Differential Expression of α3 Fucosyltransferases in Th1 and Th2 Cells Correlates with Their Ability to Bind P-Selectin

A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells

“…It is well established that Th1 cells express high levels of selectin ligands, whereas naive CD4 cells express no detectable selectin ligands, and Th2 cells, at least in vitro, express low levels. [2][3][4] This pattern of expression of selectin ligands parallels closely the expression of fucosyltransferase VII (FucT-VII), a key glycosyltransferase that is essential for the formation of selectin ligands, particularly in T lymphocytes. 3,5,6 Recent work indicates that induction of FucT-VII is controlled primarily via the T-cell receptor (TCR) by strong Harvey-ras (H-Ras) signaling, 7,8 consistent with the association between strong TCR signaling and Th1 cell fate.…”

AChlamydia trachomatis-Specific Th2 Clone Does Not Provide Protection against a Genital Infection and Displays Reduced Trafficking to the Infected Genital Mucosa

“…Recently, it has been shown that differences in the abilities of Th1 and Th2 cells to bind to CD62P and CD62E resulted in migration differences in vivo (2). Although P-selectin ligand 1 (PSGL-1) is expressed on both subsets of T cells (4), binding to CD62P requires posttranslational glycoslylation of PSGL-1, which occurs in Th1 cells (45). T cells also bind to CD62E via PSGL-1, and CD62E-binding T cells are a subset of T cells that also bind CD62P (10,12).…”

“…Also, the two clones expressed similar levels of adhesion molecules ␣4, ␤1, and CD11a. Thus, differences in the abilities of Th1-MoPn and Th2-MoPn to migrate to the GT may, in part, be due to reduced expression of PSGL-1 and LPAM-1 (2,11,44,45).…”

The effects of nitric oxide on the immune system during Trypanosoma cruzi infection

“…Of note, inactivation of P-selectin expression by NO, which affects leukocyte adherence, may also preferentially affect Th1 cell migration (van Wely et al 1998).…”