Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men

Abstract

Serine/threonine kinase 33 (STK33/Stk33) is a recently discovered gene whose inferred amino acid sequence translation displays characters typical for a calcium/calmodulin dependent kinase (CAMK). In this study we analysed the STK33/Stk33 RNA and protein distribution and the localization of the protein. The STK33/Stk33 expression pattern resembles those of some related members of the CAMK group. STK33/Stk33 displays a nonubiquitous and, in most tissues, low level of expression. It is highly expressed in testis, particularly in cells from the spermatogenic epithelia. Moreover, significant expression is detected in lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. A possible role of STK33/Stk33 in spermatogenesis and organ ontogenesis is discussed.

STK33 alleviates gentamicin‐induced ototoxicity in cochlear hair cells and House Ear Institute‐Organ of Corti 1 cells

“…Serine/threonine kinase 33 (STK33) gene, which is identified in human chromosome 11 and mouse chromosome 7, encodes a serine/threonine kinase . STK33 belongs to a member of the calcium/calmodulin‐dependent kinase (CAMK), which is mainly existed in testis, certain brain regions and embryonic organs such as brain, heart and spinal cord in human and mouse and is likely to participate in spermatogenesis and organ ontogenesis .…”

STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential

“…The results from these studies revealed that STK33 expression is limited, with low expression in most tissues. However, STK33 is highly expressed in testis, particularly in the spermatogenic epithelium [2]. Based on a sequence comparison with other kinases, the STK33/ Stk33 protein was classified as a member of the Ca 2+ /calmodulindependent kinase family [3].…”

“…The human serine/threonine kinase 33 (STK33) gene (called stk33 in mouse) is located on chromosome 11, region 11p15.3, and includes 12 introns and a 1545 bp open-reading frame; while the stk33 gene is found on chromosome 7 in mouse [1,2]. Researchers have analyzed STK33 mRNA and protein expression in many normal human adult and embryonic tissues to investigate the distribution and location of STK33.…”

Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)

“…27 In addition, STK33 has been identified as a synthetic lethal in KRAS mutant lung cancers. 28,29 TTK (D697Y) (also known as MPS1) is a dual specificity kinase (Tyr and Ser/Thr) associated with proliferation through training set.…”