Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development

Zúñiga-García, Violeta; Chávez-López, María de Guadalupe; Quintanar-Jurado, Valeria; Gabiño-López, Nayeli Belem; Hernández-Gallegos, Elisabeth; Soriano-Rosas, Juan; Pérez‐Carreón, Julio Isael; Camacho, Javier

doi:10.1007/s10620-015-3633-9

Cited by 29 publications

(16 citation statements)

References 43 publications

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“…In the same study, the authors observed that astemizole clearly prevented HCC development in vivo . Another recent finding [ 168 ] reported that several potassium channels were overexpressed in the liver only in the presence of the chemical carcinogen diethylnitrosamine; when the carcinogen treatment finished, the channel mRNA levels returned almost to normal values. The authors suggested that some potassium channels may serve as carcinogen exposure indicators and that gene expression of the Abcc3 transporter may serve as a liver tumor marker.…”

Section: Cancermentioning

confidence: 99%

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Ramírez

Vázquez-Sánchez

Carrión-Robalino

et al. 2016

Oxidative Medicine and Cellular Longevity

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Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases. This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer. The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases.

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Section: Cancermentioning

confidence: 99%

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Ramírez

Vázquez-Sánchez

Carrión-Robalino

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…The importance of CACNA1H in cancer proliferation has been reported in several recent studies across a variety of cancer types [46], including breast carcinoma, retinoblastoma, neuroblastoma, glioma melanoma, and HCC [46,47]. However, this effect does not appear to depend on changes in CACNA1H expression during HCC development [48].…”

Section: Discussionmentioning

confidence: 99%

Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx

et al. 2019

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Background Administration of amplitude modulated 27·12 MHz radiofrequency electromagnetic fields (AM RF EMF) by means of a spoon-shaped applicator placed on the patient's tongue is a newly approved treatment for advanced hepatocellular carcinoma (HCC). The mechanism of action of tumour-specific AM RF EMF is largely unknown. Methods Whole body and organ-specific human dosimetry analyses were performed. Mice carrying human HCC xenografts were exposed to AM RF EMF using a small animal AM RF EMF exposure system replicating human dosimetry and exposure time. We performed histological analysis of tumours following exposure to AM RF EMF. Using an agnostic genomic approach, we characterized the mechanism of action of AM RF EMF. Findings Intrabuccal administration results in systemic delivery of athermal AM RF EMF from head to toe at levels lower than those generated by cell phones held close to the body. Tumour shrinkage results from differentiation of HCC cells into quiescent cells with spindle morphology. AM RF EMF targeted antiproliferative effects and cancer stem cell inhibiting effects are mediated by Ca 2+ influx through Ca v 3·2 T-type voltage-gated calcium channels (CACNA1H) resulting in increased intracellular calcium concentration within HCC cells only. Interpretation Intrabuccally-administered AM RF EMF is a systemic therapy that selectively block the growth of HCC cells. AM RF EMF pronounced inhibitory effects on cancer stem cells may explain the exceptionally long responses observed in several patients with advanced HCC. Fund Research reported in this publication was supported by the National Cancer Institute's Cancer Centre Support Grant award number P30CA012197 issued to the Wake Forest Baptist Comprehensive Cancer Centre (BP) and by funds from the Charles L. Spurr Professorship Fund (BP). DWG is supported by R01 AA016852 and P50 AA026117.

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“…61 Investigators found that 12 transporters (ABCA2, ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCC10, ABCC11, ABCC12, and ABCE1) were upregulated in HCC compared with healthy liver tissue. 61 Although several studies have demonstrated elevated ABCC3/Abcc3 mRNA expression in HCC liver nodules and tumors, [61][62][63] recently a role of ABCC3 in cancer initiation, promotion, and progression has been proposed. 62 In summary, differences in transporter expression in HCC tissues versus healthy liver tissue have been demonstrated.…”

Section: Hepatic Transporters In Disease Statesmentioning

confidence: 99%

Effect of Disease Pathologies on Transporter Expression and Function

Atilano-Roque

Roda

Fogueri

et al. 2016

The Journal of Clinical Pharma

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Transporters are important determinants of drug absorption, distribution, and excretion. The clinical relevance of drug transporters in drug disposition and toxicology depends on their localization in liver, kidney, and brain. There has been growing evidence regarding the importance of disease status on alterations in metabolizing enzymes and transporter proteins. This review focuses on uptake and efflux transporter proteins in liver, kidney, and brain and discusses mechanisms of altered transporter expression and function secondary to disease.

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Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development

Abstract: The ion channel/transporter expression profile observed suggests that these genes are potential early markers or therapeutic targets of HCC. The differential localization of Abcc3 may be useful in the diagnosis of cirrhosis and HCC.

Cited by 29 publications

References 43 publications

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx

Effect of Disease Pathologies on Transporter Expression and Function

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Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development

Abstract: The ion channel/transporter expression profile observed suggests that these genes are potential early markers or therapeutic targets of HCC. The differential localization of Abcc3 may be useful in the diagnosis of cirrhosis and HCC.

Cited by 29 publications

References 43 publications

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx

Effect of Disease Pathologies on Transporter Expression and Function

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Product

Resources

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Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx