Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas

Alkonyi, Bálint; Nowak, Johannes; Gnekow, Astrid; Pietsch, Torsten; Warmuth‐Metz, Monika

doi:10.1007/s00234-015-1498-4

Cited by 41 publications

(36 citation statements)

References 59 publications

(96 reference statements)

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“…7 A further concern is the nonlinear correlation between contrast enhancement and tumor grade in children, in which grade I tumors (pilocytic astrocytomas) can show vivid enhancement despite the low tumor grade. 8,9 As an alternative to contrast-enhanced MR perfusion, arterial spin-labeling (ASL) is based on magnetic labeling of water molecules as an endogenous contrast agent. ASL, which provides absolute estimates of CBF, has been proved a valuable tool for adult patients with brain tumors for discriminating LGT and HGT.…”

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confidence: 99%

Arterial Spin-Labeling in Children with Brain Tumor: A Meta-Analysis

Delgado

Luca

Hanagandi

et al. 2018

AJNR Am J Neuroradiol

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confidence: 99%

Arterial Spin-Labeling in Children with Brain Tumor: A Meta-Analysis

Delgado

Luca

Hanagandi

et al. 2018

AJNR Am J Neuroradiol

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“…1,2,5,7 Imaging findings describe PMA as a well-circumscribed lesion, with solid and cystic components, often located on the hypothalamus. 2,3,8 The lesions are generally isointense on T1-weighted MRI images and hyperintense on T2-weighted ones. 2,8 Evidence of necrosis is rare and occasionally signs of hydrocephalus, mass effect and peritumoral edema may be seen.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,8 The lesions are generally isointense on T1-weighted MRI images and hyperintense on T2-weighted ones. 2,8 Evidence of necrosis is rare and occasionally signs of hydrocephalus, mass effect and peritumoral edema may be seen. 2,3,8 Several of these characteristics are shared with PA findings and therefore, there are no radiographic features that can reliably distinguish these two entities.…”

Section: Discussionmentioning

confidence: 99%

“…2,8 Evidence of necrosis is rare and occasionally signs of hydrocephalus, mass effect and peritumoral edema may be seen. 2,3,8 Several of these characteristics are shared with PA findings and therefore, there are no radiographic features that can reliably distinguish these two entities. 2,8 Though recently PMA has been further studied, its behavior is still a matter of debate.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,8 Several of these characteristics are shared with PA findings and therefore, there are no radiographic features that can reliably distinguish these two entities. 2,8 Though recently PMA has been further studied, its behavior is still a matter of debate. The previous World Health Organization (WHO) classification for tumors of the central nervous system classified the PMA as a grade II tumor, while PA is reported as grade I.…”

Section: Discussionmentioning

confidence: 99%

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Pilomyxoid Astrocytoma: Case Report

2018

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The pilomyxoid astrocytoma (PMA) is a rare glioma recently described as a separate entity, which is generally located on the hypothalamic area. The PMA was previously described as pilocytic astrocytoma (PA) due to similarities shared between them. Recent studies provided a deeper understanding of PMA, setting it as a separate entity, though PMA is still considered by many authors a variant of PA. The PMA is considered to be more aggressive than PA; however, further studies are necessary for a better comprehension of its behavior and, hence, for neurosurgeons and neurologists to get to a consensus about its management.This study presents a 16-year-old female patient who looked for medical assistance complaining of headaches of over 6 months and vomiting for 2 weeks prior to the visit to the doctor. She presented no other symptoms. The physical examination displayed only bilateral papilledema. The magnetic resonance imaging (MRI) scans showed an intraventricular and thalamic lesion composed of solid and cystic material associated with peritumoral edema. The patient underwent ventriculoperitoneal shunt and subtotal resection of the lesion. The histological and immunohistochemical studies showed typical features of PMA. The patient started adjuvant therapy with chemotherapy and radiosurgery. She has been asymptomatic for 9 months and has shown no signs of progression of the disease on the follow-up scans.

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