Abstract:The aim of the investigation was to study differential gene expression and signaling pathways activation in radioresistant and radiosensitive cancer cell lines.Materials and Methods. K562 radioresistant cancer cell line of chronic myeloleukosis, and HCT-116p53 (+/+), HCT-116p53 (-/-), Me45 radiosensitive cancer cell lines were used in the study. Transcriptome analysis was performed using Affymetrix DNA microarray HGU133A series. Original Gene Selector program was used for bioinformation analysis. Protein inter… Show more
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