Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation

Rodríguez‐Bayona, Beatriz; Ramos-Amaya, Ana; Brieva, José A.

doi:10.1016/j.imlet.2010.09.015

Cited by 16 publications

(14 citation statements)

References 41 publications

(60 reference statements)

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“…TACI is found on human plasma cells, although expression is low in the bone marrow compared to its close relative BCMA . SLAMF7 is highly expressed on human ASCs and multiple myeloma cells, but is also moderately expressed on many immune cells types . The expression of SLAMF7 on natural killer cells has been exploited to develop Elotuzumab, the first approved monoclonal Ab therapy for multiple myeloma that relies on antibody‐dependent cell mediated cytotoxicity directed by natural killer cells against the tumor cells .…”

mentioning

confidence: 99%

Standing out from the crowd: How to identify plasma cells

Tellier

Nutt

2017

Eur J Immunol

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The differentiation of naïve B cells into plasmablasts and plasma cells (collectively termed antibody-secreting cells (ASCs)) is essential for the production of the protective antibodies (Abs) that enable us to fight infection. This developmental process also provides immunity against re-exposure with the same infectious agent, through the generation of long-lived memory B cells and plasma cells, and is the basis for virtually all currently used vaccination strategies. Defective ASC development and function results in immune deficiency, while inability to elicit long-lived Ab production is a common limitation of vaccine utility. In contrast, excess or inappropriate Ab production drives the pathology associated with some autoimmune conditions such as systemic lupus erythematosus and Sjögrens syndrome [1] and is an important and chronic complication of organ transplantation [2].

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confidence: 99%

Standing out from the crowd: How to identify plasma cells

Tellier

Nutt

2017

Eur J Immunol

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“…One mRNA exhibited discordant results between RNA-Seq observations and RT-PCR confirmation. SLAMF4 (CD244) protein has been reported previously not to be expressed on B cell surface at any developmental stage [34,35]. In RNA-Seq experiments we found low-level mRNA expression but up-regulation by RCI (19-fold); in RT-PCR experiments we found that RCI treated cells expressed 45 6 13% of control levels.…”

Section: Discussionmentioning

confidence: 48%

“…SLAMF4 (CD244) protein has been reported previously not to be expressed on B cell surface at any developmental stage [34,35]. SLAMF4 (CD244) protein has been reported previously not to be expressed on B cell surface at any developmental stage [34,35].…”

Section: Discussionmentioning

confidence: 95%

Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids

Benko

McAloose

Becker

et al. 2018

Clinical and Experimental Immunology

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Repository corticotrophin injection (RCI, H.P Acthar gel) has been approved for use in the management of multiple autoimmune and inflammatory diseases for more than a half-century, but its mechanism of action is not well understood. We used RNA-Seq methods to define RCI-regulated mRNAs in cultured human B cells under conditions of activation by interleukin (IL)-4 and CD40 ligand. Following IL-4/CD40L activation and RCI treatment we found up-regulation of 115 unique mRNA transcripts and down-regulation of 80 unique mRNAs. The effect on these RNA levels was dose-dependent for RCI and was distinct from changes in mRNA expression induced by treatment with a potent synthetic glucocorticoid. RCI down-regulated mRNAs were observed to include a significant over-representation of genes critical for B cell proliferation under activating conditions. These data confirm that RCI exerts direct effects on human B cells to modulate mRNA expression in specific pathways of importance to B cell function and that, at the molecular level, the effects of RCI are distinct from those exerted by glucocorticoids.

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“…Similar to innate immune cells, MZ B cells can differentiate into short‐lived plasma cells in the absence of the cross‐linking associated with signaling of B‐cell receptors, primarily in response to blood‐borne thymus‐independent antigens. FO B cells differentiate into Ab‐producing B cells in the germinal center and then further mature into plasma cells and memory B cells to participate in antitumor response …”

Section: Development Of B Cellsmentioning

confidence: 99%

“…FO B cells differentiate into Ab-producing B cells in the germinal center and then further mature into plasma cells and memory B cells to participate in antitumor response. 16,17 In the meantime, the discovery of Bregs has made the field more interesting. Zhou et al 7 showed that stimulation of tumor cell-released autophagosomes (TRAPs) significantly increased the frequency of IL-10 + CD19 + B cells and levels of IL-10 in culture supernatants when splenocytes were cultured with TRAPs.…”

Section: B2 Cellsmentioning

confidence: 99%

A new perspective: Exploring future therapeutic strategies for cancer by understanding the dual role of B lymphocytes in tumor immunity

Liu

Sun

Wang

et al. 2018

Intl Journal of Cancer

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Our previous understanding of the role of B lymphocytes in tumor immunity is its antitumor effects. However, further evidence indicates B lymphocytes can also promote tumorigenesis by modulating immune responses. Therefore, the increasingly complex role of B lymphocytes in tumor immunity may become an important factor in tumor immunotherapy. In this review, we describe the development of B cells in tumor microenvironments. We then focus on the most controversial issues of the biological functions of B lymphocytes. Finally, we nominate B cells as therapeutic targets, which should open broad perspectives for the development of their clinical applications.

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Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation

Cited by 16 publications

References 41 publications

Standing out from the crowd: How to identify plasma cells

Standing out from the crowd: How to identify plasma cells

Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids

A new perspective: Exploring future therapeutic strategies for cancer by understanding the dual role of B lymphocytes in tumor immunity

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