Differential expression of vascular endothelial growth factor, placenta growth factor and their receptors in placentae from pregnancies complicated by placenta accreta

Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections

“…26 Although there is no information related to the utility of monitoring sVEGFR-2 levels in filarial infections, the inverse relationship between sVEGFR-2 and VEGF-A or VEGF-C is similar to that seen in other conditions. [27][28][29] Similarly, increased levels of VEGF and reduced levels of sVEGFR-2 have been shown with the use of inhibitors of cellular VEGF receptor tyrosine kinases VEGF RTKs, including sunitinib, 30 axitinib, 31 and telatinib, 32 suggesting a receptor downregulation-mediated increase in sVEGFR-2. Together with in vitro studies in which VEGFinduced endocytosis of VEGFR-2, resulting in lower levels of sVEGFR-2, 22 it seems possible that sVEGFR-2 levels in the plasma of filaria-infected individuals might influence levels of circulating VEGFs in filarial infections.…”

Histological and histopathological study of the lower uterine segment after previous caesarean section and placenta accreta

“…A study by "Tseng et al, (2006) [32]" has previously noted increased VEGFR expression in a cohort of patients with placenta accreta. The sonographic appearance of intraplacental sonolucent spaces (lakes or lacunae) is a frequent finding in cases of suspected placenta accreta "as solved by (Yang et al, 2006) [33]". The pathophysiology behind the occurrence of placental lacunae is unknown, but their presence suggests an aberrant vascular remodeling pattern "as solved by (Comstock et al, 2004) [34]".…”

Placenta accreta treated with planned caesarean hysterectomy

“…3 Finally, an analytical decision model showed that the preferred gestational age at which to deliver these individuals at high risk is almost certainly at or beyond 34 weeks, but not later than 37 weeks. 7 Management of placenta accreta: There are four basic options for management of placenta accreta: the extirpative method, the cesarean hysterectomy, conservative treatment and the one-step conservative surgery which is an alternative conservative technique. Whatever the option chosen, when placenta accreta is suspected before delivery in a woman with an anterior placenta previa, it is recommended to perform a vertical fundal uterine incision to avoid the placenta and reduce the risk of massive postpartum hemorrhage (PPH).…”

“…This option is currently recommended by the American College of Obstetrics and Gynecology as well as various authors, and is considered the gold standard treatment for placenta accreta. 6,7,[11][12][13] The maternal mortality rate of cesarean hysterectomy seems to be relatively low. Among 95 deaths after 1,461,270 births between 2000 and 2006, only one death secondary to placenta accreta had been reported in the United States.…”