Differential microfluidic sensor on printed circuit board for biological cells analysis

Shi, Dongyuan; Guo, Jinhong; Chen, Liang; Xia, Chuncheng; Yu, Zhe-Feng; Ai, Ye; Li, Chang Ming; Kang, Yuejun; Wang, Zhiming

doi:10.1002/elps.201400524

Cited by 21 publications

(12 citation statements)

References 17 publications

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“…Nevertheless, it has been demonstrated that by replacing the meander lines with artificial lines, sensitivity optimization can be made compatible with moderate or even small sizes [12,60]. Many differential sensors based on resonator-loaded lines (the interest in this work) have been reported, including microfluidic sensors for liquid characterization [61][62][63][64][65][66][67]. In some realizations, the output variable is the cross-mode transmission coefficient [62][63][64][65][66][67], proportional to the difference between the transmission coefficients of both sensing lines, provided such lines are uncoupled.…”

Section: Classification Of Planar Microwave Resonant Sensorsmentioning

confidence: 99%

Planar Microwave Resonant Sensors: A Review and Recent Developments

et al. 2020

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Microwave sensors based on electrically small planar resonant elements are reviewed in this paper. By virtue of the high sensitivity of such resonators to the properties of their surrounding medium, particularly the dielectric constant and the loss factor, these sensors are of special interest (although not exclusive) for dielectric characterization of solids and liquids, and for the measurement of material composition. Several sensing strategies are presented, with special emphasis on differential-mode sensors. The main advantages and limitations of such techniques are discussed, and several prototype examples are reported, mainly including sensors for measuring the dielectric properties of solids, and sensors based on microfluidics (useful for liquid characterization and liquid composition). The proposed sensors have high potential for application in real scenarios (including industrial processes and characterization of biosamples).

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Section: Classification Of Planar Microwave Resonant Sensorsmentioning

confidence: 99%

Planar Microwave Resonant Sensors: A Review and Recent Developments

et al. 2020

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“…But the early traditional cell experiments used only standard benchtop instruments, making cell analysis only allowed to be performed in professional laboratories [33][34][35][36]. Recently, many researchers use PCB-based resistance sensors or capacitive sensors to build a Lab-on-PCB platform to count cells or detect cell viability for disease diagnosis and drug toxicity detection in a low-cost and mini-size way [37][38][39][40][41][42][43].…”

Section: Cell Analysismentioning

confidence: 99%

The review of Lab‐on‐PCB for biomedical application

et al. 2020

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Prevention of infectious diseases, diagnosis of diseases, and determination of treatment options all rely on biosensors to detect and analyze biomarkers, which are usually divided into four parts: cell analysis, biochemical analysis, immunoassay, and molecular diagnosis. However, traditional biosensing devices are expensive, bulky, and require a lot of time to detect, which also limited its application in resource‐limited areas. In recent years, Lab‐on‐PCB, which combines biosensing technology and PCB technology, has been widely used in biomedical applications due to its high integration, personalized design, and easy mass production. Among these Lab‐on‐PCB sensing devices, the PCB circuit plays an important role. It can be directly used as a resistance sensor to count cells, and also used as a control device to automatically control the detection device. Flexible PCBs can be used to make wearable medical biosensors. In addition, due to the high degree of integration of the PCB circuit, Lab‐on‐PCB can perform multiple inspections on the same platform, which reduces the inspection time equivalently. Therefore, in this review paper, we discuss the application of Lab‐on‐PCB in four analysis methods of cell analysis, biochemical analysis, immunoassay, and molecular diagnosis, and give some suggestions for improvement and future development trends at the end.

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“…100 Disposable PDMS-PCB chips were also reported for electrophoretic separation and amperometric DNA detection 101 or low cost detection and enumeration of circulating tumor cells in a microfluidic impedance cytometer. 102,103 In addition, highly integrated microfluidic components and LoC devices have been developed on PCB substrates for on-chip sample preparation, DNA amplification and detection, by integrating multiple embedded heating and sensing elements together with electrical circuitries on a PCB with a polymeric cover where the microfluidic network (mixers, valves, pumps, etc.) was micromilled.…”

Section: Technology Overview and Demonstrated Prototypesmentioning

confidence: 99%

The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck

2017

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Commercialization of lab-on-a-chip devices is currently the "holy grail" within the μTAS research community. While a wide variety of highly sophisticated chips which could potentially revolutionize healthcare, biology, chemistry and all related disciplines are increasingly being demonstrated, very few chips are or can be adopted by the market and reach the end-users. The major inhibition factor lies in the lack of an established commercial manufacturing technology. The lab-on-printed circuit board (lab-on-PCB) approach, while suggested many years ago, only recently has re-emerged as a very strong candidate, owing to its inherent upscaling potential: the PCB industry is well established all around the world, with standardized fabrication facilities and processes, but commercially exploited currently only for electronics. Owing to these characteristics, complex μTASs integrating microfluidics, sensors, and electronics on the same PCB platform can easily be upscaled, provided more processes and prototypes adapted to the PCB industry are proposed. In this article, we will be reviewing for the first time the PCB-based prototypes presented in the literature to date, highlighting the upscaling potential of this technology. The authors believe that further evolution of this technology has the potential to become a much sought-after standardized industrial fabrication technology for low-cost μTASs, which could in turn trigger the projected exponential market growth of μTASs, in a fashion analogous to the revolution of Si microchips via the CMOS industry establishment.

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Differential microfluidic sensor on printed circuit board for biological cells analysis

Cited by 21 publications

References 17 publications

Planar Microwave Resonant Sensors: A Review and Recent Developments

Planar Microwave Resonant Sensors: A Review and Recent Developments

The review of Lab‐on‐PCB for biomedical application

The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck

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