Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: Mediation by the mitochondrial pathway

Altonsy, Mohammed O.; Andrews, Simon C.; Tuohy, Kieran

doi:10.1016/j.ijfoodmicro.2009.11.015

Cited by 88 publications

(42 citation statements)

References 80 publications

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“…Atopobium spp. have recently been reported as being capable of modulating caspase-9 and caspase-3 in a manner known to induce apoptosis and inhibiting Caco-2 cancer growth in vitro ( 49 ) . In addition, an increased trend in the growth of C. coccoides–E.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, most interest has focused on the potential of established prebiotics to increase the growth of bifidobacteria and lactobacilli, with little interest in the growth of other types of bacteria such as Atopobium spp., E. rectale spp. and Roseburia that may be capable of exerting anti-cancer abilities ( 49 ) . Costabile et al revealed an increase in Atopobium spp.…”

Section: Discussionmentioning

confidence: 99%

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The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation

et al. 2014

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The fruit of the date palm (Phoenix dactylifera L.) is a rich source of dietary fibre and polyphenols. We have investigated gut bacterial changes induced by the whole date fruit extract (digested date extract; DDE) and its polyphenol-rich extract (date polyphenol extract; DPE) using faecal, pH-controlled, mixed batch cultures mimicking the distal part of the human large intestine, and utilising an array of microbial group-specific 16S rRNA oligonucleotide probes. Fluorescence microscopic enumeration indicated that there was a significant increase in the growth of bifidobacteria in response to both treatments, whilst whole dates also increased bacteroides at 24 h and the total bacterial counts at later fermentation time points when compared with DPE alone. Bacterial metabolism of whole date fruit led to the production of SCFA, with acetate significantly increasing following bacterial incubation with DDE. In addition, the production of flavonoid aglycones (myricetin, luteolin, quercetin and apigenin) and the anthocyanidin petunidin in less than 1 h was also observed. Lastly, the potential of DDE, DPE and metabolites to inhibit Caco-2 cell growth was investigated, indicating that both were capable of potentially acting as antiproliferative agents in vitro, following a 48 h exposure. This potential to inhibit growth was reduced following fermentation. Together these data suggest that consumption of date fruits may enhance colon health by increasing beneficial bacterial growth and inhibiting the proliferation of colon cancer cells. This is an early suggestion that date intake by humans may aid in the maintenance of bowel health and even the reduction of colorectal cancer development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation

et al. 2014

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“…After propionate/butyrate treatment, and G0/G1 cell cycle arrest and activated caspases were induced, leading to increased apoptotic cell death [33]. Importantly, administration of L. reuteri strains was shown to alter the levels of fecal SCFAs in animals [30,31] and in fermentation systems [10]. In addition, L. reuteri bacteria haves been shown to affect the colonic fermentation of fibers and to stimulate the production profile of SCFAs [34] in simulated intestinal conditions [31].…”

Section: Discussionmentioning

confidence: 99%

“…They can release anti-carcinogenic compounds and, promote balanced bacterial growth in the colon to produce greater quantities of short chain fatty acids (SCFAs) such as acetate, propionate and butyrate, all which have anti-cancer properties [8]. Although several studies have reported the anti-proliferative or pro-apoptotic effect of probiotic bacteria on colon carcinoma cells [9][10][11], no systemic studies have been reported that screen or characterize…”

Section: Introductionmentioning

confidence: 99%

Screening and In-Vitro Analysis of Lactobacillus reuteri Strains for Short Chain Fatty Acids Production, Stability and Therapeutic Potentials in Colorectal Cancer

M¹

2015

J Bioequiv Availab

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“…It was reported that entire bacterial cells, bacterial homogenate, and cell wall extract of Lactobacillus strains could induce the apoptosis of cancer cells (Choi et al, 2006;Russo et al, 2007). Altonsy et al (2010) reported that L. rhamnosus GG and Bifidobacterium lactis Bb12 played beneficial roles in protection against colon cancer by exerting a mild apoptotic effect. The effects of the strains on the cell cycles, mitochondrial transmembrane potential, and cytochrome C of K562 cells will be further studied to explore whether the strains induced the apoptosis of the K562 cells.…”

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confidence: 99%

Short communication: Antiproliferative effect of 8 different Lactobacillus strains on K562 cells

Tuo

Jiang

Qian

et al. 2015

Journal of Dairy Science

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Some strains of Lactobacillus genus have antiproliferative activities against cancer cells. However, until now, the exact effector molecules of Lactobacillus strains with anticancer activity have not been identified. The aim of the present study was to explore which fraction of the Lactobacillus cells exerts the highest antiproliferative effect. For this purpose, the heat-killed bacterial cells, bacterial cell wall extract, and genomic DNA of 8 Lactobacillus strains were prepared to assess their antiproliferative activities against human myeloid leukemia cell lines K562. The heat-killed bacterial cells of the 8 lactobacilli strains exerted antiproliferative effect on K562 cells, and the inhibition rates exerted by the heat-killed bacterial cells of the strains G15AL, M5AL, SB31AL, SB5AL, and T3AL were significantly higher than those exerted by the cell walls and genomic DNA of the strains. The bacterial DNA of G15AL exerted higher antiproliferative effect on K562 cells. The exact effector molecules and the effect mechanism of the strains should be further explored for the application of these strains as probiotic strains or bioactive probiotic molecules.

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Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: Mediation by the mitochondrial pathway

Cited by 88 publications

References 80 publications

The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation

The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation

Screening and In-Vitro Analysis of Lactobacillus reuteri Strains for Short Chain Fatty Acids Production, Stability and Therapeutic Potentials in Colorectal Cancer

Short communication: Antiproliferative effect of 8 different Lactobacillus strains on K562 cells

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