Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington’s disease
Ayaz Belkozhayev,
Raigul Niyazova,
Mohammad Amjad Kamal
et al.
Abstract:Huntington’s disease (HD) is caused by an expansion of CAG trinucleotide repeat in the HTT gene; the exact pathogenesis of HD currently remains unclear. One of the promising directions in the study of HDs is to determine the molecular mechanism underlying the development and role of microRNAs (miRNAs). This study aimed to identify the profile of miRNAs in an HD human cell line model as diagnostic biomarkers for HD. To study HD, the human SH-SY5Y HD cell model is based on the expression of two different forms: … Show more
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