Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses.

Quiding‐Järbrink, Marianne; Nordström, Inger; Granström, Gösta; Kilander, Anders; Jertborn, Marianne; Butcher, Eugene C.; Lazarovits, Andrew I.; Holmgren, Jan; Czerkinsky, Cécil

doi:10.1172/jci119286

Cited by 212 publications

(166 citation statements)

References 43 publications

Supporting

Mentioning

152

Contrasting

Order By: Relevance

“…In contrast, IgA-secreting plasma cells are predominantly induced by a mucosal route of immunization and preferentially localize in the mucosal tissues (2). Differential expression of tissue-specific adhesion molecules has been demonstrated in Ab-secreting cells (ASCs) 4 depending on the route of immunization (3). Recently, chemokines and their receptors have been attracting much attention as the regulators of migration and tissue localization of lymphocytic cells (2,4).…”

Section: 25-dihydroxyvitamin D 3 Induces Ccr10 Expression In Terminmentioning

confidence: 99%

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

Shirakawa

Nagakubo

Hieshima

et al. 2008

The Journal of Immunology

View full text Add to dashboard Cite

In the B cell lineage, CCR10 is known to be selectively expressed by plasma cells, especially those secreting IgA. In this study, we examined the regulation of CCR10 expression in terminally differentiating human B cells. As reported previously, IL-21 efficiently induced the differentiation of activated human CD19+ B cells into IgD−CD38+ plasma cells in vitro. A minor proportion of the resulting CD19+IgD−CD38+ cells expressed CCR10 at low levels. 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the active metabolite of vitamine D3, dramatically increased the proportion of CD19+IgD−CD38+ cells expressing high levels of CCR10. The 1,25-(OH)2D3 also increased the number of CCR10+ cells expressing surface IgA, although the majority of CCR10+ cells remained negative for surface IgA. Thus, 1,25-(OH)2D3 alone may not be sufficient for the induction of IgA expression in terminally differentiating human B cells. To further determine whether 1,25-(OH)2D3 directly induces CCR10 expression in terminally differentiating B cells, we next performed the analysis on the human CCR10 promoter. We identified a proximal Ets-1 site and an upstream potential vitamin D response element to be critical for the inducible expression of CCR10 by 1,25-(OH)2D3. We confirmed the specific binding of Ets-1 and 1,25-(OH)2D3-activated vitamin D receptor to the respective sites. In conclusion, 1,25-(OH)2D3 efficiently induces CCR10 expression in terminally differentiating human B cells in vitro. Furthermore, the human CCR10 promoter is cooperatively activated by Ets-1 and vitamin D receptor in the presence of 1,25-(OH)2D3.

show abstract

Section: 25-dihydroxyvitamin D 3 Induces Ccr10 Expression In Terminmentioning

confidence: 99%

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

Shirakawa

Nagakubo

Hieshima

et al. 2008

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…The integrin ␣ 4 ␤ 7 is expressed by B and T cells responsible for immunity to intestinal Ags (7)(8)(9)(10). Our group has evaluated the importance of ␣ 4 ␤ 7 ϩ lymphocytes in defense against rotavirus (RV), an infectious model of intestinal immunity.…”

mentioning

confidence: 99%

Correlation of Tissue Distribution, Developmental Phenotype, and Intestinal Homing Receptor Expression of Antigen-Specific B Cells During the Murine Anti-Rotavirus Immune Response

Youngman

Franco

Kuklin

et al. 2002

The Journal of Immunology

View full text Add to dashboard Cite

The intestinal homing receptor, α4β7, helps target lymphocytes to Peyer’s patches (PP) and intestinal lamina propria (ILP). We have previously shown that protective immunity to rotavirus (RV), an intestinal pathogen, resides in memory B cells expressing α4β7. In this study, using a novel FACS assay, we have directly studied the phenotype of B cells that express surface RV-specific Ig during the in vivo RV immune response. During primary infection, RV-specific B cells first appear as large IgD−B220lowα4β7− and α4β7+ cells (presumptive extrafollicular, Ab-secreting B cells), and then as large and small IgD−B220highα4β7− cells (presumptive germinal center B cells). The appearance of B cells with the phenotype of large IgD−B220lowα4β7+ cells in PP and most notably in mesenteric lymph nodes coincides with the emergence of RV-specific Ab-secreting cells (ASC) in the ILP. Thus, these B lymphocytes are good candidates for the migratory population giving rise to the RV-specific ASC in the ILP. RV-specific long-term memory B cells preferentially accumulate in PP and express α4β7. Nine months after infection most RV-specific IgA ASC are found in PP and ILP and at lower frequency in bone marrow and spleen. This study is the first to follow changes in tissue-specific homing receptor expression during Ag-specific B cell development in response to a natural host, tissue-specific pathogen. These results show that α4β7 is tightly regulated during the Ag-specific B cell response to RV and is expressed concurrently with the specific migration of memory and effector B cells to intestinal tissues.

