Differential Expression of NUDT9 at Different Phases of The Menstrual Cycle and in Different Components of Normal and Neoplastic Human Endometrium

Chen, Lingyun; Chen, Tze-Ho; Wen, Pao-Ying; Chou, Chia-Hung; Ying, Tsung-Ho; Chang, Shun‐Ping; Ma, Gwo‐Chin; Chen, Ming

doi:10.1016/s1028-4559(09)60266-7

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Despite the identified dual functionality of c-FLIPL as a pro- or antiapoptotic factor in normal tissues, c-FLIPL has generally been shown to act as a key negative regulator of apoptosis in human cancer cells [38, 39]. Increased expression of c-FLIP has been detected in many human malignancies, including melanoma, hepatocellular carcinoma [40], nonsmall cell lung carcinoma [40], and endometrial [41], colon [42], and prostate cancer [43–45]. While its overexpression has been associated with cancer progression and/or poor prognosis in BL, HCC, and ovarian, endometrial, colon, and prostate cancer [38, 39, 42, 46], elevated expression of c-FLIP blocks caspase-8 and renders cells resistant to cell receptor-mediated apoptosis [38].…”

Section: Apoptosis Defect and Cancermentioning

confidence: 99%

Apoptosis and Molecular Targeting Therapy in Cancer

Hassan

Watari

Abu-Almaaty

et al. 2014

BioMed Research International

927

720

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Apoptosis is the programmed cell death which maintains the healthy survival/death balance in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. The apoptotic signals are complicated and they are regulated at several levels. The signals of carcinogenesis modulate the central control points of the apoptotic pathways, including inhibitor of apoptosis (IAP) proteins and FLICE-inhibitory protein (c-FLIP). The tumor cells may use some of several molecular mechanisms to suppress apoptosis and acquire resistance to apoptotic agents, for example, by the expression of antiapoptotic proteins such as Bcl-2 or by the downregulation or mutation of proapoptotic proteins such as BAX. In this review, we provide the main regulatory molecules that govern the main basic mechanisms, extrinsic and intrinsic, of apoptosis in normal cells. We discuss how carcinogenesis could be developed via defective apoptotic pathways or their convergence. We listed some molecules which could be targeted to stimulate apoptosis in different cancers. Together, we briefly discuss the development of some promising cancer treatment strategies which target apoptotic inhibitors including Bcl-2 family proteins, IAPs, and c-FLIP for apoptosis induction.

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Section: Apoptosis Defect and Cancermentioning

confidence: 99%

Apoptosis and Molecular Targeting Therapy in Cancer

Hassan

Watari

Abu-Almaaty

et al. 2014

BioMed Research International

927

720

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“…The newly discovered SNP11 in this study is located in NUDT9, a gene that can regulate the menstrual cycle [38]. This suggests that SNP11 is an SNP related to goose broodiness.…”

Section: Discussionmentioning

confidence: 59%

Whole Genome Resequencing Identifies Single-Nucleotide Polymorphism Markers of Growth and Reproduction Traits in Zhedong and Zi Crossbred Geese

Liu¹,

Guo²,

Zhao³

et al. 2023

Genes

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: The broodiness traits of domestic geese are a bottleneck that prevents the rapid development of the goose industry. To reduce the broodiness of the Zhedong goose and thus improve it, this study hybridized it with the Zi goose, which has almost no broody behavior. Genome resequencing was performed for the purebred Zhedong goose, as well as the F2 and F3 hybrids. The results showed that the F1 hybrids displayed significant heterosis in growth traits, and their body weight was significantly greater than those of the other groups. The F2 hybrids showed significant heterosis in egg-laying traits, and the number of eggs laid was significantly greater than those of the other groups. A total of 7,979,421 single-nucleotide polymorphisms (SNPs) were obtained, and three SNPs were screened. Molecular docking results showed that SNP11 located in the gene NUDT9 altered the structure and affinity of the binding pocket. The results suggested that SNP11 is an SNP related to goose broodiness. In the future, we will use the cage breeding method to sample the same half-sib families to accurately identify SNP markers of growth and reproductive traits.

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Differential Expression of NUDT9 at Different Phases of The Menstrual Cycle and in Different Components of Normal and Neoplastic Human Endometrium

Abstract: We suggest that NUDT9 may be involved in the regulation of the menstrual cycle and may be related to the proliferation of glandular cells in the human endometrium.

Cited by 2 publications

References 24 publications

Apoptosis and Molecular Targeting Therapy in Cancer

Apoptosis and Molecular Targeting Therapy in Cancer

Whole Genome Resequencing Identifies Single-Nucleotide Polymorphism Markers of Growth and Reproduction Traits in Zhedong and Zi Crossbred Geese

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