Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients

Fan, Huiying; Sun, Xiaochuan; Guo, Wei; Zhong, Aihua; Niu, Wei; Zhao, Lin; Dai, Yong; Guo, Zhen; Zhang, Liyi; Lu, Jim

doi:10.1016/j.jpsychires.2014.08.007

Cited by 112 publications

(68 citation statements)

References 55 publications

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“…We evaluated miRNA level changes in the whole blood of depressed patients after 12 weeks of antidepressant treatment with escitalopram, reporting a significant modulation for 30 miRNAs, potentially implicated in several biological pathways associated with brain functions (Bocchio-Chiavetto et al, 2013). Other studies conducted on peripheral blood mononuclear cells from MD patients, compared to healthy controls, reported a differential expression of 14 (Belzeaux et al, 2012) and 5 miRNAs (Fan et al, 2014). Moreover, after an effective 8-weeks treatment with different classes of antidepressant drugs, a modulation was detected for 8 miRNAs (Belzeaux et al, 2012).…”

Section: Introductionmentioning

confidence: 82%

Peripheral whole blood microRNA alterations in major depression and bipolar disorder

Maffioletti

Cattaneo

Rosso

et al. 2016

Journal of Affective Disorders

143

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Major depression (MD) and bipolar disorder (BD) are severe and potentially life-threating mood disorders whose etiology is to date not completely understood. MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein synthesis post-transcriptionally by base-pairing to target gene mRNAs. Growing evidence indicated that miRNAs might play a key role in the pathogenesis of neuropsychiatric disorders and in the action of psychotropic drugs. On these bases, in this study 1 These authors contributed equally to this work 2 we evaluated the expression levels of the entire miRNome 1733 mature miRNAs annotated in miRBase v.17, through a microarray technique, in the blood of 20 MD and 20 BD patients and 20 healthy controls, in order to identify putative miRNA signatures associated with mood disorders.We found that 5 miRNAs (hsa-let-7a-5p, hsa-let-7d-5p, hsa-let-7f-5p, hsa-miR-24-3p and hsa-miR-425-3p) were specifically altered in MD patients and 5 (hsa-miR-140-3p, hsa-miR-30d-5p, hsamiR-330-5p, hsa-miR-378a-5p and hsa-miR-21-3p) in BD patients, whereas 2 miRNAs (hsa-miR-330-3p and hsa-miR-345-5p) were dysregulated in both the diseases. The bioinformatic prediction

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Section: Introductionmentioning

confidence: 82%

Peripheral whole blood microRNA alterations in major depression and bipolar disorder

Maffioletti

Cattaneo

Rosso

et al. 2016

Journal of Affective Disorders

143

View full text Add to dashboard Cite

show abstract

“…Fan et al [112] explored miRNAs expression in PBMC as specific blood-based biomarker for MDD patients, identifying 26 miRs with significant expression changes. After validating in a larger cohort, five miRs (miR-26b, miR-1972, miR-4485, miR-4498, and miR-4743) were found up-regulated, which would be controlling pathways associated with the nervous system and brain functions [112].…”

Section: Epigenetic Modifications and Depressive Disordersmentioning

confidence: 99%

Epigenetic Modifications of Major Depressive Disorder

Saavedra

Molina-Márquez

Saavedra

et al. 2016

IJMS

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Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression could favor MDD advance in response to stressful experiences and environmental factors. The aim of this review is to describe genetic alterations, and particularly altered epigenetic mechanisms, that could be determinants for MDD progress, and how these alterations may arise as useful screening, diagnosis and treatment monitoring biomarkers of depressive disorders.

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“…More recently, Fan et al (2014) profiled miRNAs in peripheral blood mononuclear cells of 81 MDD patients and 46 healthy controls. They found that the expression levels of 5 miRNAs (miRNA-26b, miRNA-1972, miRNA-4485, miRNA-4498, and miRNA-4743) were up-regulated.…”

Section: Blood Cell Mirnas: a Valuable Source For Biomarker Discoverymentioning

confidence: 99%

Pathogenetic and therapeutic applications of microRNAs in major depressive disorder

Dwivedi

2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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As a class of noncoding RNAs, microRNAs (miRNAs) regulate gene expression by inhibiting translation of messenger RNAs. These miRNAs have been shown to play a critical role in higher brain functioning and actively participate in synaptic plasticity. Pre-clinical evidence demonstrates that expression of miRNAs is differentially altered during stress. On the other hand, depressed individuals show marked changes in miRNA expression in brain. MiRNAs are also target of antidepressants and electroconvulsive therapy. Moreover, these miRNAs are present in circulating blood and can be easily detected. Profiling of miRNAs in blood plasma/serum provide evidence that determination of miRNAs in blood can be used as possible diagnostic and therapeutic tool. In this review article, these aspects are critically reviewed and role of miRNAs in possible etiopathogenesis and therapeutic implications in the context of major depressive disorder is discussed.

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Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients

Cited by 112 publications

References 55 publications

Peripheral whole blood microRNA alterations in major depression and bipolar disorder

Peripheral whole blood microRNA alterations in major depression and bipolar disorder

Epigenetic Modifications of Major Depressive Disorder

Pathogenetic and therapeutic applications of microRNAs in major depressive disorder

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