Differential mitochondrial dysregulation by exposure to individual organochlorine pesticides (OCPs) and their mixture in zebrafish embryos

Deterioration of Cytochrome C Content and Mitochondrial Dysfunction in Brain of Male Rats after Sub-Chronic Exposure to Thiamethoxam and Protective Role of N- Acetylcysteine

“…Agreeing with Karami-Mohajeri et al (2013), mevinphos acute exposure resulted depletion in the NADH cytochrome C reductase and succinate cytochrome C reductase (Complexes II and III) in pheochromocytoma cell line. Unlike, Lee et al (2021) proposed that two chlorinated hydrocarbons, chlordane and βhexachlorocyclohexane, were linked to increased mitochondrial NADH dehydrogenase (complex I) and cytochrome c reductase (complex III) specific activity in treated zebrafish embryos.…”

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species

“…HL-7702 cells were treated with DMSO/chlorpropamide (200 μmol/L) for three days. The NADH dehydrogenase activity was measured by the oxidation of NADH at 340 nm as described earlier 42 . For assay buffer, NADH (0.1 mmol/L), BSA (3 mg/mL), ubiquinone (0.06 mmol/L) and antimycin A (4 μmol/L) was diluted by 5 × PBS and adjusted to pH 7.5.…”

Chlorfenapyr Induce Oxidative Phosphorylation Deficiency in Exposed Rat and the Quinoa Effective Role

“…Furthermore, Abbassy et al, (2014) observed a significant reduction in GSH level after dosing rats with 2.6 mg/kg bw of lambda cyhalothrin for 6 weeks (3doses/week). Likewise, chlordane and βhexachlorocyclohexane (-HCH) were linked to lower mitochondrial GSH levels in exposed zebrafish embryos, according to Lee et al (2021) study. Reduced GSH levels in mitochondria lead to an increase in H2O2 production, which can promote lipid peroxidation, cell membrane damage, and tissue damage (Martín et al, 2000;Şener et al, 2005).…”

“…In line with Karami-Mohajeri and Abdollahi (2013) who reviewed that mevinphos acute exposure resulted in depletion of NADH cytochrome C reductase (Complexes I and III), and succinate cytochrome C reductase (Complexes II and III) in pheochromocytoma cell lines. In contrast, Lee et al (2021) postulated that two chlorinated hydrocarbons compounds; chlordane and βhexachlorocyclohexane (β-HCH), were associated with increased the specific activity of mitochondrial complexes I and III of exposed zebrafish embryos.…”