Differential Impact of Periodontal Treatment Strategies During Pregnancy on Perinatal Outcomes: A Systematic Review and Meta-Analysis

Le, Quynh-Anh; Eslick, Guy D.; Coulton, Kimberly Mathieu; Akhter, Rahena; Lain, Samantha J.; Nassar, Natasha; Yaacoub, Albert; Condous, G.; Leonardi, Mathew; Eberhard, Jörg; Nanan, Ralph

doi:10.1016/j.jebdp.2021.101666

Cited by 6 publications

(9 citation statements)

References 42 publications

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“…The SRs analyzed in this study spanned from 2003 to 2023 and were conducted in various countries, including Saudi Arabia [ 43 ], the United Kingdom [ 21 , 44 ], the United States [ 45 , 46 , 47 , 48 , 49 ], Vietnam [ 50 ], Canada [ 51 , 52 ], Australia [ 53 , 54 ], India [ 55 , 56 ], Brazil [ 10 , 57 , 58 , 59 , 60 ], Germany [ 61 ], Italy [ 62 ], and Greece [ 63 , 64 ]. Additional details regarding the characteristics of these SRs can be found in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review

Arbildo-Vega,

Padilla-Cáceres,

Caballero-Apaza

et al. 2024

Medicina

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Background: The aim of this review was to evaluate the effects of periodontal disease (PD) treatment in pregnant women to reduce the risk of preterm birth (PB) and low birth weight (LBW) by conducting an umbrella review. Methods: A comprehensive search for the literature up to April 2024 was conducted across multiple databases including PubMed, Cochrane Library, Scopus, EMBASE, Scielo, Web of Science, Google Scholar, Proquest Dissertations and Theses, and OpenGrey. We specifically targeted systematic reviews (SRs) with or without meta-analyses, irrespective of language or time constraints, focusing on primary studies examining the effect of PD treatment in pregnant women to reduce the risk of PB and LBW. Various types of non-systematic reviews, intervention studies, observational studies, preclinical and basic research, summaries, comments, case reports, protocols, personal opinions, letters, and posters were excluded from consideration. The quality and overall confidence of the included studies were assessed using the AMSTAR–2 tool. Results: After the initial search, 232 articles were identified, of which only 24 met the selection criteria after exclusion. The majority of these studies indicated that periodontal treatment reduces the risk of PB and LBW. Conclusions: According to the findings and conclusions drawn from the SRs with a high overall confidence level, PD treatment in pregnant women reduces the risk of PB and LBW.

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Section: Resultsmentioning

confidence: 99%

Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review

Arbildo-Vega,

Padilla-Cáceres,

Caballero-Apaza

et al. 2024

Medicina

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“…Several studies relate periodontal disease with adverse effects during pregnancy ( 16 , 17 ) as well as the influence of saliva pH in mouth health maintenance ( 6 ); hence the importance of the study of possible relationships between these factors.…”

Section: Discussionmentioning

confidence: 99%

“…These complications must be treated opportunely to avoid progress or development of more severe forms of the disease. In pregnant women, these conditions could become a risk factor leading to premature birth, low weight of newborn, and preeclampsia ( 16 , 17 ).…”

Section: Discussionmentioning

confidence: 99%

Periodontal index and salivary Ph in first trimester´s pregnant women: A cross-sectional study

Lozano,

Asmat-Abanto

2024

J Clin Exp Dent

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Background Recent reviews have suggested a possible association between periodontal disease and increasing risks during pregnancy, such as newborn low weight, premature birth, gestational diabetes mellitus and preeclampsia. Besides, being saliva a valuable source of information on general and buccal health, it is necessary to know its parameters associated with periodontal diseases; in order to help odontologists to better understand this disease, and provide a sound clinical treatment. Therefore, this research sought to assess the correlation between periodontal index, and salivary pH on first trimester pregnant women. Material and Methods 71 pregnant women were evaluated by observational, transversal and correlational study, using the community periodontal index and salivary pH-meter. The Spearman coefficient was employed, considering a p value of 0.05. Results A correlation was found between periodontal index and salivary pH in first trimester pregnant women ( p =0.039). According to age, correlations were found to be very weak in age group 18 to 24 years ( p =0.605), and age group 25 to 35 years ( p =0.071). Similarly, no strong correlation was found when pairing based on number of pregnancies (primiparous p =0.239 and multi pregnancy p =0.114). Also, 36.6% of pregnant women showed periodontal pockets smaller than 5 mm. Conclusions With lower salivary pH, the periodontal index in pregnant women gets lower; however, no correlation could be found between age group and number of pregnancies. Key words: Periodontal index, periodontal pocket, periodontal diseases, saliva, pregnancy, pregnant women.

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“…[59][60][61] The type of periodontal treatment and its timing during pregnancy may be critical in its effect on individual pregnancy outcomes. 62 Collectively, current evidence supports that periodontal disease, especially severe forms during pregnancy, is an independent risk factor for adverse pregnancy outcomes, with timely periodontal therapy potentially useful in mitigating its deleterious effect. Additional data from future observational studies (with a temporal study design) and/or clinical trials (showing positive treatment benefits) are needed to investigate potential causal relationship.…”

Section: Periodontal Disease and Adverse Pregnancy Outcomesmentioning

confidence: 98%

Periodontal disease and systemic health: An update for medical practitioners

Kalhan

Wong

Allen

et al. 2022

Ann Acad Med Singap

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Introduction: Chronic periodontal disease is a highly prevalent dental condition affecting tooth-supporting tissues. Scientific evidence is accumulating on links between periodontal disease and various systemic conditions. This narrative review provides a holistic yet succinct overview that would assist medical practitioners to deliver integrated care for better clinical outcomes. Method: Scientific evidence on associations between periodontal disease and systemic conditions was synthesised and critically appraised. Key findings of latest prospective cohort studies, randomised clinical trials, and meta-analysis were closely assessed and compiled. Results: A bidirectional relationship has been established, indicating that diabetes and periodontal disease are closely linked and amplify one another, if not successfully controlled. Existing evidence also supports the associations of periodontal disease with cardiovascular diseases and adverse pregnancy outcomes. Successful treatment of periodontal disease and dental prophylaxis has been shown to improve clinical outcomes in these systemic conditions. Other systemic conditions associated with periodontal disease include respiratory diseases, Alzheimer’s disease, rheumatoid arthritis and chronic kidney disease. Although the underlying mechanisms remain to be fully elucidated, it is generally accepted that the inflammatory burden of chronic periodontal disease has an important systemic impact. Conclusion: Oral-systemic links are multifaceted and complex. While evidence linking periodontal disease with a variety of systemic conditions is still emerging, the nature of the relationship is becoming clearer. The updated understanding of these associations warrants the attention of medical experts and policymakers for a concerted effort to develop a patient-centric, integrated model for the treatment of comorbid dental and medical conditions. Keywords: Cardiovascular diseases, dentistry, diabetes, oral health, periodontal diseases, systemic diseases

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Differential Impact of Periodontal Treatment Strategies During Pregnancy on Perinatal Outcomes: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 42 publications

Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review

Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review

Periodontal index and salivary Ph in first trimester´s pregnant women: A cross-sectional study

Periodontal disease and systemic health: An update for medical practitioners

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