2001
DOI: 10.1096/fj.00-0051com
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Differential expression of thymosin β‐10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis

Abstract: VPF/VEGF acts selectively on the vascular endothelium to enhance permeability, induce cell migration and division, and delay replicative senescence. To understand the changes in gene expression during endothelial senescence, we investigated genes that were differentially expressed in early vs. late passage (senescent) human dermal endothelial cells (HDMEC) using cDNA array hybridization. Early passage HDMEC cultured with or without VPF/VEGF overexpressed 9 and underexpressed 6 genes in comparison with their se… Show more

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Cited by 205 publications
(158 citation statements)
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“…Much less is known about whether or to what extent the presence of senescent cells contribute to other age-related pathologies. Cells that express SA-Bgal and lack expression of thymosin-b 10, characteristics of senescent endothelial cells in culture have been found at site of atherosclerosis in human aorta (Vasile et al, 2001). Given that senescent cells secrete inflammatory cytokines, and that inflammation is thought to be an important contributory factor in atherogenesis, this result is consistent with the idea that senescent cells can initiate or promote age-related vascular disease.…”
Section: Do Senescent Cells Promote Age-related Pathology?supporting
confidence: 71%
See 1 more Smart Citation
“…Much less is known about whether or to what extent the presence of senescent cells contribute to other age-related pathologies. Cells that express SA-Bgal and lack expression of thymosin-b 10, characteristics of senescent endothelial cells in culture have been found at site of atherosclerosis in human aorta (Vasile et al, 2001). Given that senescent cells secrete inflammatory cytokines, and that inflammation is thought to be an important contributory factor in atherogenesis, this result is consistent with the idea that senescent cells can initiate or promote age-related vascular disease.…”
Section: Do Senescent Cells Promote Age-related Pathology?supporting
confidence: 71%
“…Indeed, such (SABgal-positive) cells have been found in several tissues from humans and rodents. More important, their frequency has been shown to rise with increasing age in human skin, monkey skin and retina, human prostate, rodent kidney, human liver and human vascular endothelium (Dimri et al, 1995;Mishima et al, 1999;Pendergrass et al, 1999;Choi et al, 2000;Ding et al, 2001;Paradis et al, 2001;Vasile et al, 2001;Melk et al, 2003). Moreover, as discussed below, cells with senescent characteristics have been found at sites of age-related pathology, including atherosclerotic plaques and benign and premalignant lesions of the liver and prostate.…”
Section: Do Senescent Cells Exist and Accumulate With Age In Vivo?mentioning
confidence: 99%
“…The presence of cells in vivo, which closely resemble the phenotype of senescent cells replicatively aged in culture, has been observed in human skin (Dimri et al, 1995;Ressler et al, 2006) as well as in the vascular system (Vasile et al, 2001). It is thus conceivable that also stem cells reach an equivalent state of senescence in vivo, but the proof of this hypothesis is still missing.…”
Section: Msc In Vitro Senescencementioning
confidence: 99%
“…Moreover, it might also initiate or promote to certain age-related diseases. For example, atherosclerosis has been proposed to be initiated by the secretions produced by senescent endothelial cells (Chang and Harley, 1995;Vasile et al, 2001). In addition, senescent cells have been proposed to stimulate the progression of cancer (Krtolica et al, 2001), which requires both oncogenic mutations and a disrupted cellular microenvironment in which mutant cells can express their neoplastic phenotype.…”
Section: Cellular Senescencementioning
confidence: 99%