Differential impairment of auditory and contextual fear conditioning by protein synthesis inhibition in C57BL/6N mice.

Stiedl, Oliver; Palve, Markki; Radulović, Jelena; Birkenfeld, Karin; Spiess, Joachim

doi:10.1037//0735-7044.113.3.496

Cited by 15 publications

(1 citation statement)

References 33 publications

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“…Drift in the resultant genetic pools has led to the Jackson substrain being referred to as C57BL/6J and the NIH substrain as C57BL/6N, which differ, in turn, from European or Asian variants of these breeding lines [42]. The C57BL/6J and C57BL/6N substrains differ in terms of their responses to sensorimotor and fear conditioning [46,47], as well as spatial memory [48]. Most of the inbred mouse strains used in brain research show differences in their stress sensitivity and anxiety [48][49][50][51], brain amine levels [52] and differences in spatial and non-spatial memory [48,53,54].…”

Section: (B) Frequency-dependency Of Homosynaptic Ltp In Hippocampal ...mentioning

confidence: 99%

Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations

Hagena,

Manahan-Vaughan

2024

Phil. Trans. R. Soc. B

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Hippocampal long-term potentiation (LTP) and long-term depression (LTD) are Hebbian forms of synaptic plasticity that are widely believed to comprise the physiological correlates of associative learning. They comprise a persistent, input-specific increase or decrease, respectively, in synaptic efficacy that, in rodents, can be followed for days and weeks in vivo . Persistent (>24 h) LTP and LTD exhibit distinct frequency-dependencies and molecular profiles in the hippocampal subfields. Moreover, causal and genetic studies in behaving rodents indicate that both LTP and LTD fulfil specific and complementary roles in the acquisition and retention of spatial memory. LTP is likely to be responsible for the generation of a record of spatial experience, which may serve as an associative schema that can be re-used to expedite or facilitate subsequent learning. In contrast, LTD may enable modification and dynamic updating of this representation, such that detailed spatial content information is included and the schema is rendered unique and distinguishable from other similar representations. Together, LTP and LTD engage in a dynamic interplay that supports the generation of complex associative memories that are resistant to generalization. This article is part of a discussion meeting issue ‘Long-term potentiation: 50 years on’.

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Section: (B) Frequency-dependency Of Homosynaptic Ltp In Hippocampal ...mentioning

confidence: 99%

Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations

Hagena,

Manahan-Vaughan

2024

Phil. Trans. R. Soc. B

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Fear memory and the amygdala: insights from a molecular perspective

Stork

Pape

2002

Cell and Tissue Research

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The amygdala modulates memory consolidation and the storage of emotionally relevant information in other brain areas, and itself comprises a site of neural plasticity during aversive learning. These processes have been intensively studied in Pavlovian fear conditioning, a leading aversive learning paradigm that is dependent on the structural and functional integrity of the amygdala. The rapidness and persistence, and the relative ease, with which this conditioning paradigm can be applied to a great variety of species have made it an attractive model for neurochemical and electrophysiological investigations on memory formation. In this review we summarise recent studies which have begun to unravel cellular processes in the amygdala that are critical for the formation of long-term fear memory and have identified molecular factors and mechanisms of neural plasticity in this brain area.

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Methamphetamine-disrupted sensory processing mediates conditioned place preference performance

Cherng

Tsai

et al. 2007

Behavioural Brain Research

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Differential impairment of auditory and contextual fear conditioning by protein synthesis inhibition in C57BL/6N mice.

Cited by 15 publications

References 33 publications

Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations

Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations

Fear memory and the amygdala: insights from a molecular perspective

Methamphetamine-disrupted sensory processing mediates conditioned place preference performance

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