Differential expression of <scp>CXCL</scp>9, <scp>CXCL</scp>10, and <scp>IFN</scp>‐<i>γ</i> in vitiligo and <i>alopecia areata</i> patients

Maouia, Amal; Sormani, Laura; Youssef, M.; Helal, Ahmed Noureddine; Kassab, Asma; Passeron, Thierry

doi:10.1111/pcmr.12559

Cited by 29 publications

(31 citation statements)

References 13 publications

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“…including Hashimoto thyroiditis, Graves disease 29 and alopecia areata. 11 Interestingly, interface dermatitis is the single most common histopathological presentation in the skin pathology of DRESS, 30 and these IP-10-associated autoimmune diseases can be observed in some individuals with DRESS after their recovery.…”

Section: Discussionmentioning

confidence: 99%

“…IP‐10 can be secreted by different types of cells under proinflammatory conditions, including monocytes, activated neutrophils, eosinophils, endothelial cells, keratinocytes26 and thyrocytes27 upon stimulation by interferon‐γ. Previous reports have shown that IP‐10 is associated with interface dermatitis or lichenoid tissue reaction28 and autoimmune diseases including Hashimoto thyroiditis, Graves disease29 and alopecia areata 11. Interestingly, interface dermatitis is the single most common histopathological presentation in the skin pathology of DRESS,30 and these IP‐10‐associated autoimmune diseases can be observed in some individuals with DRESS after their recovery.…”

Section: Discussionmentioning

confidence: 99%

“…7 IP-10 and its receptor CXCR3 have already been found to be associated with autoimmune diseases, including type 1 diabetes, 8 autoimmune thyroiditis, Graves disease, 9 vitiligo 10 and alopecia areata. 11 Interestingly, these diseases may be encountered in patients with DRESS as long-term sequelae. 12 The aim (primary outcome) of this study was to investigate whether IP-10 levels affect the long-term prognosis of DRESS and SJS/TEN.…”

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confidence: 99%

“…Our own recently published article reported that the levels of CXCL10, also known as interferon‐γ‐induced protein (IP)‐10, were significantly higher in patients with DRESS with HHV‐6 reactivation 7. IP‐10 and its receptor CXCR3 have already been found to be associated with autoimmune diseases, including type 1 diabetes,8 autoimmune thyroiditis, Graves disease,9 vitiligo10 and alopecia areata 11. Interestingly, these diseases may be encountered in patients with DRESS as long‐term sequelae 12…”

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confidence: 99%

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The interferon‐γ‐induced protein 10/CXCR3 axis is associated with human herpesvirus‐6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms*

et al. 2020

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Summary Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a condition caused by a drug‐induced immune response. Previous reports have found that CXCL10, also known as interferon‐γ‐induced protein (IP)‐10, may participate in the pathogenesis of cutaneous adverse drug reactions. However, the exact role of IP‐10 in DRESS and Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) has remained unknown. Objectives This comparative prospective cohort study aimed to ascertain the roles of the IP‐10/CXCR3 axis in DRESS and SJS/TEN. Methods Plasma IP‐10 levels were analysed, and univariate analyses were conducted to assess the relationship between IP‐10, human herpesvirus (HHV)‐6 reactivation and the development of long‐term sequelae. We also performed immunohistochemical staining using skin specimens and flow cytometry to determine the expression of CXCR3 in peripheral blood mononuclear cells (PBMCs). Results Significantly higher plasma IP‐10 levels were observed in patients with DRESS with long‐term sequelae (effect size 0·81) and also in those with HHV‐6 reactivation (effect size 0·83). By immunohistochemistry, more abundant IP‐10+ and CXCR3+ cells were demonstrated in the skin lesions of patients with DRESS with HHV‐6 reactivation. The percentages of CLA+ CXCR3+ CD4+ cells and CLA+ CXCR3+ CD8+ cells were also higher in the PBMCs of HHV‐6‐reactivated patients with DRESS than in those of patients with SJS/TEN. Conclusions Higher plasma IP‐10 levels are associated with the development of long‐term sequelae in DRESS. Higher IP‐10/CXCR3 expression in skin and more abundant CLA+ CXCR3+ CD4+ cells and CLA+ CXCR3+ CD8+ cells were observed in patients with DRESS with HHV‐6 reactivation. The IP‐10/CXCR3 axis is associated with HHV‐6 reactivation and development of long‐term sequelae in DRESS. What is already known about this topic? Elevated levels of interferon‐γ‐induced protein‐10 (IP‐10) have been observed in patients with drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Patients with DRESS tend to develop long‐term autoimmune sequelae, including type 1 diabetes and autoimmune thyroiditis. IP‐10 has been associated with these autoimmune diseases in previous studies. What does this study add? The patients with DRESS with HHV‐6 reactivation exhibited higher levels of IP‐10 in the plasma and skin than the patients with DRESS without HHV‐6 reactivation and the patients with SJS/TEN. Patients with DRESS with higher plasma IP‐10 levels tended to develop sequelae during long‐term follow‐up. What is the translational message? IP‐10 is a useful biomarker to predict the development of long‐term sequelae in patients with DRESS. Linked Comment: Belloón and Kardaun. Br J Dermatol 2020; 183:804–805.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The interferon‐γ‐induced protein 10/CXCR3 axis is associated with human herpesvirus‐6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms*

