael P. O’Donnell,
Laura Grunenkovaite
et al.
Abstract:Sensory neurons contain morphologically diverse primary cilia that are built by intraflagellar transport (IFT) and house sensory signaling molecules. Since both ciliary structural and signaling proteins are trafficked via IFT, it has been challenging to decouple the contributions of IFT and cilia structure to neuronal responses. By acutely inhibiting IFT without altering cilia structure and vice versa, here we describe the differential roles of ciliary trafficking and sensory ending morphology in shaping chemo… Show more
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