Differential gene expression in the rat cochlea after exposure to impulse noise

Distribution of NTPDase5 and NTPDase6 and the regulation of P2Y receptor signalling in the rat cochlea

“…Increased NTPDase5 and P2Y 6 expression in the SGN is consistent with an upregulation of other components of the purinergic signalling system with noise [5,9,10]. In addition, loud sound induces an inflammatory response in the cochlea with the infiltration of inflammatory cells and an increase in the expression of a variety of genes involved in inflammatory responses [47,48]. UDP is a pro-inflammatory signal [49], and its release from damaged neurons may promote the macrophage migration into the cochlea.…”

Identification of new altered genes in rat cochleae with noise-induced hearing loss

“…However, the loss of hair cells in humans is permanent because the auditory cells are considered terminally differentiated cells that lack the ability to regenerate (Matsui and Cotanche, 2004;Oshima et al, 2007). Noise-induced deafness is believed to be irreversible (Kirkegaard et al, 2006). As previously reported, excessive noise might induce changes in gene expression.…”

“…These genes belong to several apoptotic gene families and participate in multiple signalling pathways that mediate cell survival or cell death (Hu et al, 2009). Kirkegaard et al (2006) have reported a significant early up-regulation of inflammatory response genes and genes that are involved in cellular antioxidant defence in the cochleae of rats after impulse noise exposure, which results in hair cell apoptosis and deafness. Cho et al (2004) have demonstrated that several immediate early genes encoding transcription factors and cytokines are induced 3 h after intense noise exposure that resulted in permanent hearing loss.…”

High throughput gene expression analysis of the inner ear

“…Differential gene expression has also been measured in rats in response to noise injury (Kirkegaard et al, 2006), hypoxia (Gross et al, 2009), deafferentation (Horii et al, 2004) and hypergravity (Iijima et al, 2004). Inhibition of NF-kappaB leads to apoptotic cell death in the cochlea and was shown to be associated with an upregulation in the mRNA encoding the regulatory subunit of phosphatidylinositol 3-kinase (Nagy et al, 2007).…”