Differential modulation of phasic and tonic inhibition underlies serotonergic suppression of long-term potentiation in the rat visual cortex

Jang, Hyun‐Jong; Cho, Kwang Hyun; Joo, Kayoung; Kim, M.-J.; Rhie, Duck-Joo

doi:10.1016/j.neuroscience.2015.06.018

Cited by 7 publications

(8 citation statements)

References 52 publications

(80 reference statements)

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“…CaMKII) [7]. However, whereas in visual cortex 5-HT decreases tonic inhibition via a 5-HT 1A R-dependent suppression of protein kinase A (PKA) activity) [7], we could not detect any effect on the tonic current by 5-HT or 5-HT 1A/7 R activation in the dLGN. Moreover, our study is in agreement with previous in vivo studies in which stimulation of the dorsal raphe nucleus decreased TC neuron firing in the dLGN [8], suggesting 5-HT had an inhibitory action.…”

contrasting

confidence: 62%

“…sIPSCs recorded in the different experimental conditions were collected before GBZ application and analyzed as previously described [6]. CaMKII) [7]. However, whereas in visual cortex 5-HT decreases tonic inhibition via a 5-HT 1A R-dependent suppression of protein kinase A (PKA) activity) [7], we could not detect any effect on the tonic current by 5-HT or 5-HT 1A/7 R activation in the dLGN.…”

mentioning

confidence: 97%

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Differential Control by 5‐HT and 5‐HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus

Crunelli

Giovanni

2015

CNS Neurosci Ther

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confidence: 62%

mentioning

confidence: 97%

Differential Control by 5‐HT and 5‐HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus

Crunelli

Giovanni

2015

CNS Neurosci Ther

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“…To our knowledge, there are no similar detailed studies in the visual cortex of the rodent brain. Both receptors inhibit NMDA-induced LTP in visual cortex via different mechanisms (Jang et al, 2015Kim et al, 2006. Interestingly, 5-HT 1A -R activation evokes plasticity phenomena in adult rats (Maya-Vetencourt et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

The serotonergic hallucinogen 5-methoxy-N,N-dimethyltryptamine disrupts cortical activity in a regionally-selective manner via 5-HT 1A and 5-HT 2A receptors

et al. 2016

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5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen, acting as a non-selective serotonin 5-HT(1A)/5-HT(2A)-R agonist. Psychotomimetic agents such as the non-competitive NMDA-R antagonist phencyclidine and serotonergic hallucinogens (DOI and 5-MeO-DMT) disrupt cortical synchrony in the low frequency range (<4 Hz) in rat prefrontal cortex (PFC), an effect reversed by antipsychotic drugs. Here we extend these observations by examining the effect of 5-MeO-DMT on low frequency cortical oscillations (LFCO, <4 Hz) in PFC, visual (V1), somatosensory (S1) and auditory (Au1) cortices, as well as the dependence of these effects on 5-HT(1A)-R and 5-HT(2A)-R, using wild type (WT) and 5-HT(2A)-R knockout (KO2A) anesthetized mice. 5-MeO-DMT reduced LFCO in the PFC of WT and KO2A mice. The effect in KO2A mice was fully prevented by the 5-HT(1A)-R antagonist WAY-100635. Systemic and local 5-MeO-DMT reduced 5-HT release in PFC mainly via 5-HT(1A)-R. Moreover, 5-MeO-DMT reduced LFCO in S1, Au1 and V1 of WT mice and only in V1 of KO2A mice, suggesting the involvement of 5-HT(1A)-R activation in the 5-MeO-DMT-induced disruption of V1 activity. In addition, antipsychotic drugs reversed 5-MeO-DMT effects in WT mice. The present results suggest that the hallucinogen action of 5-MeO-DMT is mediated by simultaneous alterations of the activity of sensory (S1, Au1, V1) and associative (PFC) cortical areas, also supporting a role of 5-HT(1A)-R stimulation in V1 and PFC, in addition to the well-known action on 5-HT(2A)-R. Moreover, the reversal by antipsychotic drugs of 5-MeO-DMT effects adds to previous literature supporting the usefulness of the present model in antipsychotic drug development.

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“…In kitten visual cortex, 5-HT is thought to be necessary for OD plasticity [ 17 44 ] and long-term synaptic plasticity can be facilitated by 5-HT [ 45 ]. However, long-term synaptic plasticity was suppressed by 5-HT in the visual cortex of juvenile rats [ 14 46 47 ]. In the more aged rats, 5-HT rather enhanced long-term synaptic plasticity [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of GluN2B Subunit-Containing NMDA Receptor Underlies Serotonergic Regulation of Long-Term Potentiation after Critical Period in the Rat Visual Cortex

Joo

Rhie

Jang

2015

Korean J Physiol Pharmacol

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Serotonin [5-hydroxytryptamine (5-HT)] regulates synaptic plasticity in the visual cortex. Although the effects of 5-HT on plasticity showed huge diversity depending on the ages of animals and species, it has been unclear how 5-HT can show such diverse effects. In the rat visual cortex, 5-HT suppressed long-term potentiation (LTP) at 5 weeks but enhanced LTP at 8 weeks. We speculated that this difference may originate from differential regulation of neurotransmission by 5-HT between the age groups. Thus, we investigated the effects of 5-HT on apha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-, γ-aminobutyric acid receptor type A (GABAAR)-, and N-methyl-D-aspartic acid receptor (NMDAR)-mediated neurotransmissions and their involvement in the differential regulation of plasticity between 5 and 8 weeks. AMPAR-mediated currents were not affected by 5-HT at both 5 and 8 weeks. GABAAR-mediated currents were enhanced by 5-HT at both age groups. However, 5-HT enhanced NMDAR-mediated currents only at 8 weeks. The enhancement of NMDAR-mediated currents appeared to be mediated by the enhanced function of GluN2B subunit-containing NMDAR. The enhanced GABAAR- and NMDAR-mediated neurotransmissions were responsible for the suppression of LTP at 5 weeks and the facilitation of LTP at 8 weeks, respectively. These results indicate that the effects of 5-HT on neurotransmission change with development, and the changes may underlie the differential regulation of synaptic plasticity between different age groups. Thus, the developmental changes in 5-HT function should be carefully considered while investigating the 5-HT-mediated metaplastic control of the cortical network.

show abstract

Differential modulation of phasic and tonic inhibition underlies serotonergic suppression of long-term potentiation in the rat visual cortex

Cited by 7 publications

References 52 publications

Differential Control by 5‐HT and 5‐HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus

Differential Control by 5‐HT and 5‐HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus

The serotonergic hallucinogen 5-methoxy-N,N-dimethyltryptamine disrupts cortical activity in a regionally-selective manner via 5-HT 1A and 5-HT 2A receptors

Enhancement of GluN2B Subunit-Containing NMDA Receptor Underlies Serotonergic Regulation of Long-Term Potentiation after Critical Period in the Rat Visual Cortex

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