Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status

Rask, Lene; Balslev, Eva; Søkilde, Rolf; Høgdall, Estrid; Flyger, Henrik; Eriksen, Jens; Litman, Thomas

doi:10.1007/s13402-014-0176-6

Cited by 64 publications

(54 citation statements)

References 59 publications

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“…For example, miR-139-5p was reported to be expressed at lower levels in breast cancer samples vs. healthy controls (35,44,45). Mammography, now as the standard screening tool worldwide for early breast cancer, has certain limitations (44).…”

Section: Mir-139-5p In Cancer Diagnosismentioning

confidence: 99%

Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy

Huang

Wang

et al. 2017

Oncology Letters

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MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role in tumorigenesis, metastasis and recurrence, thus suggesting that it may potentially be used as a promising biomarker for cancer diagnosis, prognosis and therapy. miR-139-5p is expected to serve as a biomarker to eventually be implemented in a clinical setting. In the present review, we focus on the importance of miR-139-5p in cancer, summarize the association between miR-139-5p expression level and diagnosis and prognosis, and discuss the potential therapeutic implications for the future.

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Section: Mir-139-5p In Cancer Diagnosismentioning

confidence: 99%

Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy

Huang

Wang

et al. 2017

Oncology Letters

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“…These precursors are cleaved in the nucleus by the Bmicroprocessor complexŵ hich contains an RNase III endonuclease called Drosha and Di George critical region 8 (DGCR8). The resulting intermediate is approximately 70 nucleotides long and forms a hairpin-containing secondary structure called Bprecursor miRNA^(pre-miRNA) [8,13]. Next, this pre-miRNA is transported to the cytoplasm where it is further processed by another RNase III endonuclease, Dicer, to release the mature and fully functional double stranded BmiRNA^ [8,14], which can be incorporated into the RNA-induced silencing complex (RISC) [15].…”

Section: Introductionmentioning

confidence: 99%

Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas

et al. 2015

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“…Breast cancer is associated with the highest incidence and death rates among woman in western countries [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Myoepithelial and luminal breast cancer cells exhibit different responses to all-trans retinoic acid

et al. 2015

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Our results show that the luminal epithelial (LEP) and myoephitelial (MEP) mammary LM38-P subpopulations respond differently to ATRA, i.e., the LEP subpopulation responds with increased cell cycle arrest and apoptosis and the MEP subpopulation responds with increased senescence and adhesion, thereby decreasing its invasive capacity. Finally, we identified a third subpopulation with stem/progenitor cell characteristics within the LM38-LP mammary adenocarcinoma cell line, which appears to be non-responsive to ATRA.

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Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status

Abstract: Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients.

Cited by 64 publications

References 59 publications

Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy

Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy

Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas

Myoepithelial and luminal breast cancer cells exhibit different responses to all-trans retinoic acid

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