Differential expression profiles of plasma exosomal microRNAs in dilated cardiomyopathy with chronic heart failure

Abstract

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Unraveling the Signaling Dynamics of Small Extracellular Vesicles in Cardiac Diseases

“…Multiple lines of evidence have also been reported, indicating that such exosome-mediated cellular communication is altered and impaired in pathological conditions, particularly in oncogenesis [4,11]. More recently, impaired exosome signaling has also been reported in distinct cardiovascular pathological contexts, including ischemic [67][68][69], electrical [280][281][282][283][284][285][286] and structural [215,223] cardiopathies. It is important to highlight in this context that increasing evidence is reported about the functional role of exosomes in distinct ischemic diseases, such as MI and coronary artery diseases, as well as in structural heart diseases such as DCM and HCM, as reviewed in this study.…”

“…In order to find biomarkers for DCM diagnosis, Zhang et al (2023) performed isolation of exosomes in patients with chronic heart failure (CHF) caused by DCM. By next generation sequencing, they identified 92 microRNAs differentially expressed, and gene ontology analysis revealed that these microRNAs are related to oxytocin signalling, Hippo signalling and Ras signalling, pointing them out as candidates for CHF diagnosis [223]. As mentioned in previous paragraphs, diabetes mellitus is related with complications in HF with preserved ejection fraction (HFpEF).…”

“…Zhang et al (2023) [223] performed high-throughput sequencing in plasma exosomes of DCM patients with chronic heart failure (CHF) and healthy controls, and a total of 3687 miRNAs were detected in these biological samples. However, only 92 miR-NAs were significantly differentially expressed between the two groups; 48 miRNAs were upregulated and 44 miRNAs were downregulated [223].…”

“…Zhang et al (2023) [223] performed high-throughput sequencing in plasma exosomes of DCM patients with chronic heart failure (CHF) and healthy controls, and a total of 3687 miRNAs were detected in these biological samples. However, only 92 miR-NAs were significantly differentially expressed between the two groups; 48 miRNAs were upregulated and 44 miRNAs were downregulated [223]. Six of these miRNAs have been identified as significant contributors to the development of DCM through diverse mechanisms, such as the regulation of fibrosis (miR-423-5p, hsa-miR-185-5p, hsa-miR-150-5p, hsa-miR-10a-5p_R-1) [228][229][230][231][232][233], hypertrophy (hsa-miR-150-5p) [231,232], inflammation (hsa-miR-1304-3p_1ss13CA, hsa-miR-150-5p) [231,232,234], oxidative stress (hsa-miR-1304-3p_1ss13CA) [234], angiogenesis (hsa-miR-150-5p) [235] and mitochondrial function (sa-miR-3138_L-5R+2) [236] (Table 3).…”

An assessment system for clinical and biological interpretability in ulcerative colitis

“…A variety of disease activity indexes are established according to the results of clinical, laboratory, and endoscopic examinations, but they are mainly used in clinical trials [ 29 ]. The construction of biomarkers with fewer genes means lower cost and easier access to clinical applications [ 30 , 31 ]. In the time of advocating individualized treatment, it is imperative to determine non-invasive biomarkers to monitor normal people for accurate diagnosis and prevention of UC, so as to optimize the early diagnosis and drug treatment of UC.…”