Differential expression of VEGF ligands and receptors in prostate cancer

Woollard, David John; Opeskin, Kenneth; Coso, Sanja; Wu, Di; Baldwin, Megan E.; Williams, Elizabeth D.

doi:10.1002/pros.22596

Cited by 33 publications

(32 citation statements)

References 41 publications

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“…VEGF is the major angiogenic cytokine mediator; therefore, it is crucial for tumor development and metastasis [8]. In addition to macrophages and cancer infiltrating T cells [19], VEGF is expressed by several human solid tumors including PCa [20][21][22][23][24][25][26][27]. VEGF over-expression in prostate tumors has been correlated with increased tumor microvessel density [28], disease progression, lymph node metastasis, resistance to treatment, and poor survival [10].…”

Section: Discussionmentioning

confidence: 99%

Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

Martínez‐Fierro

Garza‐Veloz

Rojas-Martínez

et al. 2013

CBM

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Section: Discussionmentioning

confidence: 99%

Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

Martínez‐Fierro

Garza‐Veloz

Rojas-Martínez

et al. 2013

CBM

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“…VEGF expression has an important impact on overall survival in patients with osteosarcoma and high VEGF expression is associated with poorer overall survival [37,38]. Activation of VEGFR-1 by VEGF-A within the carcinoma, and activation of lymphatic endothelial cell VEGFR-3 by VEGF-D within the adjacent benign stroma may be important signaling mechanisms involved in the progression and subsequent metastatic spread of prostate cancer [39]. Alterations in the expression of VEGF and VEGF receptors are associated with disease stage and recurrence in bladder cancer patients [40].…”

Section: Non-digestive Cancersmentioning

confidence: 99%

VEGF expression in pancreatic cancer and other malignancies: a review of the literature

Costache

Ioana

Iordache

et al. 2015

Romanian Journal of Internal Medicine

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Angiogenesis is a crucial event for tumor growth and it is regulated predominantly by several different growth factors. Vascular endothelial growth factor protein family (VEGF) and its receptors are probably the most important tissue factors responsible for angioblast differentiation and tube formation. VEGF protein family currently comprises several members: VEGF (or VEGF-A), VEGF-B, VEGF-C and VEGF-D, VEGF-F, placental growth factor (PlGF), and their receptors VEGFR-1, VEGFR-2 and VEGFR-3. VEGF is a key angiogenic growth factor and its level of expression is a critical marker for detection of the angiogenic diseases. The potent role of VEGF in tumor angiogenesis has been widely described in the past decade, being expressed in most types of nondigestive and digestive cancers. VEGF family members play an important role in the development of pancreatic cancer (especially VEGF-A, VEGF-C, VEGF-D, VEGFR-1 and VEGFR-2). VEGF-A is the most specific and prominent angiogenic factor among all family members and VEGFR-2 is the most important receptor in evaluating the angiogenesis in pancreatic cancer. Thus, VEGF overexpression may be considered as a diagnostic marker and as a poor prognostic factor of the disease.

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“…Pelvic lymph node involvement is the first indication of metastasis in the majority of cases of PCa, followed by transfers to other organs, including bones, lungs and liver (9). The metastasis of PCa to regional lymph nodes is a frequent early event that is associated with poor clinical treatment (10). Aurora kinase A is overexpressed in metastatic PCa and is associated with tumor development and progression (11).…”

Section: Introductionmentioning

confidence: 99%

Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis

et al. 2017

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Abstract. To screen for marker genes associated with to the metastasis of prostate cancer (PCa), in silico analysis of the Gene Expression Omnibus dataset GSE27616, which included 4 metastatic and 5 localized PCa tissue samples, was performed. Differentially expressed genes (DEGs) were identified. Their potential functions were identified by Gene Ontology and Kyoto Encyclopedia of Gene Genomes pathway enrichment analyses. Furthermore, protein-protein interaction (PPI) networks for DEGs were constructed using Cytoscape. Module analysis of the PPI networks was performed with Cluster ONE. A total of 561 DEGs were screened, including 208 upregulated and 353 downregulated genes. Proliferating cell nuclear antigen (PCNA) and cluster of differentiation 4 (CD4) exhibited the highest degrees of connectivity in the PPI networks for up-and down-regulated DEGs, respectively. The DEGs in module A, including CD58, 2, 4 and major histocompatibility complex, class II DP-β1 were enriched in 'cell adhesion molecules'. Anaphase promoting complex subunit 4, cell division cycle 20 and cell division cycle 16 in module B were primarily enriched in 'cell cycle'. The DEGs, including CD4, PCNA and baculoviral IAP repeat containing 5, may have critical roles in PCa metastasis and could thus be used as novel biomarker candidates for metastatic PCa. However, further studies are required to verify these results.

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Differential expression of VEGF ligands and receptors in prostate cancer

Cited by 33 publications

References 41 publications

Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

VEGF expression in pancreatic cancer and other malignancies: a review of the literature

Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis

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