Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers

Chamorro-Petronacci, Cintia; Pérez‐Sayáns, Mario; Padín-Iruegas, María Elena; Marichalar-Mendía, Xabier; Torreira, Mercedes Gallas; Garcı́a, Abel Garcı́a

doi:10.1080/14756366.2018.1426574

Cited by 14 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They ascribed the heterogeneity among studies to differences in study design, sample size, sample type, and origin or population (15). Other recent meta-analyses of OSCC and miRNAs have been conducted by Zahra et al, Zeljic et al, and Troiano et al, which showed some correspondence and some differences in results (7,12,16). Authors conclude that a possible bias in meta-analysis is the origin of the samples.…”

Section: Discussionmentioning

confidence: 99%

“…OSCC prognosis can differ among ethnic groups, as carcinogenic patterns are different, for example, the mutation rates of TP53 are significantly lower in Asian patients than in Caucasian patients (12).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of the miRNA profiling reports on OSCC have been based on Asian samples. Given that an epigenetic mechanism underlies the origin of many cancers, several authors agree on the necessity of studying miRNA profiles from different populations to improve the quality of evidence (12). Also, the ongoing discovery of new miRNAs force investigators to develop new studies with updated technologies to identify such miRNAs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of miR-497-5p and miR-4417 Expression in Oral Squamous Cell Carcinoma and Clinical Parameters

Chamorro-Petronacci¹,

Pérez‐Sayáns²,

Padín-Iruegas³

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

MicroRNAs are small non-coding RNAs that are implicated in several physiological processes such as cell development, proliferation, differentiation, apoptosis, immune response and angiogenesis. In the last couple of decades, several studies on miRNA profiling in OSCC have tried to associate miRNAs with clinical characteristics such as relapse, metastasis, and survival, however, the results have been found to vary considerably, sometimes even being contradictory. The main objective of our study was to analyse and verify miRNA expression in oral squamous cell carcinoma in a Spanish population. Second, we attempted to associate the identified deregulated miRNAs with molecular pathways. 8 Oral Squamous Cell Carcinoma patients and 8 healthy control samples were analysed by a microarray Affymetrix® miRNA 4.1 array plate and validated with 8 more cases using RT-qPCR. Deregulated miRNAs were studied using Diana Tools miRPath 3.0 to associate miRNA targets with molecular pathways. Microarray analysis identified 80 deregulated miRNAs (35 over-expressed and 45 under-expressed). Only miR-497-5p and miR-4417 maintained its deregulated expression after validation with qPCR. Among the molecular pathways in which deregulated miRNAs could be implicated, the most statistically significant pathway was ‘proteoglycans in cancer’. No relationship was found between miR-497-5p or miR-4417 expression and clinical or pathological parameters except of nodular affectation (high miR-4417 expression in patients with nodular affectation, p = 0.035) and radiotherapy (diminished miR-497-5p expression in patients who needed radiotherapy, p = 0.05). We have verified the altered expression of miR-497-5p and miR-4417 in Oral Squamous Cell Carcinoma samples and related the deregulated miRNAs with the ‘proteoglycans in cancer’ pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of miR-497-5p and miR-4417 Expression in Oral Squamous Cell Carcinoma and Clinical Parameters

Chamorro-Petronacci¹,

Pérez‐Sayáns²,

Padín-Iruegas³

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…We first identified several snoRNAs that were correlated with the clinical outcomes of BLCA. Given the stable nature of snoRNAs in the human body, these snoRNAs have inherent advantages for use as molecular biomarkers [ 25 – 27 ]. Regrettably, few studies have assessed snoRNAs as diagnostic and prognostic tools for BLCA.…”

Section: Discussionmentioning

confidence: 99%

Small Nucleolar RNAs (snoRNAs)-Based Risk Score Classifier Predicts Overall Survival in Bladder Carcinoma

Huang

Zhai

et al. 2020

Med Sci Monit

View full text Add to dashboard Cite

“…The microarray comparison made between OSCC tissue and keratinized gums, proved that 14 snoRNAs were down-regulated (displayed in Figure 3 ) and one snoRNA was up-regulated in OSCC. An accentuated down-regulation of mgh18S-121 and ACA17 can be the cause of a worse prognostic [ 123 ].…”

Section: The Small Nucleolar Rnasmentioning

confidence: 99%

The Unforeseen Non-Coding RNAs in Head and Neck Cancer

Irimie

Zimța

Ciocan

et al. 2018

Genes

View full text Add to dashboard Cite

Previously ignored non-coding RNAs (ncRNAs) have become the subject of many studies. However, there is an imbalance in the amount of consideration that ncRNAs are receiving. Some transcripts such as microRNAs (miRNAs) or small interfering RNAs (siRNAs) have gained much attention, but it is necessary to investigate other “pieces of the RNA puzzle”. These can offer a more complete view over normal and pathological cell behavior. The other ncRNA species are less studied, either due to their recent discovery, such as stable intronic sequence RNA (sisRNA), YRNA, miRNA-offset RNAs (moRNA), telomerase RNA component (TERC), natural antisense transcript (NAT), transcribed ultraconserved regions (T-UCR), and pseudogene transcript, or because they are still largely seen as non-coding transcripts with no relevance to pathogenesis. Moreover, some are still considered housekeeping RNAs, for instance small nucleolar RNAs (snoRNAs) and TERC. Our review summarizes the biogenesis, mechanism of action and potential role of less known ncRNAs in head and neck cancer, with a particular focus on the installment and progress for this particular cancer type.

show abstract

Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers

Cited by 14 publications

References 17 publications

Association of miR-497-5p and miR-4417 Expression in Oral Squamous Cell Carcinoma and Clinical Parameters

Association of miR-497-5p and miR-4417 Expression in Oral Squamous Cell Carcinoma and Clinical Parameters

Small Nucleolar RNAs (snoRNAs)-Based Risk Score Classifier Predicts Overall Survival in Bladder Carcinoma

The Unforeseen Non-Coding RNAs in Head and Neck Cancer

Contact Info

Product

Resources

About