2019
DOI: 10.1016/j.clinbiochem.2019.04.007
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Differential expression of miR-155 and Let-7a in the plasma of childhood asthma: Potential biomarkers for diagnosis and severity

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Cited by 36 publications
(34 citation statements)
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“…Another study performed within 100 asthmatic children and 100 healthy controls identified increased levels of miR-155 and decreased level of Let-7a in peripheral blood of asthmatics than controls. The relative levels of miR-155 and Let-7a also performed well in differentiating severe asthma from mild and moderate asthma [50]. MiR-155 was reported to play an important role in regulating type 2 innate lymphoid cells and IL-33 signaling of allergic airway inflammation in murine models [51].…”
Section: Studies Of Noncoding Rna and Asthma Developmentmentioning
confidence: 88%
See 1 more Smart Citation
“…Another study performed within 100 asthmatic children and 100 healthy controls identified increased levels of miR-155 and decreased level of Let-7a in peripheral blood of asthmatics than controls. The relative levels of miR-155 and Let-7a also performed well in differentiating severe asthma from mild and moderate asthma [50]. MiR-155 was reported to play an important role in regulating type 2 innate lymphoid cells and IL-33 signaling of allergic airway inflammation in murine models [51].…”
Section: Studies Of Noncoding Rna and Asthma Developmentmentioning
confidence: 88%
“…Next to the study of asthma phenotype, several previous studies showed epigenetic marks such as DNA methylation and miRNA that also associated with specific characteristics of asthma such as severity of asthma, sensitivity to ICS, and exhaled NO [48,50,109], which suggested that epigenetic marks may also be associated with specific asthma endotypes and that the epigenetics may assist in understanding the clinical heterogeneity of asthma in the future.…”
Section: Expert Opinionmentioning
confidence: 99%
“…Plasma miRNA‐155 positively correlated with IL‐13 levels but negatively correlated with FEV 1 and FVC in patients with asthma . Furthermore, miR‐155 contributes to Th2 effector function, and miR‐155‐deficient mice exhibited significantly reduced airway inflammation and eosinophilia in response to HDM challenge and in a model of ovalbumin (OVA)‐induced allergic airway inflammation .…”
Section: Bronchial Asthma and Mirnamentioning
confidence: 99%
“…Furthermore, miR‐155 contributes to Th2 effector function, and miR‐155‐deficient mice exhibited significantly reduced airway inflammation and eosinophilia in response to HDM challenge and in a model of ovalbumin (OVA)‐induced allergic airway inflammation . The transcription factor PU.1, which is a negative regulator of type‐2 cytokine production, is a putative miR‐155 target identified in Th2 cells . miR‐155 expression was drastically upregulated in the lungs of OVA‐challenged mice compared with that in the lungs of control mice .…”
Section: Bronchial Asthma and Mirnamentioning
confidence: 99%
“…Furthermore, pivotal roles of miRNAs have been demonstrated in a number of biological processes, including cell proliferation, differentiation, cell cycle and cell apoptosis (10). Emerging studies have reported differentially expressed miRNAs in different types of human diseases (11)(12)(13). The clinical significance of the aberrant expression of miRNAs has attracted increasing attention due to their high diagnostic and prognostic values (14,15).…”
Section: Introductionmentioning
confidence: 99%