1992
DOI: 10.1159/000126172
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Differential Inhibition of Dopamine and Bromocriptine on Induced Prolactin Release: Multiple Sites for the Inhibition of Dopamine

Abstract: Effects of dopamine and bromocriptine on TRH- or dibutyryladenosine 3’,5’-cyclic monophosphate (dbcAMP)-induced prolactin release from primary cultured rat pituitary cells were studied using a perifusion system. TRH (100 nmol/l) stimulated prolactin release from basal concentrations of 33.8 ± 0.5 to 151.2 ± 28.0 ng/ml (net increase) or 447% increase. Dopamine inhibited the basal release of prolactin throughout the experiment, but TRH (100 nmol/l) was still able to stimulate prolactin release under the influenc… Show more

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Cited by 15 publications
(9 citation statements)
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“…These dopaminergic agonists inhibit prolactin release but their inhibitory characteristics are very different (36). All three dopaminergic agonists have stimulatory as well as inhibitory actions on prolactin release in GH 4 ZR 7 cells, but their potencies regarding the stimulatory action are different.…”
Section: Discussionmentioning
confidence: 96%
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“…These dopaminergic agonists inhibit prolactin release but their inhibitory characteristics are very different (36). All three dopaminergic agonists have stimulatory as well as inhibitory actions on prolactin release in GH 4 ZR 7 cells, but their potencies regarding the stimulatory action are different.…”
Section: Discussionmentioning
confidence: 96%
“…¹8 mol/l DA in primary cultured rat pituitary cells (36), but it is inhibited by about 10 ¹4 mol/l DA in GH 4 ZR 7 cells, indicating that GH 4 ZR 7 cells are much less sensitive to DA than primary cultured lactotrophs. The difference in the potencies is probably due to different numbers of active D 2 receptors (10).…”
Section: Prolactin Release Is Usually Inhibited By Approximately 10mentioning
confidence: 89%
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“…For instance, stress induces a PRL response, and this release of PRL is under inhibitory control of dopa mine (1)(2)(3). Furthermore, rats with a predisposition to de velop amphetamine self-administration display prolonged adrenocortical activation and increased locomotor activity after exposure to the stress of novel environment (4)(5)(6).…”
Section: R Ecent Studies Have Shown That Dopamine Is Linkedmentioning
confidence: 99%