Differential gene expression analysis of spatial transcriptomic experiments using spatial mixed models
Oscar E. Ospina,
Alex C. Soupir,
Roberto Manjarres-Betancur
et al.
Abstract:Spatial transcriptomics (ST) assays represent a revolution in the way the architecture of tissues is studied, by allowing for the exploration of cells in their spatial context. A common element in the analysis is the delineation of tissue domains or "niches" followed by the detection of differentially expressed genes to infer the biological identity of the tissue domains or cell types. However, many studies approach differential expression analysis by using statistical approaches often applied in the analysis … Show more
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