Differential expression of tissue factor (TF) in calcineurin inhibitor-induced nephrotoxicity and rejection—implications for development of a possible diagnostic marker

Österholm, Cecilia; Veress, B; Simanaitis, Mečislovas; Hedner, Ulla; Ekberg, Henrik

doi:10.1016/j.trim.2005.06.001

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…These organs are also often affected by conditioning therapy related toxicity and there is evidence that the initial endothelial damage leads to increased release of TF and, thereby, is related to both thrombotic complications and acute GVHD (8 -11). Furthermore, similar observations have been made in heart, liver, kidney, and pancreatic islet transplantation (12)(13)(14)(15). On the other hand, there is abundant evidence, that TF-bearing MPs are associated with cancer progression and angiogenesis and there fore might be useful biomarkers of prognosis (16 -18).…”

mentioning

confidence: 56%

Evaluation of Tissue Factor Bearing Microparticles as Biomarkers in Allogeneic Stem-Cell Transplantation

Rop

Stadler²,

Buchholz³

et al. 2011

Transplantation

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mentioning

confidence: 56%

Evaluation of Tissue Factor Bearing Microparticles as Biomarkers in Allogeneic Stem-Cell Transplantation

Rop

Stadler²,

Buchholz³

et al. 2011

Transplantation

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“…Enhanced PAI-1 expression, which seems to be reduced by rapamycin treatment, might promote chronic allograft nephropathy 198,199 . Increased vascular expression of TF has been observed in chronic, but not in acute allograft nephropathy 200 . In addition, acute ciclosporin-induced nephropathy was associated with increased TF immunoreactivity in the tubular brush border, suggesting that TF expression might be a useful diagnostic marker for this condition 200 .…”

Section: Coagulation Proteases In Renal Diseasementioning

confidence: 99%

“…Increased vascular expression of TF has been observed in chronic, but not in acute allograft nephropathy 200 . In addition, acute ciclosporin-induced nephropathy was associated with increased TF immunoreactivity in the tubular brush border, suggesting that TF expression might be a useful diagnostic marker for this condition 200 . The relevance of this observation remains to be established.…”

Section: Coagulation Proteases In Renal Diseasementioning

confidence: 99%

The emerging role of coagulation proteases in kidney disease

2015

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A role of coagulation proteases in kidney disease beyond their function in normal haemostasis and thrombosis has long been suspected, and studies performed in the past 15 years have provided novel insights into the mechanisms involved. The expression of protease-activated receptors (PARs) in renal cells provides a molecular link between coagulation proteases and renal cell function and revitalizes research evaluating the role of haemostasis regulators in renal disease. Renal cell-specific expression and activity of coagulation proteases, their regulators and their receptors are dynamically altered during disease processes. Furthermore, renal inflammation and tissue remodelling are not only associated, but are causally linked with altered coagulation activation and protease-dependent signalling. Intriguingly, coagulation proteases signal through more than one receptor or induce formation of receptor complexes in a cell-specific manner, emphasizing context specificity. Understanding these cell-specific signalosomes and their regulation in kidney disease is crucial to unravelling the pathophysiological relevance of coagulation regulators in renal disease. In addition, the clinical availability of small molecule targeted anticoagulants as well as the development of PAR antagonists increases the need for in-depth knowledge of the mechanisms through which coagulation proteases might regulate renal physiology.

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“…Podocytes are specialized epithelial cells that express TF [27] and play a pivotal role in the structure and function of the glomerular filtration barrier. The current studies show that absence of the cytoplasmic domain of TF in mice results in spontaneous albuminuria in association with podocyte foot process effacement, consistent with a role for TF in maintenance of normal podocyte structure and function.…”

Section: Discussionmentioning

confidence: 99%

The Cytoplasmic Domain of Tissue Factor Restricts Physiological Albuminuria and Pathological Proteinuria Associated with Glomerulonephritis in Mice

Apostolopoulos

Moussa

Tipping³

2010

Nephron Exp Nephrol

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Background/Aims: Tissue factor (TF) is a transmembrane protein that is essential for coagulation. TF is expressed on podocytes and its cytoplasmic domain has cell signalling functions in epithelial cells. Methods: Mice lacking the cytoplasmic domain of TF (TF^CT–/– mice) were used to study its role in physiological albuminuria and pathological proteinuria following induction of glomerulonephritis (GN). Results: Absence of the cytoplasmic domain of TF was associated with increased albuminuria, podocyte effacement, reduced podocyte numbers and increased spontaneous glomerular tumour necrosis factor α(TNFα) production under physiological conditions. In mice developing GN, absence of the cytoplasmic domain of TF resulted in increased proteinuria and enhanced renal TNFα production without altering other parameters of renal inflammation and injury. Studies in TF^CT–/– chimeric mice (created by bone marrow transplantation) showed increased proteinuria and renal TNFα mRNA in GN was associated with absence of the cytoplasmic domain of TF in the kidney and was independent of the leucocyte phenotype. Conclusion: These studies demonstrate that the cytoplasmic domain of TF contributes to renal albumin retention and its renal expression protects against proteinuria in leucocyte-mediated renal inflammation. Increased glomerular production of TNFα in the absence of cytoplasmic domain of TF may contribute to podocyte injury resulting in albuminuria and proteinuria.

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Differential expression of tissue factor (TF) in calcineurin inhibitor-induced nephrotoxicity and rejection—implications for development of a possible diagnostic marker

Cited by 11 publications

References 32 publications

Evaluation of Tissue Factor Bearing Microparticles as Biomarkers in Allogeneic Stem-Cell Transplantation

Evaluation of Tissue Factor Bearing Microparticles as Biomarkers in Allogeneic Stem-Cell Transplantation

The emerging role of coagulation proteases in kidney disease

The Cytoplasmic Domain of Tissue Factor Restricts Physiological Albuminuria and Pathological Proteinuria Associated with Glomerulonephritis in Mice

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