Differential impact of local and regional aortic stiffness on left ventricular remodeling

Quinaglia, Thiago; Bensalah, M.; Bollache, Emilie; Kachenoura, Nadjia; Soulat, Gilles; Boutouyrie, Pierre; Laurent, Stéphane; Mousseaux, Élie

doi:10.1097/hjh.0000000000001597

Cited by 15 publications

(11 citation statements)

References 51 publications

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“…Many longitudinal studies show regional PWV as an independent risk factor of fatal and non-fatal cardiovascular outcomes in populations with conditions such as hypertension, diabetes, and end-stage renal disease [7][8][9]. Although proven to have predictive value, carotid-femoral PWV averages the heterogeneous stiffness properties of arteries effected by aging and disease [10,11]. In addition, the carotid-femoral region contains both muscular and elastic arteries which stiffen due to different mechanisms and may be associated with different cardiovascular outcomes [3,12].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Validation of 4D Flow MRI for Local Pulse Wave Velocity Estimation

Ruesink

Medero

Rutkowski

et al. 2018

Cardiovasc Eng Tech

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4D Flow MRI is a feasible method for estimating local PWV in simple in vitro models and is a viable tool for clinical analysis. In addition, choice in transit-time algorithm depends on flow waveform shape and arterial region. This study strengthens the validity of 4D Flow MRI local PWV measurement in simple models. However, this technique requires validation in more complex models before it is used in vivo.

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Section: Introductionmentioning

confidence: 99%

In Vitro Validation of 4D Flow MRI for Local Pulse Wave Velocity Estimation

Ruesink

Medero

Rutkowski

et al. 2018

Cardiovasc Eng Tech

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“… 34 – 36 In addition, it excludes the ascending aorta from its measurement, with this playing a greater role in left ventricular remodeling compared with the rest of the aorta. 37 By its direct assessment of central aortic PWV, the current study provides valuable insights into the interaction between central aortic stiffness and left ventricular remodeling. The underlying cause of the increased systemic arterial stiffness in COPD is still a topic of debate.…”

Section: Discussionmentioning

confidence: 99%

Disconnection of pulmonary and systemic arterial stiffness in COPD

Weir‐McCall¹,

Struthers²,

Lipworth³

et al. 2018

COPD

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BackgroundBoth pulmonary arterial stiffening and systemic arterial stiffening have been described in COPD. The aim of the current study was to assess pulse wave velocity (PWV) within these two arterial beds to determine whether they are separate or linked processes.Materials and methodsIn total, 58 participants with COPD and 21 healthy volunteers (HVs) underwent cardiac magnetic resonance imaging (MRI) and were tested with a panel of relevant biomarkers. Cardiac MRI was used to quantify ventricular mass, volumes, and pulmonary (pulse wave velocity [pPWV] and systemic pulse wave velocity [sPWV]).ResultsThose with COPD had higher pPWV (COPD: 2.62 vs HV: 1.78 ms−1, p=0.006), higher right ventricular mass/volume ratio (RVMVR; COPD: 0.29 vs HV: 0.25 g/mL, p=0.012), higher left ventricular mass/volume ratio (LVMVR; COPD: 0.78 vs HV: 0.70 g/mL, p=0.009), and a trend toward a higher sPWV (COPD: 8.7 vs HV: 7.4 ms−1, p=0.06). Multiple biomarkers were elevated: interleukin-6 (COPD: 1.38 vs HV: 0.58 pg/mL, p=0.02), high-sensitivity C-reactive protein (COPD: 6.42 vs HV: 2.49 mg/L, p=0.002), surfactant protein D (COPD: 16.9 vs HV: 9.13 ng/mL, p=0.001), N-terminal pro-brain natriuretic peptide (COPD: 603 vs HV: 198 pg/mL, p=0.001), and high-sensitivity troponin I (COPD: 2.27 vs HV: 0.92 pg/mL, p<0.001). There was a significant relationship between sPWV and LVMVR (p=0.01) but not pPWV (p=0.97) nor between pPWV and RVMVR (p=0.27).ConclusionPulmonary arterial stiffening and systemic arterial stiffening appear to be disconnected and should therefore be considered independent processes in COPD. Further work is warranted to determine whether both these cause an increased morbidity and mortality and whether both can be targeted by similar pharmacological therapy or whether different strategies are required for each.

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“…The utilization of MRI techniques to quantify aortic PWV has the ability to quantify changes at a local level, producing an accurate patient-specific spatial map of PVW. A study by Quinaglia [81] reported PWV readings targeted to the ascending aorta and found velocities of between 4 and 5.8 m/s, while [82] investigated the brachio-femoral pathway in 152 young adults and found mean PWV values of 8.7 m/s. Such measurements are comparable with the data presented in the current study for the thoracic and abdominal aorta respectively.…”

Section: Spatial Haemodynamicsmentioning

confidence: 99%

A Dual-VENC Four-Dimensional Flow MRI Framework for Analysis of Subject-Specific Heterogeneous Nonlinear Vessel Deformation

Concannon

Hynes

McMullen

et al. 2020

Journal of Biomechanical Engineering

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Advancement of subject-specific in-silico medicine requires new imaging protocols tailored to specific anatomical features, paired with new constitutive model development based on structure/function relationships. In this study we develop a new dual-VENC 4D Flow MRI protocol that provides unprecedented spatial and temporal resolution of in-vivo aortic deformation. All previous dual-VENC 4D Flow MRI studies in the literature focus on an isolated segment of the aorta, which fail to capture the full spectrum of aortic heterogeneity that exists along the vessel length. The imaging protocol developed provides high sensitivity to all blood flow velocities throughout the entire cardiac cycle, overcoming the challenge of accurately measuring the highly unsteady non-uniform flow field in the aorta. Cross sectional area change, volumetric flow rate, and compliance are observed to decrease with distance from the heart, while pulse wave velocity is observed to increase. A non-linear aortic lumen pressure-area relationship is observed throughout the aorta, such that a high vessel compliance occurs during diastole, and a low vessel compliance occurs during systole. This clearly demonstrates that vessel compliance during a cardiac cycle cannot be simplistically represented by a single value. This high-resolution MRI data provides key information on the spatial variation in non-linear aortic compliance which can significantly advance the state-of-the-art of in-silico diagnostic techniques for the human aorta.

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Differential impact of local and regional aortic stiffness on left ventricular remodeling

Cited by 15 publications

References 51 publications

In Vitro Validation of 4D Flow MRI for Local Pulse Wave Velocity Estimation

In Vitro Validation of 4D Flow MRI for Local Pulse Wave Velocity Estimation

Disconnection of pulmonary and systemic arterial stiffness in COPD

A Dual-VENC Four-Dimensional Flow MRI Framework for Analysis of Subject-Specific Heterogeneous Nonlinear Vessel Deformation

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