2007
DOI: 10.1590/s1415-47572007000200004
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Abstract: The annotation and comparative analyses of the genomes of Mycoplasma synoviae and Mycoplasma hyopneumonie, as well as of other Mollicutes (a group of bacteria devoid of a rigid cell wall), has set the grounds for a global understanding of their metabolism and infection mechanisms. According to the annotation data, M. synoviae and M. hyopneumoniae are able to perform glycolytic metabolism, but do not possess the enzymatic machinery for citrate and glyoxylate cycles, gluconeogenesis and the pentose phosphate pat… Show more

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Cited by 20 publications
(15 citation statements)
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“…hyopneumoniae strain 7448 in MHP7448_0087, glyA and sipS genes (Table 3), suggesting that some DNA repeats analysed may be involved in mycoplasma pathogenicity. GTP-binding protein, glycine hydroxymethyltransferase enzyme and signal peptidase I coding genes are important to cell viability and in some cases have already been related to mycoplasma pathogenicity process [5557]. Promoter sequences associated with tandem repeats were present in all regulatory sequences of experimentally tested genes (S2 Table), reinforcing the hypothesis that repetitive elements may be interfering in the promoter region and consequently the transcription of related genes [20, 54].…”
Section: Discussionmentioning
confidence: 61%
“…hyopneumoniae strain 7448 in MHP7448_0087, glyA and sipS genes (Table 3), suggesting that some DNA repeats analysed may be involved in mycoplasma pathogenicity. GTP-binding protein, glycine hydroxymethyltransferase enzyme and signal peptidase I coding genes are important to cell viability and in some cases have already been related to mycoplasma pathogenicity process [5557]. Promoter sequences associated with tandem repeats were present in all regulatory sequences of experimentally tested genes (S2 Table), reinforcing the hypothesis that repetitive elements may be interfering in the promoter region and consequently the transcription of related genes [20, 54].…”
Section: Discussionmentioning
confidence: 61%
“…The differing biochemical activities among Mycoplasma species are vast, but they are united by deficiencies in metabolic capabilities. Mycoplasma species lack pathways for cell wall production, de novo synthesis of purines and pyrimidines, and have truncated respiratory systems to name a few (2,12). Probably the most notable requirement of Mycoplasma species is the need for fatty acids and lipids for membrane synthesis (13,16).…”
Section: Pathogenesismentioning
confidence: 99%
“…Through reductive evolution, the genome of M. hyopneumoniae is quite minimal, lacking main biosynthetic pathways such as purine and pyrimidine synthesis (2). Chronic EP can partially be attributed to the loss of cilia along the tracheal epithelium resulting in a nonfunctional mucociliary elevator and the introduction of secondary pathogens (3).…”
Section: General Introductionmentioning
confidence: 99%
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