Differential Expression of MicroRNAs in Chronic Obstructive Pulmonary Disease

Kara, Murat; Kırkıl, Gamze; Kalemci, Serdar

doi:10.17219/acem/28343

Cited by 37 publications

(48 citation statements)

References 17 publications

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“…And, it is widely known that lung cancer is one of the comorbidities of COPD. Previous studies13,34,52,53 have suggested miR-125 to be an important regulatory factor related to inflammation and further proposed that miR-125 might be connected with COPD and involved in disease pathogenesis; however, the authors did not expound the specific relationship. We found miR-125a-5p to be upregulated in COPD in all ABCD groups, which was confirmed via qRT-PCR in large samples (Table 5 and Figure 5B), and it might also be involved in the Wnt signaling pathway via its targeted gene SMAD4, thus affecting the process of COPD.…”

Section: Discussionmentioning

confidence: 91%

“…By next-generation sequencing, we found 1,715 differentially expressed miRNAs, and 7 miRNAs (hsa-miR-3177-3p, hsa-miR-19b-3p, hsa-miR-3613-5p, hsa-miR-93-5p, hsa-miR-29a-3p, hsa-miR-142-5p, and hsa-miR-19a-3p) might be novel in COPD. 12 miRNAs (miR-342-3p,32 miR-17-5p,13 miR-16-5p,13 miR-29b-3p,32,33 miR-26b-5p,33 miR-125a-5p,13,34 miR-106b-5p,33 miR-223-3p,35 miR-142-3p,36 miR-30b-5p,36 miR-374a-5p,37 and miR-451a37) had been reported in previous COPD studies. It has been reported that miR-29b38 and miR-106b39 are involved in TGF-β1 signaling.…”

Section: Discussionmentioning

confidence: 99%

“…The authors12 revealed miR-3620-3p as a promising biomarker, separating COPD and asthma. Kara et al13 demonstrated that miR-29c and miR-126 are essential for the development of COPD.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral leukocyte microRNAs as novel biomarkers for COPD

Wang¹,

Xu²,

Liu³

et al. 2017

COPD

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COPD is a multifactorial disease caused by environmental determinants as well as genetic risk factors. The prevalence and mortality of COPD continue to increase, and underdiagnosis of COPD remains a critical issue. Previous reports investigated promising microRNAs (miRNAs) to reveal the molecular mechanism for the development of COPD; however, diagnostic and therapeutic markers for COPD have not yet been found. For this study, 20 representative COPD patients were separated into four groups based on increasing severity (A, B, C, and D) and compared to six healthy controls. Small RNA profiles of peripheral leukocytes were differentially expressed miRNAs (analyzed via next-generation sequencing) were validated via quantitative reverse transcriptase-polymerase chain reaction. Compared to healthy controls, 19 differentially expressed miRNAs were found in COPD patients. For all COPD groups, miR-3177-3p was downregulated, while 17 miRNAs were upregulated. Furthermore, the results revealed 21 differentially expressed miRNAs, of which miR-183-5p was continually downregulated from A to B to D. Between respective bronchodilator reversibility positive and negative groups of COPD different groups (A, B, C, and D), 10 miRNAs were differentially expressed, while miR-100-5p was upregulated in the negative groups. In conclusion, miR-106b-5p, miR-125a-5p, miR-183-5p, and miR-100-5p are central for the development of COPD. The severity of COPD was attenuated by miR-106b-5p, thus suggesting this miRNA as potential target for disease treatment.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Peripheral leukocyte microRNAs as novel biomarkers for COPD

Wang¹,

Xu²,

Liu³

et al. 2017

COPD

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“…There is mounting evidence that miRNA expression is altered in these diseases, potentially impairing immunity against pathogens in the lung; however, few studies have been published describing the role of individual miRNA in these diseases [75][76][77] . Microarray analysis of COPD lung samples identified miRNA-218-5p as being downregulated in the airway epithelium [78] .…”

Section: Mirna In Inflammatory Respiratory Diseasementioning

confidence: 99%

Role of MicroRNA in the Lung's Innate Immune Response

Cohen¹

2016

J Innate Immun

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The immune response to respiratory pathogens must be robust enough to defend the host yet properly constrained such that inflammation-induced tissue damage is avoided. MicroRNA (miRNA) are small noncoding RNA which posttranscriptionally influence gene expression. In this review, we discuss recent experimental evidence of the contribution of miRNA to the lung's response to bacterial and viral pathogens.

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“…Wraz z wiekiem istotnie statystycznie wzrasta zachorowalność na POChP [5]. Patogeneza tego schorzenia jest wieloczynnikowa [6]. Odnosi się ona zarówno do aspektów genetycznych, jak i środowiskowych i obejmuje zapalenie (przewlekłe zapalenie oskrzeli), utratę powierzchni pęcherzyków płucnych oraz zniszczenie oskrzelików oddechowych [7].…”

Section: Wstępunclassified

Wybrane aspekty opieki pielęgniarskiej w opiece nad pacjentem w podeszłym wieku z przewlekłą obturacyjną chorobą płuc - studium przypadku

Filipska¹

2016

IwP

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Obejmuje on także problemy pielęgnacyjne, jakie występują u chorej oraz interwencje, które powinna podjąć pielęgniarka, by zredukować bądź całkowicie wyeliminować zdiagnozowane i zaobserwowane problemy. Prezentowane studium przypadku jest opisem teoretycznym. Dyskusja. POChP ze względu na swój przewlekły charakter i szerokie rozpowszechnienie uznawana jest za jeden z najistotniejszych problemów zdrowia publicznego. Częstotliwość zachorowań wzrasta wraz z wiekiem. Odnotowano, że szczyt zachorowań najczęściej występuję w szóstej dekadzie życia. Główną rolą pielęgniarki w opiece nad pacjentem z tą jednostką chorobową jest wykonywanie profesjonalnych czynności pielęgnacyjnych, leczniczych, rehabilitacyjnych i diagnostycznych. Istotny aspekt stanowi również edukacja, która powinna być przeprowadzana przez pielęgniarki w trakcie pobytu chorego na oddziale. Wnioski. W obliczu pogorszającego się sukcesywnie funkcjonowania psychospołecznego osób starszych z POCHP warto byłoby się zastanowić nad wprowadzeniem przesiewowych badań w kierunku wczesnego wykrywania tej jednostki chorobowej np. w placówkach podstawowej opieki zdrowotnej. Należy także dążyć do wprowadzania licznych programów przeciwdziałających POCHP, a także uświadamiających społeczeństwo o identyfikowaniu POCHP z oddzielną jednostką chorobową, a nie utożsamianiu jej z naturalnym elementem procesu starzenia się. Abstract:Introduction. COPD is a chronic pulmonary progressively increasing the number of morbidity and mortality. It is characterized by progressive and irreversible airflow limitation by inhalation. It has been shown that the disease is diagnosed here it is nearly 8-10% of Europeans after 30 years of age. As people age significantly increasing incidence of chronic diseases.

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Differential Expression of MicroRNAs in Chronic Obstructive Pulmonary Disease

Cited by 37 publications

References 17 publications

Peripheral leukocyte microRNAs as novel biomarkers for COPD

Peripheral leukocyte microRNAs as novel biomarkers for COPD

Role of MicroRNA in the Lung's Innate Immune Response

Wybrane aspekty opieki pielęgniarskiej w opiece nad pacjentem w podeszłym wieku z przewlekłą obturacyjną chorobą płuc - studium przypadku

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