Differential expression profiles of miRNA in the serum of sarcopenic rats

Yu, Wonjong; Yang, Min-Kyu; Sung, Dong Jun; Park, Tae Jun; Kim, Myungchul; Ntigura, Eustache; Kim, Sung Hoon; Park, Sang Woong; Bae, Young Min

doi:10.1016/j.bbrep.2022.101251

Cited by 1 publication

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These genes are related to muscle degeneration and are inhibited by miR‐133; therefore, downregulation of this miRNA results in muscle degeneration (Giakoumaki et al, 2022). On the other hand, different subtypes of miR‐133, including miR‐133b‐3p, miR‐133a‐3p and miR‐133c are upregulated in the serum of sarcopenic male Sprague‐Dawley rats (W. Yu, Yang, et al, 2022). Expression of miR‐133a is also upregulated in C57BL/6 mice and mice C2C12 cell line (Soriano‐Arroquia, House, et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…This miRNA expedites FOXO3 nuclear localization, which is an atrophy inducing transcription factor; therefore, upregulation of miR‐21 reduces muscle viability and promotes muscle atrophy (Borja‐Gonzalez et al, 2020). Also, in another expression analysis of sarcopenic male Sprague‐Dawley rats, upregulation of miR‐21‐3p was approved (W. Yu, Yang, et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sarcopenia and noncoding RNAs: A comprehensive review

Ghafouri‐Fard

Askari

Hussen

et al. 2023

Journal Cellular Physiology

View full text Add to dashboard Cite

Sarcopenia is an elderly disease and is related to frailty and loss of muscle mass (atrophy) of older adults. The exact molecular mechanisms contributing to the pathogenesis of disease are yet to be discovered. In recent years, the role of noncoding RNAs in the pathogenesis of almost every kind of malignant and nonmalignant conditions is pinpointed. Regarding their regulatory function, there have been an increased number of studies on the role of noncoding RNAs in the progress of sarcopenia. In this manuscript, we review the role of microRNAs and long noncoding RNAs in development and progression of disease. We also discuss their potential as therapeutic targets in this condition.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%