et al. 2020

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“…Clinical signs such as Koebner phenomenon, blurred border, and confetti-like depigmentation have been described as clinical markers of active vitiligo, but these signs only present in a subset of vitiligo patients and are not sufficiently objective 10,11 . Skin tissue biomarkers have been reported, such as basal cell vacuolisation 12 , CD8 + lymphocyte infiltration 13 , and increased expression of heat shock protein-70 14 , CXCL9 15 , and sCD25 16 . However, skin biopsy is a traumatic examination and it is difficult to apply to patients with more than one active period.…”

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confidence: 99%

Urinary metabolomic investigations in vitiligo patients

Liu

Qian

et al. 2020

Sci Rep

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Urinary metabolomics is a useful non-invasive tool for large-scale screening of disease-related metabolites. However, no comprehensive urinary metabolomic analysis of vitiligo is presently available. To investigate the urine metabolic pattern of vitiligo patients, we conducted a combined cross-sectional and prospective self-control cohort study and an untargeted urinary metabolomic analysis. In the cross-sectional study, 295 vitiligo patients and 192 age‐ and sex‐matched controls were enrolled, and 71 differential metabolites between two groups were identified. Pathway enrichment analysis revealed that drug metabolism-cytochrome P450, biopterin metabolism, vitamin B9 (folate) metabolism, selenoamino acid metabolism, and methionine and cysteine metabolism showed significant enrichment in vitiligo patients compared with the status in healthy controls. In the self-control cohort, 46 active vitiligo patients were recruited to analyse the urinary metabolic signatures after treatment. All of these patients were asked to undertake follow-up visits every 2 months three times after first consulting and the disease stage was evaluated compared with that at the last visit. Folate metabolism, linoleate metabolism, leukotriene metabolism, alkaloid biosynthesis, and tyrosine metabolism were predicted to be involved in vitiligo activity. Our study is the first attempt to reveal urinary metabolic signatures of vitiligo patients and provides new insights into the metabolic mechanisms of vitiligo.

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Association of Clinical Markers With Disease Progression in Patients With Vitiligo From China

et al. 2020

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IMPORTANCEIt is necessary to determine whether established clinical markers of vitiligo are associated with disease progression, severity, and patient prognosis.OBJECTIVE To evaluate the utility of trichrome sign, confetti-like depigmentation, and Koebner phenomenon in assessing disease progression, severity, and prognosis in patients with vitiligo. DESIGN, SETTING, AND PARTICIPANTSIn this prospective cohort study, 425 patients with vitiligo were recruited from the outpatient department of

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Differential expression of CXCL9, CXCL10, and IFN‐γ in vitiligo and alopecia areata patients

Cited by 29 publications

References 13 publications

The interferon‐γ‐induced protein 10/CXCR3 axis is associated with human herpesvirus‐6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms*

The interferon‐γ‐induced protein 10/CXCR3 axis is associated with human herpesvirus‐6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms*

Urinary metabolomic investigations in vitiligo patients

Association of Clinical Markers With Disease Progression in Patients With Vitiligo From China

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