Differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence

Adriaens, I.

doi:10.1093/humrep/deh074

Cited by 140 publications

(123 citation statements)

References 31 publications

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“…The elevations in caspase-3 and caspase-7 activities in thecainterstitial cells were accompanied by an increase in apoptosis [50]. Furthermore, Adriaens et al [51] have shown that differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence. Although early preantral follicles are independent of FSH for their initial growth, FSH receptors are present on the GCs of these follicles [51].…”

Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

“…Furthermore, Adriaens et al [51] have shown that differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence. Although early preantral follicles are independent of FSH for their initial growth, FSH receptors are present on the GCs of these follicles [51]. The best known FSH receptor is FSHR-1 [51].…”

Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

“…Although early preantral follicles are independent of FSH for their initial growth, FSH receptors are present on the GCs of these follicles [51]. The best known FSH receptor is FSHR-1 [51]. However, several events occur well before the expression of the stimulatory G-protein-coupled FSHR-1 [51], suggesting that other FSHR motifs might function to play a role during development.…”

Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

“…The best known FSH receptor is FSHR-1 [51]. However, several events occur well before the expression of the stimulatory G-protein-coupled FSHR-1 [51], suggesting that other FSHR motifs might function to play a role during development. It was proven that a new splice variant, FSHR-3, is present in immature ovaries and that there is a positive correlation between follicle differentiation and the expression of this receptor [51,52].…”

Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

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How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries

Blumenfeld¹

2007

The Oncologist

247

181

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After completing this course, the reader will be able to:1. Discuss the possibilities for preserving fertility in women exposed to chemotherapy.2. List the possible mechanisms put forward to explain the beneficial effect of GnRH agonists in minimizing the gonadotoxic effect of chemotherapy, in particular that of alkylating agents.3. Identify the advantages and possible risks and shortcomings of each of the proposed methods for fertility preservation in women exposed to gonadotoxic chemotherapy.4. Discuss the possibility of combining several methods to maximize the chances of fertility preservation in these patients.5. Explain the gender differences between male and female patients regarding the methods of fertility preservation.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACTThe possibilities to preserve fertility in women exposed to chemotherapy are: in vitro fertilization plus embryo cryopreservation, ovarian cryopreservation, unfertilized ova cryopreservation, and the administration of a gonadotropin-releasing hormone (GnRH) agonist. Because none of these methods is ideal, combination of several methods should be considered. Because the chances of preserving gonadal function following combinedmodality treatment are significantly better for girls than for boys, simulation of a prepubertal milieu was applied only to women of reproductive age.

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Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

Section: I: Interruption Of Follicle-stimulating Hormone Secretionmentioning

confidence: 99%

See 2 more Smart Citations

How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries

Blumenfeld¹

2007

The Oncologist

247

181

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“…The capacity of the cumulus to support oocyte maturation during antral follicle growth requires two types of stimulation: stimulation of oocyte factors GDF9 and BMP15 (Lucidi et al 2003, Pangas & Matzuk 2005, and gonadotropin stimulation with FSH and/or LH (Adriaens et al 2004, Sirard et al 2007. Additionally, gonadotropin signal transduction by the somatic compartment requires de novo mRNA synthesis within CCs (Meinecke & Meinecke-Tillmann 1993).…”

Section: Introductionmentioning

confidence: 99%

Cumulus cell gene expression following the LH surge in bovine preovulatory follicles: potential early markers of oocyte competence

Assidi¹,

Dieleman²,

Sirard³

2010

Reproduction

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Cumulus cells (CCs) are essential for oocytes to reach full development competency and become fertilized. Many major functional properties of CCs are triggered by gonadotropins and governed by the oocyte. Consequently, cumulus may reflect oocyte quality and is often used for oocyte selection. The most visible function of CCs is their ability for rapid extracellular matrix expansion after the LH surge. Although unexplained, LH induces the final maturation and improves oocyte quality. To study the LH signaling and gene expression cascade patterns close to the germinal vesicle breakdown, bovine CCs collected at 2 h before and 6 h after the LH surge were hybridized to a custom-made microarray to better understand the LH genomic action and find differentially expressed genes associated with the LH-induced oocyte final maturation. Functional genomic analysis of the 141 overexpressed and 161 underexpressed clones was performed according to their molecular functions, gene networks, and cell compartments. Following real-time PCR validation of our gene lists, some interesting pathways associated with the LH genomic action on CCs and their possible roles in oocyte final maturation, ovulation, and fertilization are discussed. A list of early potential markers of oocyte competency in vivo and in vitro is thereafter suggested. These early biomarkers are a preamble to understand the LH molecular pathways that trigger the final oocyte competence acquisition process in bovine.

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Stereological Assessment of Developing Mouse Ovarian Follicles in an in vitro Culture System

Chand¹,

Legge

2011

The Anatomical Record

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The aim of this project was to validate the use of ovarian follicular diameter measurement as an indicator of growth using stereology as an independent measure. A strong linear correlation was observed between follicular volume and diameter, and between follicular volume and the total number of granulosa cells. These results have provided a useful validation of a widely used technique for determining follicular growth in vitro.

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Differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence

Abstract: Exposure to FSH before formation of the antral-like cavity had a positive effect on follicle survival and oocyte robustness.

Cited by 140 publications

References 31 publications

How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries

How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries

Cumulus cell gene expression following the LH surge in bovine preovulatory follicles: potential early markers of oocyte competence

Stereological Assessment of Developing Mouse Ovarian Follicles in an in vitro Culture System

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