Differential Expression of Prostaglandin E2 Receptors in Porcine Kidney Transplants

Harner, Andrew; Wang, Youli; Fang, Xuexiu; Merchen, Todd; Cox, Philip B.; Ho, Sam; Kleven, Daniel; Thompson, Thomas L.; Nahman, N. S.

doi:10.1016/j.transproceed.2019.05.016

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Prostaglandins1

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2022

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“…PGE 2 mediates local renal effects through four different E prostanoid cell-surface receptors (EP1-4), which are expressed in both human and pig kidneys. 73 Humans and pigs also have the same enzyme that processes PGE 2 (prostaglandin 9-ketoreductase). 74 While pig kidneys can produce intrinsic PGE 2 , it is likely that pig kidneys will also process human PGE 2 .…”

Section: Prostaglandinsmentioning

confidence: 99%

Physiological aspects of pig kidney xenotransplantation and implications for management following transplant

Hansen‐Estruch

Cooper

Judd

2022

Xenotransplantation

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Successful organ transplantation between species is now possible, using genetic modifications. This article aims to provide a comprehensive overview of the differences and similarities in kidney function between humans, primates, and pigs, in preparation for pig-allograft to human xenotransplantation. The kidney, as the principal defender of body homeostasis, acts as a sensor, effector, and regulator of physiologic feedback systems. Considerations are made for anticipated effects on each system when a pig kidney is placed into a human recipient. Discussion topics include anatomy, global kidney function, sodium and water handling, kidney hormone production and response to circulating hormones, acid-base balance, and calcium and phosphorus handling. Based on available data, pig kidneys are anticipated to be compatible with human physiology, despite a few barriers.

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Section: Prostaglandinsmentioning

confidence: 99%