Differential Expression of Proinflammatory Cytokines and Their Inhibitors during the Course of Meningococcal Infections

Deuren, Marcel van; Jongekrijg, Johanna; Demacker, P.N.M.; Bartelink, A. K. M.; Dalen, R. van; Sauerwein, Robert W.; Gallati, H.; Vannice, James L.; Meer, J.W.M. van der

doi:10.1093/infdis/169.1.157

Cited by 161 publications

(93 citation statements)

References 60 publications

(38 reference statements)

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“…The high dosages of corticosteroids were only given to patients with PO 2 Յ 8 kPa. Thus, severe infection could also be responsible for suppression of proinflammatory cytokine production [31,37,38]. In four of four patients with PCP (two HIV+ from the present series and two HIV- [20]), blood was taken before and after high-dose corticosteroids; in three of these patients we found that cytokine production was already suppressed before administration of steroids.…”

Section: Cytokines In Hiv+ Patients With Pcp 337mentioning

confidence: 45%

**Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV‐seropositive patients with Pneumocystis carinii pneumonia**

Perenboom

Sauerwein²,

Beckers³

et al. 1997

Eur J Clin Investigation

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Abstract. Concentrations and ex vivo production of interleukin 1b (IL-1), tumour necrosis a (TNF), interleukin 6 (IL-6), interleukin-1 receptor antagonist (IL-1RA) and TNF soluble receptors (sTNF-receptors, P55 and P75) were measured in bronchoalveolar lavage (BAL) fluid and blood in 23 HIV-seropositive (HIV+) patients with Pneumocystis carinii pneumonia (PCP) and compared with values found in healthy HIV-seronegative (HIV-) controls and asymptomatic HIV+ subjects. Concentrations of the proinflammatory cytokine IL-1b were increased in BAL fluid of HIV+ patients with PCP (184 Ϯ 47 pg mL -1 ) compared with undetectable levels in healthy control subjects (P = 0 . 0001). In plasma of these patients higher concentrations of the anti-inflammatory cytokine IL-1RA were found during acute PCP than after recovery (2 . 1 Ϯ 0 . 7 vs. 0 . 5 Ϯ 0 . 2 ng mL -1 , P = 0 . 01). No correlations could be found between cytokine concentrations and clinical severity of the infection. Corticosteroid treatment did not influence cytokine concentrations in BAL or blood, nor did it suppress the production in alveolar cells. In whole-blood cultures, however, lipopolysaccharide (LPS)-stimulated production was significantly suppressed for IL-1 (1 . 3 vs. 5 . 5 ng mL -1 , P = 0 . 009) and for IL-6 (0 . 6 vs. 2 . 5 ng mL -1 , P = 0 . 01). The overall data show that in HIV+ patients with PCP (similar to what we had found previously in HIVpatients with PCP) proinflammatory cytokines are more prominently present in BAL, whereas anti-inflammatory reaction is predominant in the circulation.

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Section: Cytokines In Hiv+ Patients With Pcp 337mentioning

confidence: 45%

**Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV‐seropositive patients with Pneumocystis carinii pneumonia**

Perenboom

Sauerwein²,

Beckers³

et al. 1997

Eur J Clin Investigation

Self Cite

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“…Higher concentrations can be found in severe disease states such as septic shock, burn trauma, and after experimental administration of endotoxin [29][30][31][32]. In rheumatoid arthritis patients, dietary fish oil supplementation during 12 weeks resulted in decreased circulating concentrations of IL-1b [33].…”

Section: Discussionmentioning

confidence: 99%

Pro‐ and anti‐inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year

Blok

Deslypère

Demacker

et al. 1997

Eur J Clin Investigation

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120

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Abstract. Dietary supplementation with n-3 fatty acids from fish oil alleviates inflammation in various chronic inflammatory disease states. Reductions in the production of pro-inflammatory cytokines interleukin 1b (IL1b), tumour necrosis factor alpha (TNF-a), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation. We investigated longterm effects of dietary n-3 fatty acids on circulating cytokine concentrations and on ex vivo stimulated whole-blood production of IL-1b, TNF-a and interleukin 1 receptor antagonist (IL-1Ra), the naturally occurring antagonist of IL-1. A total of 58 monks with a mean age of 56 years were randomized into four groups and their diets were supplemented with 0, 3, 6, or 9 g of fish oil, providing 0, 1·06, 2·13 or 3·19 g of n-3 fatty acids per day. Subjects received equal amounts of saturated fatty acids, vitamin E and cholesterol. Compliance was excellent and erythrocyte fatty acid profiles closely reflected the amounts of n-3 fatty acids ingested. In the group receiving 9 g of fish oil per day, no influence of n-3 fatty acids on circulating cytokine concentrations was observed relative to placebo. Endotoxin-stimulated whole-blood cytokine production was measured at 26 and 52 weeks after the start and at 4, 8 and 26 weeks after cessation of supplementation. In all groups, the production of IL-1b and IL-1Ra was higher during supplementation than afterwards. However, no differences in cytokine production were noted between the placebo group and the various treatment groups at any point in time. Our results suggest that long-term supplementation of fish oil does not affect ex vivo cytokine production in man.

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“…These tests represent reliable methods to assess the phenomenon of endotoxin tolerance defined as a reduced responsiveness to a secondary LPS challenge following a first inflammatory response. Monocytes from septic patients usually present with a diminished capacity to release tumor necrosis factor (TNF)-α, IL-1α, IL-6, and IL-12, whereas the release of anti-inflammatory mediators (IL-1ra, IL-10) is not affected or even slightly increased (33)(34)(35)(36)(37)(38). This shows that LPS can still activate monocytes but that the intracellular signaling has been turned to favor production of anti-inflammatory molecules, therefore supporting the concept of leukocyte reprogramming (39,40).…”

Section: Functional Testingmentioning

confidence: 99%

Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony

Monneret

Venet

Pachot

et al. 2008

Mol Med

298

323

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Differential Expression of Proinflammatory Cytokines and Their Inhibitors during the Course of Meningococcal Infections

Cited by 161 publications

References 60 publications

**Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV‐seropositive patients with Pneumocystis carinii pneumonia**

**Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV‐seropositive patients with Pneumocystis carinii pneumonia**

Pro‐ and anti‐inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year

Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony

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