Differential macroscopic and histologic features between pituitary adenomas presenting with and without presurgical anterior pituitary dysfunction. A study of 232 patients

Araujo‐Castro, Marta; Caracuel, Ignacio Ruz; Pián, Héctor; Urzaiz, Luis Ley; Berrocal, Víctor Rodríguez

doi:10.1016/j.endien.2020.10.011

Cited by 1 publication

(2 citation statements)

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“…Data were collected from a retrospective database of all patients with PAs who underwent pituitary surgery at two centers (Hospital Universitario Ramón y Cajal, HRC, and Hospital HM Puerta Sur, Madrid, Spain) between 2008-2022, accounting for 374 entries. As we have previously described (21,22), inclusion criteria in the present study were patients with available information about pre-and postoperative clinical, hormonal, ophthalmological, and radiological data, operated by the same experienced pituitary neurosurgeon (VRB) and pathology reports con rming PAs diagnosis. A total of 80 patients with very large (n = 44) or giant (n = 36) PAs and 226 patients in the non-LARGE group who underwent pituitary tumor resection between January 2008 and December 2022 were included in the study.…”

Section: Patientsmentioning

confidence: 99%

“…The histological features evaluated were pituitary hormone immunostaining and proliferation index based on Ki67 immunoexpression as described in our previous study (21). Tumor consistency was classi ed into two groups: "soft", which includes easily aspirated tumors with conventional 8-10 french suction tip, and " brous", which implies that the tumor had to be fragmented previously with ring curettes and occasionally needs extracapsular dissection for its complete removal (31).…”

Section: Surgical and Histological Evaluationmentioning

confidence: 99%

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Clinical presentation and surgical outcomes of very large and giant pituitary adenomas: 80 cases in a cohort study of 306 patients

Pascual-Corrales,

Cancela,

Baonza

et al. 2023

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Purpose To identify differences in the presentation and surgical outcomes between very large (30–39 mm) and giant (≥40mm) (LARGE group) pituitary adenomas (PAs) compared to the smaller group (< 30mm) (non-LARGE group). Methods Eighty patients with very large (n = 44) or giant (n = 36) PAs and 226 patients in the non-LARGE group who underwent tumor resection by pituitary surgery between 2008 and 2023 were studied. Hormonal, radiological, ophthalmological, and pathological data and surgical outcomes were evaluated. Results Preoperatively, patients of the LARGE group presented more frequently with visual impairment (82.5% vs. 22.1%, P < 0.001) and with apoplexy (15.0% vs. 2.7%, P < 0.001) than the non-LARGE group. Moreover, the LARGE group is more commonly associated with preoperative panhypopituitarism (28.8% vs. 6.2%, P < 0.001). This group presented cavernous sinus invasion more frequently (71.3% vs. 23.9%, P < 0.001). The non-LARGE group achieved surgical cure more often than the LARGE group (79.7% vs. 50.0%, P < 0.001), and the rate of major complications was higher in the latest (8.8% vs. 1.3%, P < 0.004). Conclusions PAs ≥30 mm are most frequently accompanied by hormonal dysfunction, cavernous sinus invasion, and visual impairment. All this implies lower resection rates and higher postoperative complications than small adenomas, posing a real surgical challenge.

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Section: Patientsmentioning

confidence: 99%

Section: Surgical and Histological Evaluationmentioning

confidence: 99%