“…However, for an effective hypersensitive response-based programmed cell death to occur, a cascade of events have to occur, including production of ROIs and associated downstream defensive responses. Indeed, increases in the activity of oxidative enzymes such as peroxidases, polyphenol oxidases and lipoxygenases were observed after Diuraphis noxia feeding ( Van der Westhuizen et al, 1998;Ni et al, 2000Ni et al, , 2001. This increase occurs not only at the site of feeding, but it also spreads systemically ( Van der Westhuizen et al 1998 (Asada, 1999).…”