show abstract

“…19 Adhesion molecules on ISC may participate in directing migration and homing of ISC to effector sites. 15,37 We found that adhesion molecules CD49d, CD11a and CD162 were also expressed on SG2 and PA4 cells (Fig. 1).…”

Section: Disscusionmentioning

confidence: 84%

“…10,11 After antigenic immunization or stimulation by systemic or mucosal routes, antigen-specific ISC can be found in peripheral blood. 15,16,32 Peripheral blood ISC are considered to be a stage of migration to various secondary and tertiary lymphoid tissues of the body. Determination of antigen-specific ISC in peripheral blood can be used for assessing immunity after immunization.…”

Section: Disscusionmentioning

confidence: 99%

“…13,14 Human circulating ISC are heterogeneous in their expression of either maturation markers or homing receptors (such as CD44, L-selectin, integrins a4 and b7, CD11a and PSGL-1 (CD162)). 15,16 Compared with IgG-and IgM-secreting cells, IgA-secreting cells showed the lowest proportion of cells positive for homing receptors L-selectin and cutaneous lymphocyte antigen (CLA) and for markers of plasma cells (CD38, CD138). 17 However, the information on the expression of surface markers on mouse circulating ISC is very limited.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating immunoglobulin A‐ and immunoglobulin G‐secreting hybridoma cells in peripheral blood preferably migrate to female genital tracts. The role of sex hormones

et al. 2002

View full text Add to dashboard Cite

SUMMARYAntigen-specific circulating immunoglobulin-secreting cells (ISC) migrate to various secondary and tertiary lymphoid tissues. To understand the migration of the cells into the genital tract and its regulation by sex hormones, spleen-derived SG2 hybridoma cells secreting immunoglobulin G2b (IgG2b) and Peyer's patch-derived PA4 hybridoma cells secreting polymer IgA were labelled with 3 H-TdR, and intravenously injected into syngeneic mice of both sexes. Using flow cytometry, surface molecular markers of plasma cells, CD38 and CD138, and adhesion molecules, CD49d, CD162, and CD11a were found to be positive in SG2 and PA4 cells, but CD62L, a4b7 and CD44 were not expressed on these cells. The relative distribution indexes (RDIs) of the cells in genital tract and other tissues were measured. The means of RDIs of SG2 and PA4 cells in female genital tissues were 6 . 5 and 4 . 5 times as many as the means in male genital tissues, respectively. The treatment of ovariectomized mice with b-oestradiol significantly increased the RDIs of PA4 cells in cervix and vagina, but decreased the RDIs of SG2 cells in vagina, horn of uterus, uterus and rectum (P<0 . 05). Progesterone treatment increased the RDIs of PA4 cells in vagina and rectum (P<0 . 05). The treatment with testosterone significantly increased the RDIs of SG2 and PA4 cells in epididymis and accessory sex glands (P<0 . 05). These results demonstrate that the female genital tract is the preferable site for the migration of circulating hybridoma cells to the male genital tract, and sex hormones play an important role in regulation of the migration of circulating ISC to genital tracts.

show abstract

Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses.

Cited by 212 publications

References 43 publications

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

Correlation of Tissue Distribution, Developmental Phenotype, and Intestinal Homing Receptor Expression of Antigen-Specific B Cells During the Murine Anti-Rotavirus Immune Response

Circulating immunoglobulin A‐ and immunoglobulin G‐secreting hybridoma cells in peripheral blood preferably migrate to female genital tracts. The role of sex hormones

Contact Info

Product

Resources

About