Differential infiltration of CD8⁺and NK cells in lip and oral cavity squamous cell carcinoma

Abstract

The differential CD8+ and NK cells infiltration in oral SCC might reflect a distinctive tumor microenvironment with a favorable local cytotoxic immune response against neoplastic cells.

Histopathological grading systems and their relationship with clinical parameters in lower lip squamous cell carcinoma

“…23,27,28 In line with previous observations, Brandwein-Gensler et al 22 suggested that the lymphocytic host response to squamous cell carcinomas of the head and neck is an adaptive response mediated by cytotoxic T cells, which are found in large numbers at the interface of tumours that elicit a strong lymphocytic response (type 1).…”

Pattern of invasion in squamous cell carcinomas of the lower lip and oral cavity

“…The higher intensity of inflammation in lower lip SCCs compared to oral cavity neoplasms reported previously 24 and the downregulating effect of inflammation on ECad, 25 may help explain this finding.…”

“…Accordingly, tumors from these sites have shown considerable differences in many aspects. 23,24 Based on our results it seems that the neoplastic invasion pattern may also be considered as one of the factors that vary between these locations. The significance of this finding and its particular effect on clinical behavior of lip and oral SCCs needs to be elucidated in future studies.…”

Lymphocytic Host Response to Oral Squamous Cell Carcinoma: An Adaptive T-Cell Response at the Tumor Interface

“…T cells were associated with longer mean survival (58.2 months, 95% CI 44, 73 vs. 31.7 months, 95% CI 17, 47, Kaplan-Meier, log rank; P = 0.09) for patients with oral squamous cell carcinomas [8]. Katou demonstrated differences in the activation states between intratumoral and interface lymphocytes associated with oral squamous cell carcinoma [9].…”