Differential expression of Immunoglobulin A in the adenoids of children with and without exudative otitis media

Wang, Bing; Tang, Xinyi; Xu, Jie; Yao, Hongbing

doi:10.1016/j.ijporl.2012.02.036

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…Moreover, this examination is possible in most cases if performed by a skilled otorhinolaryngologist and preceded by careful explanation to the child. Finally, the possibility of direct visualization of the image via a monitor allows the clinical situation to be explained better to the child's parents (Wang et al, ). The authors later confirmed their 1997 results on a larger cohort of 817 children (Wang et al, ).…”

Section: Diagnosismentioning

confidence: 99%

“…Secretory IgA is the main antibody class in adenoidal tissue and is important in mucosal immunity, binding to bacteria and suppressing bacterial colonization of the epithelium. Some authors have recently pointed out that IgA expression is significantly lower than normal in the adenoids of children suffering from otitis media (OM) with effusion (Wang et al, ). Moreover, under normal conditions, the active interaction between innate and adaptive immunity, and with nonspecific mechanical factors (such ciliary movement), potentially contribute to preventing microorganism invasion.…”

Section: Histology and Immunologymentioning

confidence: 99%

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Adenoids in children: Advances in immunology, diagnosis, and surgery

et al. 2014

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Adenoids are strategically located for mediating local and regional immune functions as they are exposed to antigens from both the outside air and the alimentary tract. Recurrent or chronic respiratory infections can induce histomorphological and functional changes in the adenoidal immunological barrier, sometimes making surgical treatment necessary. Our aim in this review is to summarize the crucial points about not only the immunological histopathology of adenoidal tissue, especially in patients with adenoid hypertrophy, but also the most common and useful diagnostic techniques and surgical options.

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Section: Diagnosismentioning

confidence: 99%

Section: Histology and Immunologymentioning

confidence: 99%

Adenoids in children: Advances in immunology, diagnosis, and surgery

et al. 2014

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“…However, its production is very low in the first years of life, reaching normalization no earlier than 10 years [33]. In children older than four years with problems of tubal obstruction, it was observed that they had lower levels of IgA than normal children [34]. It seems that the presence of biofilms on the adenoid surface could be a reservoir of microorganisms that could cause chronic inflammation [35].…”

Section: Discussionmentioning

confidence: 99%

Persistent Nasal Obstruction: An Expression of the Pro-Inflammatory State?

Calatayud-Sáez¹,

Calatayud²,

Calatayud³

2021

Sinusitis

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Introduction: During the first years of life, the oro-pharyngeal lymphoid tissue gradually increases in size, causing in some children difficulty breathing and often leading to surgical removal of the tonsils and adenoids. The objective of the study is to assess the effects of the Mediterranean diet in children who had chronic upper airway obstruction. Material and methods: This was a prospective study pre-test/post-test comparison. Eighty-seven patients from two to eight years old were recruited. A food reeducation program based on the Mediterranean diet was applied for one year. Clinical, therapeutic, and anthropometric variables were studied. Results: The degree of nasal obstruction decreased in 95.1% of the patients. After the nutritional intervention, the number of colds with bacterial complications decreased by 80.26%; 60.9% had no bacterial complications during the year of the study. The use of antibiotics decreased by 81.94%. Symptomatic treatment decreased by 61.2%. Most patients did not require surgical intervention, and clinical evolution suggested that it would no longer be necessary. Conclusions: We can conclude by saying that the application of the traditional Mediterranean diet could be effective in the prevention and treatment of persistent nasal obstruction, limiting pharmacological and surgical intervention in many of these patients.

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“…Third, SIgA may block some antigens, preventing an increased antigen uptake in the nasal epithelium and subsequent allergic reaction. [22] Therefore, IgA is an important immune factor in adenoids and tonsils. Our results again demonstrated the importance of IgA in the immune function of adenoids and tonsils, which may be the reason why adenoidectomy with/without tonsillectomy resulted in a short-term decrease in serum IgA level.…”

Section: Discussionmentioning

confidence: 99%

Short- and long-term impacts of adenoidectomy with/without tonsillectomy on immune function of young children <3 years of age

Yan¹,

Song²,

Liu³

et al. 2019

Medicine

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To investigate the short- and long-term impacts of adenoidectomy with/without tonsillectomy on the immune functions of young children < 3 years of age. This longitudinal prospective study included 40 pediatric patients (age <3 y) undergoing adenoidectomy with/without tonsillectomy for snoring and sleep apnea. Serum immunoglobulin IgA, IgG, IgM, complement C3, and C4 levels were measured for the status of humoral immunity; CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cells were measured for the status of cellular immunity. Blood samples were taken at 3 time points: before surgery, 1 month after surgery (short-term), and 3 months after surgery (long-term). All patients were assessed for short-term outcome at 1-month postoperation, but only 30 patients were followed at 3 months after surgery. The incidence of recurrent respiratory tract infections and other immune-related conditions were recorded at each follow-up. The levels of IgA significantly decreased from the preoperative level at 1-month follow-up ( P < .05), but still within normal range. No significant changes were found in the levels of IgA, IgG, IgM, C3, C4, CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cell at 3-month follow-up in comparison with preoperative levels. There was also no episode of recurrent respiratory tract infection and other immune-deficiency conditions. Adenoidectomy with/without tonsillectomy may result in a reduction in individual antibodies in children <3 years of age, but did not show negative impacts on their immune functions. Also, the surgery does not lead to the increased risk of upper respiratory tract infection in these children.

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Differential expression of Immunoglobulin A in the adenoids of children with and without exudative otitis media

Cited by 5 publications

References 15 publications

Adenoids in children: Advances in immunology, diagnosis, and surgery

Adenoids in children: Advances in immunology, diagnosis, and surgery

Persistent Nasal Obstruction: An Expression of the Pro-Inflammatory State?

Short- and long-term impacts of adenoidectomy with/without tonsillectomy on immune function of young children <3 years of age

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