Differential MicroRNA Expressions in Human Peripheral Blood Mononuclear Cells Are Predictive of Renal Allograft Function

Li, F.; Qian, Wangsheng; Quan, Xin; Yang, Hui‐Li; Zhao, Gaoping

doi:10.1016/j.transproceed.2019.01.051

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…Their overexpression during AR appears to not be specific to kidney transplants since similar results have also been obtained in murine liver transplant models [87,88]. Other studies report that the overexpression of miR-223 is associated with a worse kidney function during the first few weeks post-transplant [89].…”

Section: Microrna Molecules and Their Role In Transplantationsupporting

confidence: 58%

MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

Legaz,

Jimenez-Coll,

González-López

et al. 2024

Biomedicines

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Allograft rejection is a widespread complication in allograft recipients with chronic kidney disease. Undertreatment of subclinical and clinical rejection and later post-transplant problems are caused by an imperfect understanding of the mechanisms at play and a lack of adequate diagnostic tools. Many different biomarkers have been analyzed and proposed to detect and monitor these crucial events in transplant outcomes. In this sense, microRNAs may help diagnose rejection or tolerance and indicate appropriate treatment, especially in patients with chronic allograft rejection. As key epigenetic regulators of physiological homeostasis, microRNAs have therapeutic potential and may indicate allograft tolerance or rejection. However, more evidence and clinical validation are indispensable before microRNAs are ready for clinical prime time.

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Section: Microrna Molecules and Their Role In Transplantationsupporting

confidence: 58%

MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

Legaz,

Jimenez-Coll,

González-López

et al. 2024

Biomedicines

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“…The first four of these miRNAs were also present in SEVs, but they were not significantly upregulated in the SCR patients. In the literature, miR-142-5p and miR-142-3p have already been reported to be associated with acute renal allograft rejection [37,38]. In addition, a high level of miR-142-3p has been detected in the leucocyte and urinary samples of adult transplanted patients with acute rejection and tubular necrosis [39].…”

Section: Discussionmentioning

confidence: 99%

New Insights into Pediatric Kidney Transplant Rejection Biomarkers: Tissue, Plasma and Urine MicroRNAs Compared to Protocol Biopsy Histology

Carraro,

De Gaspari,

Antoniello

et al. 2024

IJMS

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The early identification of a subclinical rejection (SCR) can improve the long-term outcome of the transplanted kidney through intensified immunosuppression. However, the only approved diagnostic method is the protocol biopsy, which remains an invasive method and not without minor and/or major complications. The protocol biopsy is defined as the sampling of allograft tissue at pre-established times even in the absence of an impaired renal function; however, it does not avoid histological damage. Therefore, the discovery of new possible biomarkers useful in the prevention of SCR has gained great interest. Among all the possible candidates, there are microRNAs (miRNAs), which are short, noncoding RNA sequences, that are involved in mediating numerous post-transcriptional pathways. They can be found not only in tissues, but also in different biological fluids, both as free particles and contained in extracellular vesicles (EVs) released by different cell types. In this study, we firstly performed a retrospective miRNA screening analysis on biopsies and serum EV samples of 20 pediatric transplanted patients, followed by a second screening on another 10 pediatric transplanted patients’ urine samples at one year post-transplant. In both cohorts, we divided the patients into two groups: patients with histological SCR and patients without histological SCR at one year post-transplantation. The isolated miRNAs were analyzed in an NGS platform to identify different expressions in the two allograft states. Although no statistical data were found in sera, in the tissue and urinary EVs, we highlighted signatures of miRNAs associated with the histological SCR state.

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“…The elevations of miR-142-5p and miR-142-3p were also associated with later cystatin C increases. These results indicate that miRNAs in PBMC may be useful in predicting renal allograft dysfunction than conventional biomarkers, such as serum creatinine and cystatin C (89). Recently, exosomes, a type of extracellular vesicle carrying abundant contents including miRNAs, have attracted extensive interest (120).…”

Section: Ischemia-reperfusion Injury and Delayed Graft Functionmentioning

confidence: 96%

Epigenetic Regulation in Kidney Transplantation

et al. 2022

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Kidney transplantation is a standard care for end stage renal disease, but it is also associated with a complex pathogenesis including ischemia-reperfusion injury, inflammation, and development of fibrosis. Over the past decade, accumulating evidence has suggested a role of epigenetic regulation in kidney transplantation, involving DNA methylation, histone modification, and various kinds of non-coding RNAs. Here, we analyze these recent studies supporting the role of epigenetic regulation in different pathological processes of kidney transplantation, i.e., ischemia-reperfusion injury, acute rejection, and chronic graft pathologies including renal interstitial fibrosis. Further investigation of epigenetic alterations, their pathological roles and underlying mechanisms in kidney transplantation may lead to new strategies for the discovery of novel diagnostic biomarkers and therapeutic interventions.

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Differential MicroRNA Expressions in Human Peripheral Blood Mononuclear Cells Are Predictive of Renal Allograft Function

Cited by 5 publications

References 20 publications

MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

New Insights into Pediatric Kidney Transplant Rejection Biomarkers: Tissue, Plasma and Urine MicroRNAs Compared to Protocol Biopsy Histology

Epigenetic Regulation in Kidney Transplantation

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