Differential immunologic effects of language-dominant and nondominant cerebral resections

Meador, Kimford J.; Lecuona, J. M. De; Helman, Sandra W.; Loring, David W.

doi:10.1212/wnl.52.6.1183

Cited by 20 publications

(12 citation statements)

References 31 publications

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“…One small study showed a decreased immunological function and greater risk of infection in stroke subjects with left-sided cerebral lesions [40], postulating the existence of a lateralization of the immunomodulation after stroke. However, experimental studies [41] and patients with brain tumors, or stroke, have provided conflicting results [42][43][44]. Our results confirmed that larger lesions conveyed a greater risk of infection [25], but found that the risk was not related to the topography of the infarction.…”

Section: Discussionsupporting

confidence: 73%

Catecholamines, infection, and death in acute ischemic stroke

Chamorro

Vargas

Obach

et al. 2007

Journal of the Neurological Sciences

173

135

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Section: Discussionsupporting

confidence: 73%

Catecholamines, infection, and death in acute ischemic stroke

Chamorro

Vargas

Obach

et al. 2007

Journal of the Neurological Sciences

173

135

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“…17,18 In a pilot study of epilepsy surgery patients, we found that left resections reduced lymphocytes and T cells in the early postoperative period, whereas right resections increased the same cellular elements. 19 In this study, we sought to replicate these findings in a new cohort and extend observations in time and parameters. We examined effects of cerebral lateralization and brain resections on the following immune measures: (1) nonspecific responses including in vivo cellular components (ie, leukocytes, total lymphocytes, total T cells, T helper, T cytotoxic, B cells, and NK cells), in vitro cellular mitogen responses (ie, concanavalin A, phytohemaglutin, and pokeweed), and in vivo noncellular responses (ie, wheal and flare histamine skin responses); and (2) specific in vitro responses to microbial antigens (ie, Tetanus and Candida).…”

mentioning

confidence: 86%

Role of cerebral lateralization in control of immune processes in humans

Meador

Loring

Ray

et al. 2004

Annals of Neurology

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Cerebral lateralization may be important in neural control of immune function. Animal studies have demonstrated differential effects of left and right brain lesions on immune function, but human studies are inconclusive. Here, we show that resections in the language dominant hemisphere of patients with epilepsy reduce lymphocytes, total T cells, and helper T cells. In contrast, resections in the language nondominant hemisphere increased the same cellular elements. T-cell responses to mitogens and microbial antigens were not differentially affected. Left/right arm histamine skin response ratios were altered in patients with left cerebral epileptic focus, and flare skin responses were reduced by left cerebral resections in contrast with an increase after right cerebral resections. The findings demonstrate a differential role of the left and right cerebral hemispheres on immune functions in humans.

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“…Gruzelier et al [19] reported a significant positive correlation between higher left-sided activation (lower EEG amplitude) and CD8+ T-lymphocytes count, and, conversely, relatively higher right-sided activation associated with lower CD8+ count. Meador et al [20] compared postoperative to preoperative T-lymphocyte indices in epileptic patients who had undergone neurosurgical treatment. The researchers found that the absolute lymphocyte count, total T-cells (CD3+), helper T-cells (CD3+4+), cytotoxic/suppressor cells (CD3+8+), and total suppressor cells (CD8+) were reduced following surgical interventions on the language-dominant hemisphere, however, they increased after non-dominant hemisphere resections.…”

Section: Hemispheric Lateralization In Neuroimmunomodulationmentioning

confidence: 99%

Brain asymmetry, immunity, handedness

et al. 2011

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AbstractThe principle of symmetry-asymmetry is widely presented in the structural and functional organization of the nonliving and living nature. One of the most complex manifestations of this principle is the left-right asymmetry of the human brain. The present review summarizes previous and contemporary literary data regarding the role of brain asymmetry in neuroimmunomodulation. Some handedness-related peculiarities are outlined additionally. Brain asymmetry is considered to be imprinted in the formation and regulation of the individual’s responses and relationships at an immunological level with the external and internal environment. The assumptions that the hemispheres modulate immune response in an asymmetric manner have been confirmed in experiments on animals. Some authors assume that the right hemisphere plays an indirect role in neuroimmunomodulation, controlling and suppressing the left hemispheric inductive signals.

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Differential immunologic effects of language-dominant and nondominant cerebral resections

Cited by 20 publications

References 31 publications

Catecholamines, infection, and death in acute ischemic stroke

Catecholamines, infection, and death in acute ischemic stroke

Role of cerebral lateralization in control of immune processes in humans

Brain asymmetry, immunity, handedness

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