Differential expression profiling of onco and tumor-suppressor genes from major-signaling pathways in Wilms’ tumor

Sahu, Dinesh Kumar; Singh, Neetu; Das, Mumani; Rawat, Jiledar; Gupta, Devendra K.

doi:10.1007/s00383-022-05202-2

Cited by 3 publications

(2 citation statements)

References 63 publications

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“…WT2 gene (Wilms' Tumor 2 gene) is located on chromosome 11p15. The abnormal regulation of chromosome 11p15.5 is related to Beckwith-Widemann syndrome (macrosomia, macroglossia, hemihypertrophy, omphalocele, visceromegaly, Wilms' tumor) [65,66]. We must note that most cases of Wilms' tumor do not exhibit mutations of the above-mentioned genes [67].…”

Section: Nephroblastoma or Wilms' Tumor (Wt)mentioning

confidence: 99%

PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis

Bădoiu

Greabu

Miricescu

et al. 2023

IJMS

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Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th place among the most frequent histological types of cancer. Clear cell renal cell carcinoma (ccRCC), accounts for 75% of RCCs and has the most kidney cancer-related deaths. One-third of the patients with ccRCC develop metastases. Renal cancer presents cellular alterations in sugars, lipids, amino acids, and nucleic acid metabolism. RCC is characterized by several metabolic dysregulations including oxygen sensing (VHL/HIF pathway), glucose transporters (GLUT 1 and GLUT 4) energy sensing, and energy nutrient sensing cascade. Metabolic reprogramming represents an important characteristic of the cancer cells to survive in nutrient and oxygen-deprived environments, to proliferate and metastasize in different body sites. The phosphoinositide 3-kinase-AKT-mammalian target of the rapamycin (PI3K/AKT/mTOR) signaling pathway is usually dysregulated in various cancer types including renal cancer. This molecular pathway is frequently correlated with tumor growth and survival. The main aim of this review is to present renal cancer types, dysregulation of PI3K/AKT/mTOR signaling pathway members, crosstalk with VHL/HIF axis, and carbohydrates, lipids, and amino acid alterations.

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Section: Nephroblastoma or Wilms' Tumor (Wt)mentioning

confidence: 99%

PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis

Bădoiu

Greabu

Miricescu

et al. 2023

IJMS

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“…FGFR3 is also downregulated in WT [ 66 ]; however, in pediatric CNS tumors, opposite FGFR3 expression profiles are observed. In NB, high expression levels are associated with worse overall survival and event-free survival (EFS) [ 67 ].…”

Section: Protein Kinases In Pediatric Oncology and Their Association ...mentioning

confidence: 99%

Drugging Hijacked Kinase Pathways in Pediatric Oncology: Opportunities and Current Scenario

et al. 2023

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Childhood cancer is considered rare, corresponding to ~3% of all malignant neoplasms in the human population. The World Health Organization (WHO) reports a universal occurrence of more than 15 cases per 100,000 inhabitants around the globe, and despite improvements in diagnosis, treatment and supportive care, one child dies of cancer every 3 min. Consequently, more efficient, selective and affordable therapeutics are still needed in order to improve outcomes and avoid long-term sequelae. Alterations in kinases’ functionality is a trademark of cancer and the concept of exploiting them as drug targets has burgeoned in academia and in the pharmaceutical industry of the 21st century. Consequently, an increasing plethora of inhibitors has emerged. In the present study, the expression patterns of a selected group of kinases (including tyrosine receptors, members of the PI3K/AKT/mTOR and MAPK pathways, coordinators of cell cycle progression, and chromosome segregation) and their correlation with clinical outcomes in pediatric solid tumors were accessed through the R2: Genomics Analysis and Visualization Platform and by a thorough search of published literature. To further illustrate the importance of kinase dysregulation in the pathophysiology of pediatric cancer, we analyzed the vulnerability of different cancer cell lines against their inhibition through the Cancer Dependency Map portal, and performed a search for kinase-targeted compounds with approval and clinical applicability through the CanSAR knowledgebase. Finally, we provide a detailed literature review of a considerable set of small molecules that mitigate kinase activity under experimental testing and clinical trials for the treatment of pediatric tumors, while discuss critical challenges that must be overcome before translation into clinical options, including the absence of compounds designed specifically for childhood tumors which often show differential mutational burdens, intrinsic and acquired resistance, lack of selectivity and adverse effects on a growing organism.

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The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies

Ren,

Lv,

Tao

et al. 2024

Front. Pharmacol.

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The CBL (Casitas B-lineage lymphoma) family, as a class of ubiquitin ligases, can regulate signal transduction and activate receptor tyrosine kinases through various tyrosine kinase-dependent pathways. There are three members of the family: c-CBL, CBL-b, and CBL-c. Numerous studies have demonstrated the important role of CBL in various cellular pathways, particularly those involved in the occurrence and progression of cancer, hematopoietic development, and regulation of T cell receptors. Therefore, the purpose of this review is to comprehensively summarize the function and regulatory role of CBL family proteins in different human tumors, as well as the progress of drug research targeting CBL family, so as to provide a broader clinical measurement strategy for the treatment of tumors.

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Differential expression profiling of onco and tumor-suppressor genes from major-signaling pathways in Wilms’ tumor

Cited by 3 publications

References 63 publications

PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis

PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis

Drugging Hijacked Kinase Pathways in Pediatric Oncology: Opportunities and Current Scenario

The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies

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